Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study

Musculoskeletal diseases, especially osteoarthritis (OA) and osteoporosis (OP), impair activities of daily life (ADL) and quality of life (QOL) in the elderly. Although preventive strategies for these diseases are urgently required in an aging society, epidemiological data on these diseases are scant. To clarify the prevalence of knee osteoarthritis (KOA), lumbar spondylosis (LS), and osteoporosis (OP) in Japan, and estimate the number of people with these diseases, we started a large-scale population-based cohort study entitled research on osteoarthritis/osteoporosis against disability (ROAD) in 2005. This study involved the collection of clinical information from three cohorts composed of participants located in urban, mountainous, and coastal areas. KOA and LS were radiographically defined as a grade of ≥2 by the Kellgren–Lawrence scale; OP was defined by the criteria of the Japanese Society for Bone and Mineral Research. The 3,040 participants in total were divided into six groups based on their age: ≤39, 40–49, 50–59, 60–69, 70–79, and ≥80 years. The prevalence of KOA in the age groups ≤39, 40–49, 50–59, 60–69, 70–79, and ≥80 years 0, 9.1, 24.3, 35.2, 48.2, and 51.6%, respectively, in men, and the prevalence in women of the same age groups was 3.2, 11.4, 30.3, 57.1, 71.9, and 80.7%, respectively. With respect to the age groups, the prevalence of LS was 14.3, 45.5, 72.9, 74.6, 85.3, and 90.1% in men, and 9.7, 28.6, 41.7, 55.4, 75.1, and 78.2% in women, respectively. Data of the prevalence of OP at the lumbar spine and femoral neck were also obtained. The estimated number of patients with KOA, LS, and L2–L4 and femoral neck OP in Japan was approximately 25, 38, 6.4, and 11 million, respectively. In summary, we estimated the prevalence of OA and OP, and the number of people affected with these diseases in Japan. The ROAD study will elucidate epidemiological evidence concerning determinants of bone and joint disease.

[1]  Hajime Orimo,et al.  Diagnostic criteria for primary osteoporosis: year 2000 revision , 2001, Journal of Bone and Mineral Metabolism.

[2]  M. Fukunaga,et al.  Fracture Prediction From Bone Mineral Density in Japanese Men and Women , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  J. Kellgren,et al.  Radiological Assessment of Osteo-Arthrosis , 1957, Annals of the rheumatic diseases.

[4]  F. Schmidt.  Meta-Analysis , 2008 .

[5]  N. Watts,et al.  New Guidelines for the Prevention and Treatment of Osteoporosis , 2009, Southern medical journal.

[6]  Y. Yoshida,et al.  Association Between Change in Bone Mineral Density and Decline in Usual Walking Speed in Elderly Community‐Dwelling Japanese Women During 2 Years of Follow‐Up , 2007, Journal of the American Geriatrics Society.

[7]  S. Lord,et al.  Predictors of Cessation of Regular Leisure-Time Physical Activity in Community-Dwelling Elderly People , 2007, Gerontology.

[8]  M. Iki,et al.  Low bone mass is associated with carotid atherosclerosis in postmenopausal women: The Japanese Population-based Osteoporosis (JPOS) Cohort Study , 2008, Osteoporosis International.

[9]  T. Spector,et al.  The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. , 1993, The Journal of rheumatology.

[10]  Kozo Nakamura,et al.  Factors associated with mortality following hip fracture in Japan , 2005, Journal of Bone and Mineral Metabolism.

[11]  T. Kasamatsu,et al.  Bone Loss at the Lumbar Spine and the Proximal Femur in a Rural Japanese Community, 1990–2000: The Miyama Study , 2002, Osteoporosis International.

[12]  Y. Koga,et al.  [Osteoarthritis of the knee joint: a field study]. , 1994, Nihon Seikeigeka Gakkai zasshi.

[13]  L. Kazis,et al.  The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. , 1987, Arthritis and rheumatism.

[14]  David T Felson,et al.  Comparison of the prevalence of radiographic osteoarthritis of the knee and hand between Japan and the United States. , 2002, The Journal of rheumatology.

[15]  Toshitaka Nakamura.  [Japanese Guidelines for the Prevention and Treatment of Osteoporosis (2006 Edition) and its significance]. , 2007, Nihon rinsho. Japanese journal of clinical medicine.

[16]  C. Cooper,et al.  Epidemiology of chronic disc degeneration and osteoarthritis of the lumbar spine in Britain and Japan: a comparative study. , 2000, The Journal of rheumatology.

[17]  C. Cooper,et al.  Acetabular dysplasia and hip osteoarthritis in Britain and Japan. , 1998, British journal of rheumatology.

[18]  C. Cooper,et al.  Determinants of Bone Loss in a Rural Japanese Community: The Taiji Study , 1998, Osteoporosis International.

[19]  O. Johnell,et al.  Mortality after osteoporotic fractures , 2004, Osteoporosis International.

[20]  H. Oka,et al.  Prevalence of radiographic lumbar spondylosis and its association with low back pain in elderly subjects of population-based cohorts: the ROAD study , 2008, Annals of the rheumatic diseases.

[21]  H. Kroger,et al.  Body mass index as a predictor of fracture risk: A meta-analysis , 2005, Osteoporosis International.