Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias.

[1]  C Antzelevitch,et al.  Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle. , 2001, American journal of physiology. Heart and circulatory physiology.

[2]  H. Wellens,et al.  Time course of structural adaptations in chronic AV block dogs: evidence for differential ventricular remodeling. , 2001, American journal of physiology. Heart and circulatory physiology.

[3]  D. Roden.  Pharmacogenetics and drug-induced arrhythmias. , 2001, Cardiovascular research.

[4]  H. Wellens,et al.  Electrophysiological parameters indicative of sudden cardiac death in the dog with chronic complete AV-block. , 2001, Cardiovascular research.

[5]  M. Rosen,et al.  Impact of Sex and Gonadal Steroids on Prolongation of Ventricular Repolarization and Arrhythmias Induced by IK-Blocking Drugs , 2001, Circulation.

[6]  M. Viitasalo,et al.  Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A. , 2001, The American journal of cardiology.

[7]  J. Pezzullo,et al.  Drug-induced QT prolongation in women during the menstrual cycle. , 2001, JAMA.

[8]  M. Yamamoto,et al.  Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole. , 2001, Toxicological sciences : an official journal of the Society of Toxicology.

[9]  M. Vos,et al.  Assessment of the Pro-Arrhythmic Potential of Anti-Arrhythmic Drugs: An Experimental Approach , 2001, Journal of cardiovascular pharmacology and therapeutics.

[10]  H. Wellens,et al.  Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias. , 2001, European journal of pharmacology.

[11]  B. Gorenek,et al.  Observations on the onset of torsade de pointes arrhythmias in the acquired long QT syndrome. , 2000, Cardiovascular research.

[12]  K. Hashimoto,et al.  Proarrhythmic effects of fluoroquinolone antibacterial agents: in vivo effects as physiologic substrate for torsades. , 2000, Toxicology and applied pharmacology.

[13]  S. Nattel.  Acquired delayed rectifier channelopathies: how heart disease and antiarrhythmic drugs mimic potentially-lethal congenital cardiac disorders. , 2000, Cardiovascular Research.

[14]  Hemodynamic and electrophysiologic effects of ontazolast in dogs. , 2000, American journal of veterinary research.

[15]  Jun Chen,et al.  A structural basis for drug-induced long QT syndrome. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[16]  H. Wellens,et al.  Contractile Adaptations Preserving Cardiac Output Predispose the Hypertrophied Canine Heart to Delayed Afterdepolarization–Dependent Ventricular Arrhythmias , 2000, Circulation.

[17]  F. Van de Werf,et al.  Enhanced Ca2 Release and Na/Ca Exchange Activity in Hypertrophied Canine Ventricular Myocytes: Potential Link Between Contractile Adaptation and Arrhythmogenesis , 2000, Circulation.

[18]  D M Roden,et al.  A common polymorphism associated with antibiotic-induced cardiac arrhythmia. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[19]  A. Camm,et al.  Congenital and acquired long QT syndrome. , 2000, European heart journal.

[20]  A. Camm,et al.  The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology. , 2000, Cardiovascular research.

[21]  S. Priori,et al.  Evidence for a Cardiac Ion Channel Mutation Underlying Drug‐Induced QT Prolongation and Life‐Threatening Arrhythmias , 2000, Journal of cardiovascular electrophysiology.

[22]  H. Wellens,et al.  Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts. , 2000, Cardiovascular research.

[23]  C Antzelevitch,et al.  I(NaCa) contributes to electrical heterogeneity within the canine ventricle. , 2000, American journal of physiology. Heart and circulatory physiology.

[24]  W. Kübler,et al.  Cesium chloride induced ventricular arrhythmias in dogs: three-dimensional activation patterns and their relation to the cesium dose applied , 2000, Basic Research in Cardiology.

[25]  C. Antzelevitch,et al.  Transmural Heterogeneity of Ventricular Repolarization Under Baseline and Long QT Conditions in the Canine Heart In Vivo: Torsades de Pointes Develops with Halothane but not Pentobarbital Anesthesia , 2000, Journal of cardiovascular electrophysiology.

[26]  S. A. Chen,et al.  Pro arrhythmic Effects of Ibutilide in a Canine Model of Pacing Induced Cardiomyopathy , 2000, Pacing and clinical electrophysiology : PACE.

