Multi-channel EMG recording and muscle stimulation electrodes for diagnosis and treatment of tremor

This paper describes a new kind of multi-channel electrode for selectively interfacing the muscular system. Application of the system is similar to conventional intramuscular wire electrodes. A flexible polyimide thin-film structure is attached to a cannula which can be inserted into the muscle. The cannula can then be removed, so that only the polyimide electrode remains inside the muscle. Based on this concept, a 16-channel recording electrode as well as a 3-channel stimulation electrode were developed and tested in human volunteers. Fields of application for the system include the diagnosis and treatment of tremor patients by means of a neuroprosthetic platform.

[1]  K. Hoffmann,et al.  A measurement set-up to determine the charge injection capacity of neural microelectrodes , 2009 .

[2]  P. Rossini,et al.  Double nerve intraneural interface implant on a human amputee for robotic hand control , 2010, Clinical Neurophysiology.

[3]  S. Cogan.  Neural stimulation and recording electrodes. , 2008, Annual review of biomedical engineering.

[4]  D. Farina,et al.  Online Tremor Suppression Using Electromyography and Low-Level Electrical Stimulation , 2015, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[5]  J. Benito-León,et al.  Essential tremor: emerging views of a common disorder , 2006, Nature Clinical Practice Neurology.

[6]  M. Brin,et al.  Consensus Statement of the Movement Disorder Society on Tremor , 2008, Movement disorders : official journal of the Movement Disorder Society.

[7]  W. Poewe,et al.  Prevalence of movement disorders in men and women aged 50–89 years (Bruneck Study cohort): a population-based study , 2005, The Lancet Neurology.

[8]  R. Elble.  Tremor: clinical features, pathophysiology, and treatment. , 2009, Neurologic clinics.

[9]  T. Stieglitz.  Flexible biomedical microdevices with double-sided electrode arrangements for neural applications , 2001 .

[10]  Hans Dietl,et al.  Fully Implantable Multi-Channel Measurement System for Acquisition of Muscle Activity , 2013, IEEE Transactions on Instrumentation and Measurement.

[11]  Thomas Stieglitz,et al.  “Microflex”—A New Assembling Technique for Interconnects , 2000 .

[12]  T. Stieglitz,et al.  Micromachined, Polyimide-Based Devices for Flexible Neural Interfaces , 2000 .

[13]  Winnie Jensen,et al.  Sampling large populations of motor units in humans with multichannel thin-film electrodes , 2010 .

[14]  S. Micera,et al.  Development, manufacturing and application of double-sided flexible implantable microelectrodes , 2014, Biomedical microdevices.

[15]  R. O’Connor,et al.  Non-pharmacological and non-surgical interventions for tremor: a systematic review. , 2011, Parkinsonism & related disorders.