The cytological changes and chemotactic activity in nasal lavage fluid were observed in 27 patients with pollen allergy. In one group of patients Pollinex was administered, but in the second--only placebo. Total cell count in nasal secretions was increased after pollen season. The significant increase of eosinophils and metachromatic cells was observed during the season in comparison with the time before and after it. No seasonal dynamic was documented in chemotactic activity of neutrophils in the nasal lavage fluid. Applied immunotherapy gave a some protection on evaluated parameters and observed symptoms.