Exposure method development for risk assessment to cosmetic products using a standard composition.

In a risk assessment of cosmetic products, it is necessary to know both qualitative and quantitative compositions. Currently, European Regulation No. 1223/2009 requires the industries to provide ingredient lists for finished cosmetic products but not their concentrations. Ingredient concentrations are available in few bibliographic references but in an incomplete and approximate way. In this study, we propose a method to qualitatively and quantitatively estimate the composition of a cosmetic product. This method has the advantages of being applicable to all cosmetic products and supplying concentration data for all ingredients. The results obtained seem quite fair compared to literature data. Applied to nail polish as an example, this method can be used to assess exposure per ingredient according to the Monte Carlo probabilistic method. It should be promising to assess the consumer risk to cosmetic product compositions.

[1]  Ord,et al.  Exposure Factors Handbook (2011 Edition) , 2015 .

[2]  M. Gibney,et al.  European consumer exposure to cosmetic products, a framework for conducting population exposure assessments Part 2. , 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[3]  A. M. Api,et al.  Exposure data for cosmetic products: lipstick, body lotion, and face cream. , 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[4]  V Rogiers,et al.  Human health safety evaluation of cosmetics in the EU: a legally imposed challenge to science. , 2010, Toxicology and applied pharmacology.

[5]  R. Baran,et al.  Nail Cosmetics: Handle of Skin Care , 2009 .

[6]  Zoe Diana Draelos,et al.  Handbook of Cosmetic Science and Technology , 2002 .

[7]  Hilko van der Voet,et al.  Integration of Probabilistic Exposure Assessment and Probabilistic Hazard Characterization , 2007, Risk analysis : an official publication of the Society for Risk Analysis.

[8]  S. Yaemsiri,et al.  Growth rate of human fingernails and toenails in healthy American young adults , 2010, Journal of the European Academy of Dermatology and Venereology : JEADV.

[9]  C McNamara,et al.  Probabilistic modelling of European consumer exposure to cosmetic products. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[10]  K J Renskers,et al.  Exposure data for cosmetic products: facial cleanser, hair conditioner, and eye shadow. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[11]  Bremmer Hj,et al.  Cosmetics Fact Sheet. To assess the risks for the consumer. Updated version for ConsExpo 4 , 2006 .

[12]  J. Konz,et al.  Exposure factors handbook , 1989 .

[13]  A. Roudot,et al.  Probabilistic assessment of exposure to nail cosmetics in French consumers. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[14]  C McNamara,et al.  European consumer exposure to cosmetic products, a framework for conducting population exposure assessments. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[15]  H. Maibach,et al.  Handbook of cosmetic science and technology , 2001 .

[16]  Anne Marie Api,et al.  Exposure data for personal care products: hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant. , 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.