[27]  H. Wellens,et al.  Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes. , 1999, Circulation.

[28]  D. Roden,et al.  Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits. , 1999, Circulation.

[29]  S. A. Chen,et al.  Electropharmacologic characteristics of ventricular proarrhythmia induced by ibutilide. , 1999, Journal of cardiovascular pharmacology.

[30]  CHARLES ANTZELEVITCH,et al.  The M Cell: , 1999, Journal of cardiovascular electrophysiology.

[31]  G. Cheymol,et al.  Electrophysiological effects of cetirizine, astemizole and d‐sotalol in a canine model of long QT syndrome , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[32]  G. Tomaselli,et al.  Electrophysiological remodeling in hypertrophy and heart failure. , 1999, Cardiovascular research.

[33]  M. Keating,et al.  MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia , 1999, Cell.

[34]  Wen-Chung Yu,et al.  Effects of 17β‐Estradiol on Tachycardia‐Induced Changes of Atrial Refractoriness and Cisapride‐Induced Ventricular Arrhythmia , 1999, Journal of cardiovascular electrophysiology.

[35]  M Restivo,et al.  Mechanism of arrhythmogenicity of the short-long cardiac sequence that precedes ventricular tachyarrhythmias in the long QT syndrome. , 1999, Journal of the American College of Cardiology.

[36]  T. Mitsui,et al.  QT prolongation and torsades de pointes induced by an antifungal agent, D0870, in conscious dogs. , 1999, Toxicology.

[37]  H. Wellens,et al.  Repolarizing K+ currents ITO1 and IKs are larger in right than left canine ventricular midmyocardium. , 1999, Circulation.

[38]  D. Kass,et al.  Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies. , 1999, Circulation research.

[39]  M van Bilsen,et al.  Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling. , 1998, Circulation.

[40]  H. Wellens,et al.  Cellular basis of biventricular hypertrophy and arrhythmogenesis in dogs with chronic complete atrioventricular block and acquired torsade de pointes. , 1998, Circulation.

[41]  G. Breithardt,et al.  Experimental models of torsade de pointes. , 1998, Cardiovascular research.

[42]  R. Cardinal,et al.  Polymorphic ventricular tachycardias induced by D-sotalol and phenylephrine in canine preparations of atrioventricular block: initiation in the conduction system followed by spatially unstable re-entry. , 1998, Cardiovascular research.

[43]  D. Roden.  Taking the “Idio” out of “Idiosyncratic”: Predicting Torsades de Pointes , 1998, Pacing and clinical electrophysiology : PACE.

[44]  M Restivo,et al.  Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: detailed analysis of ventricular tridimensional activation patterns. , 1997, Circulation.

[45]  P. Coumel,et al.  KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome. , 1997, Circulation.

[46]  H. Wellens,et al.  Further observations to elucidate the role of interventricular dispersion of repolarization and early afterdepolarizations in the genesis of acquired torsade de pointes arrhythmias: a comparison between almokalant and d-sotalol using the dog as its own control. , 1997, Journal of the American College of Cardiology.

[47]  M. Omata,et al.  Three-dimensional activation sequence of cesium-induced ventricular arrhythmias. , 1997, The American journal of physiology.

[48]  K. Ogunyankin,et al.  Antiarrhythmic and Arrhythmogenic Actions of Varying Levels of Extracellular Magnesium: Possible Cellular Basis for the Differences in the Efficacy of Magnesium and Lidocaine in Torsade de Pointes , 1997, Journal of cardiovascular pharmacology and therapeutics.

[49]  D M Roden,et al.  Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells. , 1997, Circulation research.

[50]  H. Wellens,et al.  Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: reversal by magnesium. , 1997, Cardiovascular research.

[51]  M. Lehmann,et al.  Sex difference in risk of torsade de pointes with d,l-sotalol. , 1996, Circulation.

[52]  G Duker,et al.  Rhythm anomalies related to delayed repolarization in vivo: influence of sarcolemmal Ca++ entry and intracellular Ca++ overload. , 1996, The Journal of pharmacology and experimental therapeutics.

[53]  M Restivo,et al.  The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns. , 1996, Circulation research.

[54]  N. Edvardsson,et al.  Torsades de pointes induced by transesophageal atrial stimulation after administration of almokalant. , 1996, International journal of cardiology.

