Optimisation of global pharmaceutical syntheses integrating environmental aspects

Publisher Summary Pharmaceutical synthesis optimization, because of its complexity, is often reduced to the optimization of the reaction step. This chapter discusses the dynamic model, allowing simulating the different synthesis steps and, particularly start-up and shut-down phases involved. This model connected to an optimization method is able to provide the optimal operating conditions satisfying a global objective. The application to an industrial process highlights the benefits of the proposed methodology. The chapter describes the operating conditions involving the optimization of the global synthesis, satisfying economical and environmental criteria, to develop sustainable methodologies. For this purpose, a framework based on a simulation program, modeling a global synthesis (reaction and separation steps), has been developed. Besides global synthesis treatment, the main features of this work lie in the modeling of batch units and of dynamics, particularly during the start-up and the shut-down involved in the different step.