Protein Flexibility: A Challenging Issue of Drug Discovery

Background: Now-a-days, drug design is an important area of research in medicinal chemistry and theoretical aspects of it basically involve molecular docking. Therefore, a detailed knowledge of drug targets, de facto of proteins/enzymes, is essential and thus it has created interest in the study of protein structure and its flexible nature. Objective: The article aims to describe in detail the flexible nature of proteins and its implication in

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