Distorted Images of One’s Own Body Activates the Prefrontal Cortex and Limbic/Paralimbic System in Young Women: A Functional Magnetic Resonance Imaging Study

BACKGROUND Our aim was to study the gender differences in brain activation upon viewing visual stimuli of distorted images of one's own body. METHODS We performed functional magnetic resonance imaging on 11 healthy young men and 11 healthy young women using the "body image tasks" which consisted of fat, real, and thin shapes of the subject's own body. RESULTS Comparison of the brain activation upon performing the fat-image task versus real-image task showed significant activation of the bilateral prefrontal cortex and left parahippocampal area including the amygdala in the women, and significant activation of the right occipital lobe including the primary and secondary visual cortices in the men. Comparison of brain activation upon performing the thin-image task versus real-image task showed significant activation of the left prefrontal cortex, left limbic area including the cingulate gyrus and paralimbic area including the insula in women, and significant activation of the occipital lobe including the left primary and secondary visual cortices in men. CONCLUSIONS These results suggest that women tend to perceive distorted images of their own bodies by complex cognitive processing of emotion, whereas men tend to perceive distorted images of their own bodies by object visual processing and spatial visual processing.

[1]  G. Shulman,et al.  Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[2]  P. Strick,et al.  Activation of a cerebellar output nucleus during cognitive processing. , 1994, Science.

[3]  B. Mensour,et al.  Neural circuitry underlying voluntary suppression of sadness , 2003, Biological Psychiatry.

[4]  Janet Treasure,et al.  Functional anatomy of calorie fear in anorexia nervosa , 1998, The Lancet.

[5]  E. Courchesne,et al.  Attentional Activation of the Cerebellum Independent of Motor Involvement , 1997, Science.

[6]  Martin H. Schmidt,et al.  Body image distortion reveals amygdala activation in patients with anorexia nervosa – a functional magnetic resonance imaging study , 2002, Neuroscience Letters.

[7]  C. N. Macrae,et al.  Finding the Self? An Event-Related fMRI Study , 2002, Journal of Cognitive Neuroscience.

[8]  Karl J. Friston,et al.  Dissociable Neural Responses in Human Reward Systems , 2000, The Journal of Neuroscience.

[9]  Evelyn C. Ferstl,et al.  The Anterior Frontomedian Cortex and Evaluative Judgment: An fMRI Study , 2002, NeuroImage.

[10]  R. E. Noble.  Depression in women. , 2005, Metabolism: clinical and experimental.

[11]  Martin H. Schmidt,et al.  Neuronal activity changes and body image distortion in anorexia nervosa , 2003, Neuroreport.

[12]  R. Adolphs,et al.  Fear and the human amygdala , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[13]  J L Lancaster,et al.  Automated Talairach Atlas labels for functional brain mapping , 2000, Human brain mapping.

[14]  Marcus E. Raichle,et al.  Suppression of Regional Cerebral Blood during Emotional versus Higher Cognitive Implications for Interactions between Emotion and Cognition , 1998 .

[15]  Joseph E LeDoux,et al.  Human Amygdala Activation during Conditioned Fear Acquisition and Extinction: a Mixed-Trial fMRI Study , 1998, Neuron.

[16]  Sterling C. Johnson,et al.  Neural correlates of self-reflection. , 2002, Brain : a journal of neurology.

[17]  Karl J. Friston,et al.  How Many Subjects Constitute a Study? , 1999, NeuroImage.

[18]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[19]  Steven C. R. Williams,et al.  Recovery and chronicity in anorexia nervosa brain activity associated with differential outcomes , 2003, Biological Psychiatry.

[20]  B. Vogt,et al.  Contributions of anterior cingulate cortex to behaviour. , 1995, Brain : a journal of neurology.

[21]  R. C. Oldfield.  THE ASSESSMENT AND ANALYSIS OF HANDEDNESS , 1971 .

[22]  R. Adolphs.  Social cognition and the human brain , 1999, Trends in Cognitive Sciences.

[23]  J L Rapoport,et al.  The role of the anterior cingulate in automatic and controlled processes: a developmental neuroanatomical study. , 1997, Developmental psychobiology.

[24]  E. Halgren,et al.  Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala. , 1978, Brain : a journal of neurology.

[25]  A. Dale,et al.  Dorsal anterior cingulate cortex: A role in reward-based decision making , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[27]  R. Dolan,et al.  Conscious and unconscious emotional learning in the human amygdala , 1998, Nature.

[28]  R. Dolan,et al.  Classical fear conditioning in functional neuroimaging , 2000, Current Opinion in Neurobiology.

[29]  Steven C. R. Williams,et al.  Medial prefrontal cortex activity associated with symptom provocation in eating disorders. , 2004, The American journal of psychiatry.

[30]  Yasumasa Okamoto,et al.  Gender differences in brain activity generated by unpleasant word stimuli concerning body image: an fMRI study , 2005, British Journal of Psychiatry.

[31]  M. Olfson,et al.  Depression in women: implications for health care research , 1995, Science.

[32]  Joseph E LeDoux.  Emotion Circuits in the Brain , 2000 .

[33]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[34]  Lisa Weissfeld,et al.  Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness , 2004, Neuropsychopharmacology.

[35]  Leslie G. Ungerleider,et al.  A neural system for human visual working memory. , 1998, Proceedings of the National Academy of Sciences of the United States of America.