Techniques for the automated optimization of HPLC separations

Abstract The availability of computer controlled HPLC instrumentation has enabled more systematic approaches to be taken to the optimization of chromatographic separations. Many of these approaches are suitable for automated applications.

[1]  J. Berridge Unattended optimisation of reversed-phase high-performance liquid chromatographic separations using the modified simplex algorithm , 1982 .

[2]  John A. Nelder,et al.  A Simplex Method for Function Minimization , 1965, Comput. J..

[3]  Bernard G. M. Vandeginste,et al.  Optimization of analytical information , 1982 .

[4]  W. Wegscheider,et al.  A chromatographic response function for automated optimization of separations , 1982 .

[5]  A. Drouen,et al.  An improved optimization procedure for the selection of mixed mobile phases in reversed phase liquid chromatography , 1982 .

[6]  P. Jandera,et al.  Gradient elution in liquid chromatography , 1981 .

[7]  H. Billiet,et al.  Use of gradient elution for rapid selection of isocratic conditions in reversed-phase high-performance liquid chormatography , 1981 .

[8]  G. R. Hext,et al.  Sequential Application of Simplex Designs in Optimisation and Evolutionary Operation , 1962 .

[9]  M. B. Denton,et al.  A Review of Simplex Optimization in Analytical Chemistry , 1978 .

[10]  P. Carr,et al.  Simplex algorithm for the optimization of gradient elution high-performance liquid chromatography , 1979 .

[11]  A. Drouen,et al.  A simple procedure for the rapid optimization of reversed-phase separations with ternary mobile phase mixtures , 1982 .

[12]  L. Snyder Classification off the Solvent Properties of Common Liquids , 1978 .

[13]  S. Deming,et al.  Optimization of reverse-phase liquid chromatographic separation of weak organic acids , 1978 .

[14]  James M. Minor,et al.  Optimization of solvent strength and selectivity for reversed-phase liquid chromatography using an interactive mixture-design statistical technique , 1980 .

[15]  Bruce R. Kowalski,et al.  Analytical chemistry as an information science , 1981 .

[16]  J. Berridge Unattended optimisation of normal phase high-performance liquid chromatography separations with a microcomputer controlled chromatograph , 1982 .