Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
暂无分享,去创建一个
Bjarni V. Halldórsson | D. Kiel | C. Gieger | U. Thorsteinsdóttir | K. Stefánsson | V. Salomaa | M. Perola | J. Hirschhorn | M. Laakso | M. Mangino | V. Gudnason | I. Borecki | F. Rivadeneira | C. Fox | G. Thorleifsson | P. Talmud | S. O’Rahilly | S. Ripatti | E. Ingelsson | B. Isomaa | E. Speliotes | C. Guiducci | N. Klopp | A. Syvänen | I. Rudan | R. Luben | J. Ried | A. Jula | V. Mooser | L. Cupples | N. Soranzo | Gunnar Sigurdsson | K. Estrada | D. Mellström | J. Kooner | I. Barroso | N. Amin | C. Hayward | G. Eiriksdottir | M. Garcia | P. Vollenweider | G. Waeber | M. Feitosa | J. Luan | A. Stančáková | J. Kuusisto | C. Langenberg | J. Chambers | C. Ohlsson | A. Shuldiner | N. Glazer | Y. Aulchenko | B. Mitchell | S. Vedantam | E. Tikkanen | S. Männistö | M. Kumari | T. Haritunians | C. Duijn | J. Fernández-Real | M. Zillikens | M. Lorentzon | B. McKnight | L. Vandenput | A. Arnold | J. Jansson | Mao Fu | A. Vidal-Puig | D. Savage | L. Jacobs | D. Karasik | Lauren J. Kim | Yanhua Zhou | Mark Walker | R. Semple | Ö. Ljunggren | L. Pascoe | H. Wichmann | T. Škarić‐Jurić | Steve E. Humphries | K. Khaw | Harry Campbell | James F. Wilson | U. Styrkársdóttir | A. Hofman | Kijoung Song | T. Spector | R. Kaplan | A. Smith | S. Shin | Weihua Zhang | A. Uitterlinden | J. R. O'Connell | B. Oostra | B. Psaty | Brigitte Kühnel | L. Peltonen | R. Loos | T. B. Harris | Tuomas O. Kilpeläinen | A. Wright | M. Kivimäki | Yongmei Liu | Leif Groop | Jing-Hua Zhao | Nicholas J. Wareham | Jacques S Beckmann | Eric Schadt | Angela Döring | Francis M Finucane | Ci Song | Kathryn E Davis | Angela Döring | Magnus K Karlsson | José Maria Moreno | Belén Peral | Sarah H. Wild | Deborah J Clegg | Jacques S. Beckmann
[1] Thomas Meitinger,et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution , 2010, Nature Genetics.
[2] T. Hansen,et al. Physiologic Characterization of Type 2 Diabetes–Related Loci , 2010, Current diabetes reports.
[3] L. Liaw,et al. Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[4] Tanya M. Teslovich,et al. Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.
[5] P. Scherer,et al. Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. , 2010, Endocrinology.
[6] Xia Yang,et al. Integrating pathway analysis and genetics of gene expression for genome-wide association studies. , 2010, American journal of human genetics.
[7] Raimund Erbel,et al. Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups , 2010, PLoS genetics.
[8] Jean Tichet,et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia , 2009, Nature Genetics.
[9] Alkes L. Price,et al. Reconstructing Indian Population History , 2009, Nature.
[10] M. Stumvoll,et al. Multiple sites of insulin resistance: muscle, liver and adipose tissue. , 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
[11] Suzette J. Bielinski,et al. NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium , 2009, PLoS genetics.
[12] Laura J. Scott,et al. Edinburgh Research Explorer Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution , 2022 .
[13] Barbara Heude,et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations , 2009, Nature Genetics.
[14] A. Vidal-Puig,et al. It's Not How Fat You Are, It's What You Do with It That Counts , 2008, PLoS biology.
[15] Subhajyoti De,et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity , 2008, Nature Genetics.
[16] Philippe Froguel,et al. Common genetic variation near MC4R is associated with waist circumference and insulin resistance , 2008, Nature Genetics.
