Medication Nonadherence in Parkinson’s Disease

A number of previously fatal neurological conditions have been rendered treatable, chronic conditions by advances in research. As clinicians delivering a diagnosis such as Parkinson’s Disease (PD) to a concerned patient, we take solace in the knowledge that we have many symptomatic therapies to restore quality of life. Just as we consider the individual’s pertinent symptoms and comorbidities in selecting treatments, we must also consider the prevalence and impact of medication non-adherence. Previously referred to as medication compliance, the term “medication adherence” is preferred as it emphasizes patient autonomy and decision-making (1, 2).

[1]  S. Jain,et al.  Drug related medical emergencies in the elderly: role of adverse drug reactions and non-compliance , 2001, Postgraduate medical journal.

[2]  M. Dimatteo,et al.  Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. , 2000, Archives of internal medicine.

[3]  R B Haynes,et al.  Predicting compliance with a regimen of digoxin therapy in family practice. , 1980, Canadian Medical Association journal.

[4]  G. Nappi,et al.  Drug prescribing patterns in Parkinson's disease: a pharmacoepidemiological survey in a cohort of ambulatory patients , 2002, Pharmacoepidemiology and drug safety.

[5]  C. Viscoli,et al.  Treatment adherence and risk of death after a myocardial infarction , 1990, The Lancet.

[6]  C. Hughes,et al.  Medication Non-Adherence in the Elderly , 2004, Drugs & aging.

[7]  R. Haynes,et al.  Interventions for enhancing medication adherence. , 2008, The Cochrane database of systematic reviews.

[8]  M. Stacy,et al.  Medication adherence and associated outcomes in medicare health maintenance organization‐enrolled older adults with Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[9]  Marcia Polansky,et al.  Drug adherence in Parkinson's disease , 2004, Movement disorders : official journal of the Movement Disorder Society.

[10]  F. Shaya,et al.  Medication Non-adherence is Associated with Increased Medical Health Care Costs , 2008, Digestive Diseases and Sciences.

[11]  Murat Emre,et al.  Parkinson's disease dementia: Definitions, guidelines, and research perspectives in diagnosis , 2008, Annals of neurology.

[12]  Jeffery K. Allen,et al.  Prevalence and cost of medication nonadherence in Parkinson's disease: Evidence from administrative claims data , 2010, Movement disorders : official journal of the Movement Disorder Society.

[13]  I. Bone,et al.  Suboptimal medication adherence in Parkinson's disease , 2005, Movement disorders : official journal of the Movement Disorder Society.

[14]  M. Dubinsky,et al.  Effect of medication dosing frequency on adherence in chronic diseases. , 2009, The American journal of managed care.

[15]  Angelo Antonini,et al.  Adherence to antiparkinson medication in a multicenter European study , 2009, Movement disorders : official journal of the Movement Disorder Society.

[16]  I Bone,et al.  Measuring therapy adherence in Parkinson’s disease: a comparison of methods , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[17]  Haynes Rb,et al.  Interventions for enhancing medication adherence (Review) , 2008 .

[18]  Anette Schrag,et al.  What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them? , 2010, Movement disorders : official journal of the Movement Disorder Society.

[19]  N. Col,et al.  The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. , 1990, Archives of internal medicine.

[20]  Kathleen Insel,et al.  Executive function, working memory, and medication adherence among older adults. , 2006, The journals of gerontology. Series B, Psychological sciences and social sciences.

[21]  Michael J. Miller,et al.  Factors associated with medication refill adherence in cardiovascular-related diseases , 2006, Journal of General Internal Medicine.

[22]  D. Grosset,et al.  Medicine‐taking behavior: Implications of suboptimal compliance in Parkinson's disease , 2005, Movement disorders : official journal of the Movement Disorder Society.

[23]  P. Myint,et al.  The use of carer assisted adherence therapy for people with Parkinson's disease and their carers (CAAT-PARK): study protocol for a randomised controlled trial , 2011, Trials.

[24]  J. Bainbridge,et al.  Challenges of Treatment Adherence in Older Patients with Parkinson’s Disease , 2009, Drugs & aging.

[25]  D. Ose,et al.  Let’s talk about medication: concordance in rating medication adherence among multimorbid patients and their general practitioners , 2012, Patient preference and adherence.

[26]  D. Grosset,et al.  Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial , 2007, BMC neurology.

[27]  Shu-Ya Lu,et al.  Factors associated with adherence to medication regimens in older primary care patients: the Steel Valley Seniors Survey. , 2008, The American journal of geriatric pharmacotherapy.

[28]  Jerry L. Grenard,et al.  A systematic review of barriers to medication adherence in the elderly: looking beyond cost and regimen complexity. , 2011, The American journal of geriatric pharmacotherapy.

[29]  Dag Aarsland,et al.  Neuropsychiatric symptoms in Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[30]  F. Valldeoriola,et al.  Socio‐demographic and clinical factors influencing the adherence to treatment in Parkinson’s disease: the ADHESON study , 2011, European journal of neurology.

[31]  J. Jankovic,et al.  Therapies in Parkinson's disease. , 2012, Current opinion in neurology.