Potential role of the alcohol and smoking in the squamous cell carcinoma of the head and neck: review of the current literature and new perspectives.

Alcohol and tobacco are responsible for a very large proportion of chronic disease and some tumors in particular may be the result of interactions between the two risk factors. The present systematic literature review was conducted to judge combined effects of alcohol drinking and tobacco, as well as and genetic polymorphisms on alcohol-related cancer risk. We can conclude that the interaction of smoking and alcohol significantly increases the risk for aero-digestive cancers. Unfortunately, little is known about mechanisms and details of interaction with regard to disease outcomes, which is why particular questions must be targeted in future research efforts.

[1]  A. Olshan,et al.  Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. , 2004, American journal of epidemiology.

[2]  C. Pomerleau,et al.  Nicotine dependence and withdrawal in alcoholic and nonalcoholic ever-smokers. , 1997, Journal of substance abuse treatment.

[3]  S. Petti.  Lifestyle risk factors for oral cancer. , 2009, Oral oncology.

[4]  Ellen A Eisen,et al.  The ADH1C Polymorphism Modifies the Risk of Squamous Cell Carcinoma of the Head and Neck Associated with Alcohol and Tobacco Use , 2005, Cancer Epidemiology Biomarkers & Prevention.

[5]  S. Sanjosé,et al.  Human papillomavirus in cervical cancer , 2002, Current oncology reports.

[6]  D. Winn,et al.  Smoking and drinking in relation to oral and pharyngeal cancer. , 1988, Cancer research.

[7]  C. J. Chen,et al.  Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma. , 1995, Gastroenterology.

[8]  H. Jörnvall,et al.  The gamma 1 and gamma 2 subunits of human liver alcohol dehydrogenase. cDNA structures, two amino acid replacements, and compatibility with changes in the enzymatic properties. , 1986, European journal of biochemistry.

[9]  L. Pignataro,et al.  Association between methylenetetrahydrofolate reductase polymorphisms, alcohol intake and oropharyngolaryngeal carcinoma in northern Italy , 2005, The Journal of Laryngology & Otology.

[10]  G. Berglund,et al.  Antibodies against 5-hydroxymethyl-2'-deoxyuridine are associated with lifestyle factors and GSTM1 genotype: a report from the Malmö Diet and Cancer cohort. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[11]  P. Dayer,et al.  Role of alcohol dehydrogenase 3 and cytochrome P‐4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract , 2000, International journal of cancer.

[12]  S. Warnakulasuriya.  Global epidemiology of oral and oropharyngeal cancer. , 2009, Oral oncology.

[13]  T. Omori,et al.  Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. , 2002, Carcinogenesis.

[14]  J. Eluf-Neto,et al.  Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer , 2006, Head & neck.

[15]  C. Lieber,et al.  Cytochrome P-4502E1: its physiological and pathological role. , 1997, Physiological reviews.

[16]  J. Tsoh,et al.  Changes in smoking status among substance abusers: baseline characteristics and abstinence from alcohol and drugs at 12-month follow-up. , 2003, Drug and alcohol dependence.

[17]  W. Willett,et al.  Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. , 1997, Cancer research.

[18]  K. Matsuo,et al.  Gene–gene and gene–environment interactions between alcohol drinking habit and polymorphisms in alcohol‐metabolizing enzyme genes and the risk of head and neck cancer in Japan , 2007 .

[19]  C. Hill.  Alcool et risque de cancer , 2003 .

[20]  P. Schnurr,et al.  A prospective study of the effects of cigarette smoking and alcohol abuse on mortality , 1991, Journal of General Internal Medicine.

[21]  K. Straif,et al.  Carcinogenicity of alcoholic beverages. , 2007, The Lancet. Oncology.

[22]  C. Fisher,et al.  Tumour thickness predicts cervical nodal metastases and survival in early oral tongue cancer. , 2003, Oral oncology.

[23]  Jia Cao,et al.  CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking. , 2007, World journal of gastroenterology.

[24]  D. Locker,et al.  The role of diagnostic delays in the prognosis of oral cancer: a review of the literature. , 1998, Oral oncology.

[25]  S. Hercberg,et al.  Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer. , 2009, The Lancet. Oncology.

[26]  S. Kono,et al.  Methylenetetrahydrofolate reductase polymorphism, alcohol intake, and risks of colon and rectal cancers in Korea. , 2004, Cancer letters.

[27]  Shu-Juan Yang,et al.  Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China. , 2007, World journal of gastroenterology.

[28]  K. Matsuo,et al.  One‐carbon metabolism‐related gene polymorphisms and risk of head and neck squamous cell carcinoma: Case–control study , 2007, Cancer science.

[29]  D. Bandyopadhyay,et al.  Differential induction of CYP1A1 and CYP1B1 by benzo[a]pyrene in oral squamous cell carcinoma cell lines and by tobacco smoking in oral mucosa. , 2009, Oral oncology.

[30]  N. Al-Rajhi,et al.  Early stage carcinoma of oral tongue: prognostic factors for local control and survival. , 2000, Oral oncology.

