Preparation and Properties of a Chitosan–Hyaluronic Acid-Polypyrrole Conductive Hydrogel Catalyzed by Laccase

Electro conductive hydrogels, consisting of chitosan (CS), hyaluronic acid (HA), and polypyrrole (PPy), were prepared via an in situ enzymic polymerization of pyrrole in the CS–HA hydrogel, using laccase as the catalyst. This CS–HA–PPy composite hydrogel showed good conductivity. The chemical structure and morphology of this conductive hydrogel were studied by Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction technique. For CS–HA–PPy and CH–HA hydrogel, the temperature at which fastest decomposition occurred was 260 and 244 °C, respectively. That means the thermal stability of CS–HA–PPy is better than CS–HA hydrogel. The conductive hydrogel also showed excellent swelling and deswelling behaviors.

[1]  Lijia Pan,et al.  Rational design and applications of conducting polymer hydrogels as electrochemical biosensors. , 2015, Journal of materials chemistry. B.

[2]  Ruixia Chen,et al.  In situ formation of chitosan-gold hybrid hydrogel and its application for drug delivery. , 2012, Colloids and surfaces. B, Biointerfaces.

[3]  Meifang Zhu,et al.  Swelling behavior of thermosensitive nanocomposite hydrogels composed of oligo(ethylene glycol) methacrylates and clay , 2015 .

[4]  M. Tian,et al.  Preparation and characterization of sulfonated graphene-enhanced poly (vinyl alcohol) composite hydrogel and its application as dye absorbent , 2015 .

[5]  Yanmin Zhao,et al.  Preparation and Characterization of Hyaluronic Acid Hydrogel Blends with Gelatin , 2012 .

[6]  B. Saikia,et al.  Electrical actuation of electroresponsive hydrogels based on poly(acrylamide‐co‐acrylic acid)/graphite suitable for biomedical applications , 2014 .

[7]  A. Dilmi,et al.  Hydrogels Based on 2-Hydroxyethylmethacrylate and Chitosan: Preparation, Swelling Behavior, and Drug Delivery , 2014 .

[8]  S. Maiti,et al.  Smart reticulated hydrogel of functionally decorated gellan copolymer for prolonged delivery of salbutamol sulphate to the gastro-luminal milieu , 2012, Journal of microencapsulation.

[9]  Wei Wei,et al.  Polypyrrole-coated cotton fabrics for flexible supercapacitor electrodes prepared using CuO nanoparticles as template , 2015, Cellulose.

[10]  Yiguang Jin,et al.  Wound Healing Effect of an in Situ Forming Hydrogel Loading Curcumin-Phospholipid Complex. , 2016, Current drug delivery.

[11]  V. Dubey,et al.  Glutaraldehyde-activated chitosan matrix for immobilization of a novel cysteine protease, procerain B. , 2011, Journal of agricultural and food chemistry.

[12]  I. Willner,et al.  Hemin–G-quadruplex-crosslinked poly-N-isopropylacrylamide hydrogel: a catalytic matrix for the deposition of conductive polyaniline† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc02203g , 2015, Chemical science.

[13]  Y. Kuo,et al.  pH-Sensitive Hollow Alginate-Chitosan Hydrogel Beads for Bitter Gourd Delivery , 2014 .

[14]  F. Ganji,et al.  Thermosensitive hydrogel for periodontal application: in vitro drug release, antibacterial activity and toxicity evaluation , 2016, Journal of biomaterials applications.

[15]  Jin Suk Chung,et al.  Synthesis of a highly conductive and large surface area graphene oxide hydrogel and its use in a supercapacitor , 2013 .

[16]  Lukas D. Schuler,et al.  Enzymatic polymerization of pyrrole with Trametes versicolor laccase and dioxygen in the presence of vesicles formed from AOT (sodium bis-(2-ethylhexyl) sulfosuccinate) as templates , 2015 .

[17]  Seung‐Woo Cho,et al.  Synthesis of electroconductive hydrogel films by an electro-controlled click reaction and their application to drug delivery systems , 2015 .

[18]  Yuhui Li,et al.  Engineering cell microenvironment using novel functional hydrogels , 2015 .

[19]  K. Anseth,et al.  Tissue Engineering: Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition (Adv. Healthcare Mater. 5/2015) , 2015 .

[20]  Geoffrey M. Spinks,et al.  Processable conducting graphene/chitosan hydrogels for tissue engineering. , 2015, Journal of materials chemistry. B.

[21]  Tian Jian Lu,et al.  Magnetic Hydrogels and Their Potential Biomedical Applications , 2013 .