TMEM59 protects against cerebral ischemic stroke by suppressing pyroptosis and microglial activation.

[1]  J. Ai,et al.  MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling , 2020, Journal of Neuroinflammation.

[2]  M. Lamkanfi,et al.  Therapeutic modulation of inflammasome pathways , 2020, Immunological reviews.

[3]  Huaxi Xu,et al.  TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities , 2020, Cell Death & Disease.

[4]  Guo-Yuan Yang,et al.  Farnesoid X receptor knockout protects brain against ischemic injury through reducing neuronal apoptosis in mice , 2020, Journal of Neuroinflammation.

[5]  C. Iadecola,et al.  Immune responses to stroke: mechanisms, modulation, and therapeutic potential. , 2020, The Journal of clinical investigation.

[6]  J. Schulz,et al.  Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke , 2020, Journal of Molecular Medicine.

[7]  Jia Hu,et al.  NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy , 2020, Redox biology.

[8]  L. McCullough,et al.  Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes , 2019, Proceedings of the National Academy of Sciences.

[9]  D. Choubey Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease , 2019, Journal of Neuroinflammation.

[10]  Yu-hong Yuan,et al.  NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling , 2019, Cell Death & Disease.

[11]  Si Ming Man,et al.  Emerging Activators and Regulators of Inflammasomes and Pyroptosis. , 2019, Trends in immunology.

[12]  W. Guo,et al.  Pterostilbene Attenuates Astrocytic Inflammation and Neuronal Oxidative Injury After Ischemia-Reperfusion by Inhibiting NF-κB Phosphorylation , 2019, Front. Immunol..

[13]  J. Xie,et al.  Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis. , 2019, Life sciences.

[14]  Haiying Li,et al.  Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro , 2019, Journal of neuroscience research.

[15]  Y. Guan,et al.  Tmem59 deletion activates microglia and reduces phagocytic capacity , 2019 .

[16]  Zhe Zhang,et al.  Valproic acid attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-pyroptosis pathways , 2019, Neurochemistry International.

[17]  D. Haussen,et al.  Current Understanding and Gaps in Research of Carotid Webs in Ischemic Strokes: A Review , 2019, JAMA neurology.

[18]  K. Lambertsen,et al.  Post-stroke inflammation—target or tool for therapy? , 2018, Acta Neuropathologica.

[19]  Zhenhua Zhou,et al.  Advances in stroke pharmacology , 2018, Pharmacology & therapeutics.

[20]  D. Egan,et al.  TMEM59 potentiates Wnt signaling by promoting signalosome formation , 2018, Proceedings of the National Academy of Sciences.

[21]  Q. Guo,et al.  Pioglitazone Confers Neuroprotection Against Ischemia-Induced Pyroptosis due to its Inhibitory Effects on HMGB-1/RAGE and Rac1/ROS Pathway by Activating PPAR-ɤ , 2018, Cellular Physiology and Biochemistry.

[22]  Cheng He,et al.  Establishment and characterization of primary astrocyte culture from adult mouse brain , 2017, Brain Research Bulletin.

[23]  Wenqing Gao,et al.  Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. , 2017, Trends in biochemical sciences.

[24]  Pei Wang,et al.  The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia. , 2017, Metabolism: clinical and experimental.

[25]  Haifeng Wang,et al.  MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis , 2012, RNA biology.

[26]  Xiuyun Guo,et al.  Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles , 2011, BMC Systems Biology.

[27]  A. Betz,et al.  Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. , 1992, Neurosurgery.

[28]  W-Y Zhang,et al.  Effects of propofol on myocardial ischemia reperfusion injury through inhibiting the JAK/STAT pathway. , 2019, European review for medical and pharmacological sciences.

[29]  Celvie L Yuan,et al.  A Transgenic Core Facility's Experience in Genome Editing Revolution. , 2017, Advances in experimental medicine and biology.

[30]  J. Lieberman,et al.  A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection. , 2017, Advances in immunology.

[31]  Howard Hu,et al.  Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex. , 2012, Journal of Alzheimer's disease : JAD.