[31]  P. Brennan,et al.  Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men , 2003, International journal of cancer.

[32]  Tianxia Wu,et al.  Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer risk , 2002, International journal of cancer.

[33]  M. Spitz,et al.  Second primary tumors in patients with upper aerodigestive tract cancers: joint effects of smoking and alcohol (United States) , 2003, Cancer Causes & Control.

[34]  C. la Vecchia,et al.  Trends in oral cancer mortality in Europe. , 2004, Oral oncology.

[35]  Ting-kai Li,et al.  Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism , 1986, Hepatology.

[36]  P. Brennan,et al.  Evidence for an Important Role of Alcohol- and Aldehyde-Metabolizing Genes in Cancers of the Upper Aerodigestive Tract , 2006, Cancer Epidemiology Biomarkers & Prevention.

[37]  H. Becher,et al.  Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1. , 2003, Pharmacogenetics.

[38]  J. Webster-Cyriaque,et al.  Oropharyngeal carcinoma in non-smokers and non-drinkers: a role for HPV. , 2009, Oral oncology.

[39]  Jang-Ming Lee,et al.  Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks , 2006, International journal of cancer.

[40]  M. Latorre,et al.  Perioperative complications, comorbidities, and survival in oral or oropharyngeal cancer. , 2003, Archives of otolaryngology--head & neck surgery.

[41]  B. Henderson,et al.  The MTHFR C677T Polymorphism and Colorectal Cancer: The Multiethnic Cohort Study , 2005, Cancer Epidemiology Biomarkers & Prevention.

[42]  T. Burling,et al.  Tobacco smoking: a comparison between alcohol and drug abuse inpatients. , 1988, Addictive behaviors.

[43]  P. Brennan,et al.  Multiple ADH genes are associated with upper aerodigestive cancers , 2008, Nature Genetics.

[44]  S. Franceschi,et al.  Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. , 2003, Journal of the National Cancer Institute.

[45]  T Takezaki,et al.  Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. , 2001, Carcinogenesis.

[46]  W. Han,et al.  Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. , 2003, Pharmacogenetics.

[47]  Carole Fakhry,et al.  Case-control study of human papillomavirus and oropharyngeal cancer. , 2007, The New England journal of medicine.

[48]  M. Gold,et al.  Comorbid cigarette and alcohol addiction: epidemiology and treatment. , 1998, Journal of addictive diseases.

[49]  R. C. Chang,et al.  Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival. , 2003, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[50]  C. J. Chen,et al.  CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. , 1997, Journal of the National Cancer Institute.

[51]  T. Omori,et al.  Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma. , 2006, Carcinogenesis.

[52]  C. Wheeler,et al.  A controlled trial of a human papillomavirus type 16 vaccine. , 2002, The New England journal of medicine.

[53]  F. Stickel,et al.  “Allgemeine und systematische Pharmakologie und Toxikologie” WS 18/19 Seminarthema: Chemische Kanzerogenese , 2017 .

[54]  J. Aguirre,et al.  Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool? , 2007, Cancer letters.

[55]  F. Stickel,et al.  Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism , 2010, Genes & Nutrition.

[56]  M. Morita,et al.  Risk factors for esophageal cancer and the multiple occurrence of carcinoma in the upper aerodigestive tract. , 2002, Surgery.

[57]  H. Saeki,et al.  The relation of alcohol consumption and cigarette smoking to the multiple occurrence of esophageal dysplasia and squamous cell carcinoma. , 2002, Surgery.

[58]  D. Fahey.  Head and neck tumors. , 1955, A.M.A. archives of otolaryngology.

[59]  E. Rimm,et al.  A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. , 1996, Cancer research.

[60]  A. Zygogianni,et al.  Oral squamous cell cancer: early detection and the role of alcohol and smoking , 2011, Head & neck oncology.

[61]  E. Quertemont.  Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism , 2004, Molecular Psychiatry.

[62]  K. Matsuo,et al.  Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions. , 2005, Asian Pacific journal of cancer prevention : APJCP.

[63]  M. Spitz,et al.  Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never-smokers: a matched pair analysis. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[64]  I. Roots,et al.  Association of arylamine N-acetyltransferases NAT1 and NAT2 genotypes to laryngeal cancer risk. , 1999, Pharmacogenetics.

[65]  J. Yoon,et al.  Lack of association of cytochrome P450 2E1 genetic polymorphisms with the risk of human hepatocellular carcinoma , 1997, International journal of cancer.

[66]  M. Leppert,et al.  Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[67]  C. la Vecchia,et al.  Combined effect of tobacco and alcohol on laryngeal cancer risk: a case–control study , 2002, Cancer Causes & Control.

[68]  J. Pintos,et al.  Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada. , 2008, Oral oncology.

[69]  J. Difranza,et al.  Alcoholism and smoking. , 1990, Journal of studies on alcohol.

[70]  B. Lacarelle,et al.  Effects of tobacco smoke on the gene expression of the Cyp1a, Cyp2b, Cyp2e, and Cyp3a subfamilies in mouse liver and lung: relation to single strand breaks of DNA. , 1998, Toxicology and applied pharmacology.