Direct and indirect effects of particulate matter on the cardiovascular system.

Human exposure to particulate matter (PM) elicits a variety of responses on the cardiovascular system through both direct and indirect pathways. Indirect effects of PM on the cardiovascular system are mediated through the autonomic nervous system, which controls heart rate variability, and inflammatory responses, which augment acute cardiovascular events and atherosclerosis. Recent research demonstrates that PM also affects the cardiovascular system directly by entry into the systemic circulation. This process causes myocardial dysfunction through mechanisms of reactive oxygen species production, calcium ion interference, and vascular dysfunction. In this review, we will present key evidence in both the direct and indirect pathways, suggest clinical applications of the current literature, and recommend directions for future research.

[1]  A. D. Diez Roux,et al.  Associations between Recent Exposure to Ambient Fine Particulate Matter and Blood Pressure in the Multi-Ethnic Study of Atherosclerosis (MESA) , 2008, Environmental health perspectives.

[2]  F. Epstein,et al.  Abnormal intracellular modulation of calcium as a major cause of cardiac contractile dysfunction. , 1991, The New England journal of medicine.

[3]  A. Shimada,et al.  Translocation Pathway of the Intratracheally Instilled Ultrafine Particles from the Lung into the Blood Circulation in the Mouse , 2006, Toxicologic pathology.

[4]  W. MacNee,et al.  Particulate air pollution and acute health effects , 1995, The Lancet.

[5]  Lung-Chi Chen,et al.  Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats. , 1998, Toxicology letters.

[6]  T. Risby,et al.  Chemical characterization of organic adsorbates on diesel particulate matter , 1982 .

[7]  Seung-sik Hwang,et al.  Seasonal variation of effect of air pollution on blood pressure , 2007, Journal of Epidemiology and Community Health.

[8]  T. Sandström,et al.  Adverse cardiovascular effects of air pollution , 2009, Nature Clinical Practice Cardiovascular Medicine.

[9]  R. Kloner,et al.  In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias , 2007, Cardiovascular Toxicology.

[10]  S. Yusuf,et al.  Global burden of cardiovascular disease , 2007, Heart.

[11]  M. Sagai,et al.  The cytotoxic effects of diesel exhaust particles on human pulmonary artery endothelial cells in vitro: role of active oxygen species. , 2001, Free radical biology & medicine.

[12]  M F Hoylaerts,et al.  Ambient air pollution and acute myocardial infarction , 2005, Journal of thrombosis and haemostasis : JTH.

[13]  D. Sin,et al.  Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[14]  M F Hoylaerts,et al.  Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. , 2001, American journal of respiratory and critical care medicine.

[15]  G. Anderson,et al.  American Journal of Epidemiology Original Contribution Heart Rate Variability, Ambient Particulate Matter Air Pollution, and Glucose Homeostasis: the Environmental Epidemiology of Arrhythmogenesis in the Women's Health Initiative , 2022 .

[16]  K. Korach,et al.  The Short-Chain Fatty Acid Methoxyacetic Acid Disrupts Endogenous Estrogen Receptor-α–Mediated Signaling , 2009, Environmental health perspectives.

[17]  R. Devlin,et al.  Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. , 2000, American journal of respiratory and critical care medicine.

[18]  P. Bernardi,et al.  Mitochondrial transport of cations: channels, exchangers, and permeability transition. , 1999, Physiological reviews.

[19]  R. Kloner,et al.  Particulate air pollution and coronary heart disease , 2009, Current opinion in cardiology.

[20]  J. Weiss,et al.  Quinones and Aromatic Chemical Compounds in Particulate Matter Induce Mitochondrial Dysfunction: Implications for Ultrafine Particle Toxicity , 2004, Environmental health perspectives.

[21]  B. Coller.  Antiplatelet agents in the prevention and therapy of thrombosis. , 1992, Annual review of medicine.

[22]  A. Takeshita,et al.  Rho-Kinase Is an Important Therapeutic Target in Cardiovascular Medicine , 2005 .

[23]  D. Nowak,et al.  Heart rate variability, hemostatic and acute inflammatory blood parameters in healthy adults after short-term exposure to welding fume , 2007, International archives of occupational and environmental health.

[24]  A. Nel,et al.  Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress , 2009, Particle and Fibre Toxicology.

[25]  P. Borm,et al.  The Effect of Particulate Matter on Resistance and Conductance Vessels in the Rat , 2004, Inhalation toxicology.

[26]  Benoit Nemery,et al.  Diesel Exhaust Particles in Lung Acutely Enhance Experimental Peripheral Thrombosis , 2003, Circulation.

[27]  Terada,et al.  Diesel exhaust particulates upregulate histamine receptor mRNA and increase histamine‐induced IL‐8 and GM‐CSF production in nasal epithelial cells and endothelial cells , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[28]  V. Salomaa,et al.  Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis Study. , 2005, European heart journal.

[29]  D. Christiani,et al.  Time Course of Heart Rate Variability Decline Following Particulate Matter Exposures in an Occupational Cohort , 2008 .

[30]  J. Muller,et al.  Triggering of Acute Cardiovascular Disease and Potential Preventive Strategies , 2006, Circulation.

[31]  S. Rajagopalan,et al.  Ambient Air Particulate Matter Exposure and Tissue Factor Expression in Atherosclerosis , 2008 .

[32]  P. Ganz,et al.  Role of Endothelial Dysfunction in Atherosclerosis , 2004, Circulation.

[33]  M. Kampa,et al.  Human health effects of air pollution. , 2008, Environmental pollution.

