Correlation of R2 with total iron concentration in the brains of rhesus monkeys

To estimate the relationship between R2 = 1/T2 as measured with a double echo spin echo sequence and total iron concentration in gray matter structures in the brains of aging rhesus monkeys.

[1]  P. Riederer,et al.  Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases? , 1994, Journal of neurochemistry.

[2]  A. Andersen,et al.  Age-associated changes in rhesus CNS composition identified by MRI , 1999, Brain Research.

[3]  P Z Marmarelis,et al.  MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjects. , 1999, Magnetic resonance imaging.

[4]  R G Steen,et al.  Age‐related changes in Brain T1 are correlated with iron concentration , 1998, Magnetic resonance in medicine.

[5]  B. Hallgren,et al.  THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN , 1958, Journal of neurochemistry.

[6]  J. Connor,et al.  A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains , 1992, Journal of neuroscience research.

[7]  R A Brooks,et al.  The quantitative Relation Between T1‐Weighted and T2‐Weighted MRI of Normal gray Matter and iron concentration , 1995, Journal of magnetic resonance imaging : JMRI.

[8]  M. Youdim.  Iron in the brain: implications for Parkinson's and Alzheimer's diseases. , 1988, The Mount Sinai journal of medicine, New York.

[9]  G. Gerhardt,et al.  Motor slowing and parkinsonian signs in aging rhesus monkeys mirror human aging. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[10]  R M Henkelman,et al.  MR of human postmortem brain tissue: correlative study between T2 and assays of iron and ferritin in Parkinson and Huntington disease. , 1993, AJNR. American journal of neuroradiology.

[11]  C. Morris,et al.  Brain iron homeostasis. , 1992, Journal of inorganic biochemistry.

[12]  R D Klausner,et al.  Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. , 1988, Science.

[13]  G. Brittenham,et al.  Noninvasive measurement of iron: report of an NIDDK workshop. , 2003, Blood.

[14]  M. Rayens,et al.  The hexadentate hydroxypyridinonate TREN-(Me-3,2-HOPO) is a more orally active iron chelator than its bidentate analogue. , 2000, Journal of pharmaceutical sciences.

[15]  J. Eaton,et al.  Molecular bases of cellular iron toxicity. , 2002, Free radical biology & medicine.

[16]  K. Jellinger,et al.  The Role of Iron in Neurodegeneration , 1999, Drugs & aging.

[17]  B. Drayer.  Magnetic resonance imaging and extrapyramidal movement disorders. , 1989, European neurology.

[18]  M Gallorini,et al.  Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes , 2001, Journal of neurochemistry.

[19]  Moussa B. H. Youdim,et al.  Brain iron : neurochemical and behavioural aspects , 1988 .

[20]  S. LeVine,et al.  The distribution of iron in the brain: a phylogenetic analysis using iron histochemistry. , 1996, Brain research. Developmental brain research.

[21]  S. Benkovic,et al.  Isoforms of ferritin have a specific cellular distribution in the brain , 1994, Journal of neuroscience research.

[22]  F. Ye,et al.  Estimation of brain iron in vivo by means of the interecho time dependence of image contrast , 1996, Magnetic resonance in medicine.

[23]  Alan P. Koretsky,et al.  MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice , 2003, Brain Research.

[24]  John F. Schenck,et al.  Imaging of brain iron by magnetic resonance: T2 relaxation at different field strengths , 1995, Journal of the Neurological Sciences.

[25]  R. Henkelman.  Measurement of signal intensities in the presence of noise in MR images. , 1985, Medical physics.

[26]  J. Clements.  A statistical test for demonstrating a presynaptic site of action for a modulator of synaptic amplitude , 1990, Journal of Neuroscience Methods.

[27]  N. Olivieri,et al.  Quantification of cardiac and tissue iron by nuclear magnetic resonance relaxometry in a novel murine thalassemia-cardiac iron overload model. , 1996, The Canadian journal of cardiology.

[28]  C D Marsden,et al.  Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. , 1991, Brain : a journal of neurology.

[29]  N. Gelman,et al.  Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: Relation to estimated iron and water contents , 2001, Magnetic resonance in medicine.

[30]  A. Koeppen,et al.  The history of iron in the brain , 1995, Journal of the Neurological Sciences.

[31]  R. Henkelman,et al.  T2 values in the human brain: comparison with quantitative assays of iron and ferritin. , 1989, Radiology.

[32]  G. Buettner,et al.  Catalytic metals, ascorbate and free radicals: combinations to avoid. , 1996, Radiation research.

[33]  R A Knight,et al.  MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content. , 1999, Radiology.

[34]  G. Reynolds,et al.  Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain , 2005, Journal of Neural Transmission.

[35]  G. Bartzokis,et al.  Increased basal ganglia iron levels in Huntington disease. , 1999, Archives of neurology.