[17] H. Stefánsson,et al. Genetics of gene expression and its effect on disease , 2008, Nature.
[18] G. Christofori,et al. Sprouty proteins, masterminds of receptor tyrosine kinase signaling , 2008, Angiogenesis.
[19] D. Stephan,et al. A survey of genetic human cortical gene expression , 2007, Nature Genetics.
[20] G. Shulman,et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. , 2007, The Journal of clinical investigation.
[21] Manuel A. R. Ferreira,et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.
[22] C. Gieger,et al. Genomewide association analysis of coronary artery disease. , 2007, The New England journal of medicine.
[23] P. Donnelly,et al. A new multipoint method for genome-wide association studies by imputation of genotypes , 2007, Nature Genetics.
[24] James Strait,et al. Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits , 2007, PLoS genetics.
[25] M. Stephens,et al. Imputation-Based Analysis of Association Studies: Candidate Regions and Quantitative Traits , 2007, PLoS genetics.
[26] M. Jarvelin,et al. A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity , 2007, Science.
[27] J. Flier,et al. The adipocyte as an active participant in energy balance and metabolism. , 2007, Gastroenterology.
[28] S Kumar,et al. Type 2 diabetes and cardiovascular risk in the UK south Asian community , 2006, Diabetologia.
[29] Chunxiang Zhang,et al. Regulation of Vascular Smooth Muscle Cell Proliferation and Migration by Human Sprouty 2 , 2005, Arteriosclerosis, thrombosis, and vascular biology.
[30] G. Woude,et al. Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis , 2004, Oncogene.
[31] C. Kahn,et al. Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation , 2004, Molecular and Cellular Biology.
[32] C. Kahn,et al. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. , 2002, Genes & development.
[33] P. Arner. Insulin resistance in type 2 diabetes: role of fatty acids , 2002, Diabetes/metabolism research and reviews.
[34] T. Patel,et al. The C Terminus of Sprouty Is Important for Modulation of Cellular Migration and Proliferation* , 2001, The Journal of Biological Chemistry.
[35] Y. Terauchi,et al. Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation , 2001, Molecular and Cellular Biology.
[36] A. Astrup,et al. Obesity : Preventing and managing the global epidemic , 2000 .
[37] B. Wajchenberg. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. , 2000, Endocrine reviews.
[38] N. Schneiderman,et al. Validation of the insulin sensitivity index (ISI(0,120)): comparison with other measures. , 2000, Diabetes research and clinical practice.
[39] M. Matsuda,et al. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. , 1999, Diabetes care.
[40] M. Quon,et al. Insulin Receptor Substrate-2 (IRS-2) Can Mediate the Action of Insulin to Stimulate Translocation of GLUT4 to the Cell Surface in Rat Adipose Cells* , 1997, The Journal of Biological Chemistry.
[41] Y. Yazaki,et al. Role of Insulin Receptor Substrate-1 and pp60 in the Regulation of Insulin-induced Glucose Transport and GLUT4 Translocation in Primary Adipocytes* , 1997, The Journal of Biological Chemistry.
[42] C. Kahn,et al. The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells. , 1997, Biochemistry.
[43] M. Neale,et al. Genetic and Environmental Factors in Relative Body Weight and Human Adiposity , 1997, Behavior genetics.
[44] C. Kahn,et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.
[45] T. Yagi,et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 , 1994, Nature.
[46] Tanya M. Teslovich,et al. LocusZoom: regional visualization of genome-wide association scan results , 2010, Bioinform..
[47] Tanya M. Teslovich,et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index , 2010 .
[48] Christian Gieger,et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation , 2009, Nature Genetics.
[49] Ellen Kampman,et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity , 2009, Nature Genetics.
[50] G. Abecasis,et al. Merlin—rapid analysis of dense genetic maps using sparse gene flow trees , 2002, Nature Genetics.
[51] Who Consultation on Obesity. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. , 2000, World Health Organization technical report series.