[34]  Lianne Sheppard,et al.  Relation Between Short-Term Fine-Particulate Matter Exposure and Onset of Myocardial Infarction , 2005, Epidemiology.

[35]  D. Dockery,et al.  Increased Particulate Air Pollution and the Triggering of Myocardial Infarction , 2001, Circulation.

[36]  J. Schwartz,et al.  Heart rate variability associated with particulate air pollution. , 1999, American heart journal.

[37]  H. T. ter Keurs,et al.  Calcium and arrhythmogenesis. , 2007, Physiological reviews.

[38]  D. Costa,et al.  Cardiovascular and systemic responses to inhaled pollutants in rodents: effects of ozone and particulate matter. , 2001, Environmental health perspectives.

[39]  David E. Newby,et al.  Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis , 2005 .

[40]  H. Tsubone,et al.  Role of Reactive Oxygen Species on Diesel Exhaust Particle-Induced Cytotoxicity in Rat Cardiac Myocytes , 2006, Journal of toxicology and environmental health. Part A.

[41]  Annette Peters,et al.  Effects of air pollution on blood pressure: a population-based approach. , 2001, American journal of public health.

[42]  A. Iguchi,et al.  Endothelial-constitutive nitric oxide synthase exists in airways and diesel exhaust particles inhibit the effect of nitric oxide. , 1996, Life sciences.

[43]  Ronald W. Williams,et al.  Individual-level PM2.5 exposure and the time course of impaired heart rate variability: the APACR Study , 2011, Journal of Exposure Science and Environmental Epidemiology.

[44]  Qinghua Sun,et al.  Contemporary Reviews in Cardiovascular Medicine Cardiovascular Effects of Ambient Particulate Air Pollution Exposure , 2010 .

[45]  A. J. Williams,et al.  Modification of the gating of the cardiac sarcoplasmic reticulum Ca(2+)-release channel by H2O2 and dithiothreitol. , 1994, The American journal of physiology.

[46]  Joel Schwartz,et al.  Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter , 2009, Environmental health perspectives.

[47]  R. Burnett,et al.  Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease , 2003, Circulation.

[48]  M. Carr,et al.  Inflammation-induced plasticity of the afferent innervation of the airways. , 2001, Environmental health perspectives.

[49]  L. Mortelmans,et al.  Passage of Inhaled Particles Into the Blood Circulation in Humans , 2002, Circulation.

[50]  R. Brook,et al.  Air Pollution Exposure Potentiates Hypertension Through Reactive Oxygen Species–Mediated Activation of Rho/ROCK , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[51]  D. Leibfritz,et al.  Free radicals and antioxidants in normal physiological functions and human disease. , 2007, The international journal of biochemistry & cell biology.

[52]  Chris E Cooper,et al.  Exercise-Induced Oxidative Stress , 2005, Sports medicine.

[53]  G. Salama,et al.  Heavy metals induce rapid calcium release from sarcoplasmic reticulum vesicles isolated from skeletal muscle. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[54]  A Seaton,et al.  Ambient particle inhalation and the cardiovascular system: potential mechanisms. , 2001, Environmental health perspectives.

[55]  J. Hogg,et al.  Particulate air pollution induces progression of atherosclerosis. , 2002, Journal of the American College of Cardiology.

[56]  T. Sandström,et al.  Effects of particulate matter on the pulmonary and vascular system: time course in spontaneously hypertensive rats , 2005, Particle and Fibre Toxicology.

[57]  J. Hogg,et al.  Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10)). , 2001, American journal of respiratory and critical care medicine.

[58]  A. Peters,et al.  Particulate Matter Air Pollution and Cardiovascular Disease: An Update to the Scientific Statement From the American Heart Association , 2010, Circulation.

[59]  Hiroshi Ishii,et al.  Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment , 2005, Respiratory research.

[60]  F. Hofmann,et al.  Functional consequences of sulfhydryl modification in the pore-forming subunits of cardiovascular Ca2+ and Na+ channels. , 1995, Circulation research.

[61]  V. Fuster,et al.  Platelet-active drugs : the relationships among dose, effectiveness, and side effects. , 2004, Chest.

[62]  L. Wold,et al.  Particulate Matter Exposure Exacerbates High Glucose-Induced Cardiomyocyte Dysfunction through ROS Generation , 2011, PloS one.

[63]  Benoit Nemery,et al.  Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis. , 2003, Toxicology and applied pharmacology.

[64]  B. Nemery,et al.  Short‐term exposure to particulate matter induces arterial but not venous thrombosis in healthy mice , 2010, Journal of thrombosis and haemostasis : JTH.

[65]  R. Detrano,et al.  Fine Particulate Matter Air Pollution, Proximity to Traffic, and Aortic Atherosclerosis , 2009, Epidemiology.

[66]  Joel Schwartz,et al.  Chronic Fine and Coarse Particulate Exposure, Mortality, and Coronary Heart Disease in the Nurses’ Health Study , 2008, Environmental health perspectives.

[67]  W. Louch,et al.  Changes in excitation-contraction coupling in an isolated ventricular myocyte model of cardiac stunning. , 2002, American journal of physiology. Heart and circulatory physiology.

[68]  W. Coetzee,et al.  Oxidant stress inhibits Na-Ca-exchange current in cardiac myocytes: mediation by sulfhydryl groups? , 1994, The American journal of physiology.

[69]  S. Yusuf,et al.  Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies. , 2001, Circulation.

[70]  J. Schwartz,et al.  Exposure to particulate air pollution and risk of deep vein thrombosis. , 2008, Archives of internal medicine.

[71]  D. Warburton,et al.  Health benefits of physical activity: the evidence , 2006, Canadian Medical Association Journal.