[55]  D. Kass,et al.  Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. , 1996, Circulation research.

[56]  P. Coumel,et al.  Spontaneous sequences of onset of torsade de pointes in patients with acquired prolonged repolarization: quantitative analysis of Holter recordings. , 1995, Journal of the American College of Cardiology.

[57]  C. Antzelevitch,et al.  Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell. , 1995, Circulation research.

[58]  H. Wellens,et al.  The Effect of Flunarizine and Ryanodine on Acquired Torsades de Pointes Arrhythmias in the Intact Canine Heart , 1995, Journal of cardiovascular electrophysiology.

[59]  H. Wellens,et al.  Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. , 1995, Circulation.

[60]  L. Carlsson,et al.  Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations. , 1993, Cardiovascular research.

[61]  C Antzelevitch,et al.  Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. , 1993, Circulation research.

[62]  M. Lehmann,et al.  Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. , 1993, JAMA.

[63]  D. Zipes,et al.  Canine left ventricular hypertrophy predisposes to ventricular tachycardia induction by phase 2 early afterdepolarizations after administration of BAY K 8644. , 1992, Journal of the American College of Cardiology.

[64]  N. El-Sherif,et al.  TU Alternans, Long QTU, and Torsade de Pointes: Clinical and Experimental Observations , 1992 .

[65]  M. Rosen,et al.  T Wave Changes Persisting After Ventricular Pacing in Canine Heart Are Altered by 4‐Aminopyridine But Not by Lidocaine: Implications With Respect to Phenomenon of Cardiac ‘Memory’ , 1992, Circulation.

[66]  J. Davy,et al.  Methods and limitations of an experimental model of long QT syndrome. , 1991, Journal of pharmacological methods.

[67]  L. Carlsson,et al.  QTU‐Prolongation and Torsades de Pointes Induced by Putative Class III Antiarrhythmic Agents in the Rabbit: Etiology and Interventions , 1990, Journal of cardiovascular pharmacology.

[68]  S. Nattel,et al.  Cardiovascular and metabolic effects of caesium chloride injection in dogs--limitations as a model for the long QT syndrome. , 1989, Cardiovascular research.

[69]  M. Rosen,et al.  A Canine Model of Torsades de Pointes , 1988, Pacing and clinical electrophysiology : PACE.

[70]  D P Zipes,et al.  Differential response to right and left ansae subclaviae stimulation of early afterdepolarizations and ventricular tachycardia induced by cesium in dogs. , 1988, Circulation.

[71]  W Craelius,et al.  QTU Prolongation and Polymorphic Ventricular Tachyarrhythmias Due to Bradycardia‐Dependent Early: Afterdepolarizations Afterdepolarizations and Ventricular Arrhythmias , 1988, Circulation research.

[72]  D. Zipes,et al.  Magnesium suppression of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs. , 1988, Circulation.

[73]  J. Spear,et al.  Autonomic modulation of ventricular arrhythmia in cesium chloride-induced long QT syndrome. , 1988, Circulation.

[74]  J. Spear,et al.  Cesium chloride-induced long QT syndrome: demonstration of afterdepolarizations and triggered activity in vivo. , 1985, Circulation.

[75]  G. Kay,et al.  Torsade de pointes: the long-short initiating sequence and other clinical features: observations in 32 patients. , 1983, Journal of the American College of Cardiology.

[76]  R Lazzara,et al.  Bradycardia-dependent triggered activity: relevance to drug-induced multiform ventricular tachycardia. , 1983, Circulation.

[77]  C. N. D'ALNONCOURT,et al.  "Torsade de pointes" tachycardia. Re-entry or focal activity? , 1982, British heart journal.

[78]  D. Fitchett,et al.  "Torsade de pointes" initiated by electrical ventricular stimulation. , 1976, Journal of electrocardiology.

[79]  F Dessertenne,et al.  [Ventricular tachycardia with 2 variable opposing foci]. , 1966, Archives des maladies du coeur et des vaisseaux.

[80]  T. Starzl,et al.  Chronic Heart Block in Dogs. A Method for Producing Experimental Heart Failure , 1955, Circulation.

[81]  T. Starzl,et al.  Acute Complete Heart Block in Dogs , 1955, Circulation.