High-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry

Recent developments in NMR spectroscopy have created two complementary categories of analysis for drug discovery processes. The first category includes techniques for obtaining high-resolution (especially 1H) NMR spectra of compounds still bound to solid-phase synthesis resins. The second category includes an automated high-throughput spectroscopy technique for acquiring high-resolution NMR spectra of liquids, directly sampled from microtiter plates, in a ‘tubeless’ mode, without the use of expensive deuterated solvents. This review summarizes these recent developments.

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