Glycocalyx biomarker syndecan‐1 is a stronger predictor of respiratory failure in patients with sepsis due to pneumonia, compared to endocan

[1]  D. Fatovich,et al.  Endothelial glycocalyx biomarkers increase in patients with infection during Emergency Department treatment , 2017, Journal of critical care.

[2]  J. Vincent,et al.  Endocan as an early biomarker of severity in patients with acute respiratory distress syndrome , 2017, Annals of Intensive Care.

[3]  D. Fatovich,et al.  Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis , 2017, Inflammation Research.

[4]  M. Kechagia,et al.  Endocan and the respiratory system: a review , 2016, International journal of chronic obstructive pulmonary disease.

[5]  D. Cornelius,et al.  Plasma syndecan-1 levels identify a cohort of patients with severe sepsis at high risk for intubation after large-volume intravenous fluid resuscitation. , 2016, Journal of critical care.

[6]  R. Leask,et al.  Glycocalyx Degradation Induces a Proinflammatory Phenotype and Increased Leukocyte Adhesion in Cultured Endothelial Cells under Flow , 2016, PloS one.

[7]  Jong Won Kim,et al.  Usefulness of plasma neutrophil gelatinase-associated lipocalin concentration for predicting the severity and mortality of patients with community-acquired pneumonia. , 2016, Clinica chimica acta; international journal of clinical chemistry.

[8]  Michael R Kramer,et al.  Mortality Trends of Acute Respiratory Distress Syndrome in the United States from 1999 to 2013. , 2016, Annals of the American Thoracic Society.

[9]  M. Christ-Crain,et al.  The National Early Warning Score (NEWS) for outcome prediction in emergency department patients with community-acquired pneumonia: results from a 6-year prospective cohort study , 2016, BMJ Open.

[10]  L. M. Srivastava,et al.  Evolution of serum hyaluronan and syndecan levels in prognosis of sepsis patients. , 2016, Clinical biochemistry.

[11]  M. Borggrefe,et al.  Endothelial cell-specific molecule-1/endocan: Diagnostic and prognostic value in patients suffering from severe sepsis and septic shock. , 2016, Journal of critical care.

[12]  G. Bernard,et al.  Clinical Characteristics and Outcomes Are Similar in ARDS Diagnosed by Oxygen Saturation/Fio2 Ratio Compared With Pao2/Fio2 Ratio. , 2015, Chest.

[13]  Xander M R van Wijk,et al.  Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity , 2015, Infection and Immunity.

[14]  N. Dean,et al.  Accuracy of PaO2/FiO2 calculated from SpO2 for severity assessment in ED patients with pneumonia , 2015, Respirology.

[15]  D. Mathieu,et al.  Evaluation of endothelial biomarkers as predictors of organ failures in septic shock patients. , 2015, Cytokine.

[16]  O. Gajic,et al.  SpO2/FiO2 Ratio on Hospital Admission Is an Indicator of Early Acute Respiratory Distress Syndrome Development Among Patients at Risk , 2015, Journal of intensive care medicine.

[17]  P. Pickkers,et al.  Inflammation-Induced Increases in Plasma Endocan Levels are Associated With Endothelial Dysfunction in Humans in vivo , 2015, Shock.

[18]  S. Witkin,et al.  Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections , 2015, Medical Microbiology and Immunology.

[19]  Chun-Sheng Li,et al.  Lactate on emergency department arrival as a predictor of mortality and site-of-care in pneumonia patients: a cohort study , 2015, Thorax.

[20]  C. Pedersen,et al.  Sympathoadrenal activation and endothelial damage in patients with varying degrees of acute infectious disease: an observational study. , 2015, Journal of critical care.

[21]  T. Jenssen,et al.  Syndecan-4 Is a Major Syndecan in Primary Human Endothelial Cells In Vitro, Modulated by Inflammatory Stimuli and Involved in Wound Healing , 2015, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[22]  R. Foster,et al.  Matrix metalloproteinase 9‐mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  Wonhwa Lee,et al.  Endocan Elicits Severe Vascular Inflammatory Responses In Vitro and In Vivo , 2014, Journal of cellular physiology.

[24]  G. Mitić,et al.  Endocan is useful biomarker of survival and severity in sepsis. , 2014, Microvascular research.

[25]  Rhea Bhargava,et al.  Heparanase mediates renal dysfunction during early sepsis in mice , 2013, Physiological reports.

[26]  Shun-Fa Yang,et al.  Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia , 2013, Clinical chemistry and laboratory medicine.

[27]  D. Mathieu,et al.  Identification of a 14 kDa endocan fragment generated by cathepsin G, a novel circulating biomarker in patients with sepsis. , 2013, Journal of pharmaceutical and biomedical analysis.

[28]  C. Carlson,et al.  Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan‐4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure‐overloaded heart , 2013, The FEBS journal.

[29]  P. Rai,et al.  In vivo and in vitro studies on the roles of neutrophil extracellular traps during secondary pneumococcal pneumonia after primary pulmonary influenza infection , 2013, Front. Immunol..

[30]  M. Sallisalmi,et al.  Vascular adhesion protein‐1 and syndecan‐1 in septic shock , 2012, Acta anaesthesiologica Scandinavica.

[31]  P. V. van Eeden,et al.  Critical illness in the emergency department: Lessons learnt from the first 12 months of enrolments in the Critical Illness and Shock Study , 2012, Emergency medicine Australasia : EMA.

[32]  J. Guan,et al.  Enhanced syndecan-1 expression on neutrophils in patients with type 2 diabetes mellitus , 2012, Acta Diabetologica.

[33]  M. Matthay,et al.  The acute respiratory distress syndrome: pathogenesis and treatment. , 2011, Annual review of pathology.

[34]  A. Nagler,et al.  Heparanase Promotes Engraftment and Prevents Graft versus Host Disease in Stem Cell Transplantation , 2010, PloS one.

[35]  A. Norrby-Teglund,et al.  Neutrophil-Derived Hyperresistinemia in Severe Acute Streptococcal Infections1 , 2009, The Journal of Immunology.

[36]  A. Localio,et al.  Lower serum endocan levels are associated with the development of acute lung injury after major trauma. , 2009, Journal of critical care.

[37]  Gordon R Bernard,et al.  Derivation and validation of Spo2/Fio2 ratio to impute for Pao2/Fio2 ratio in the respiratory component of the Sequential Organ Failure Assessment score* , 2009, Critical care medicine.

[38]  A. Schmidtchen,et al.  INCREASED LEVELS OF GLYCOSAMINOGLYCANS DURING SEPTIC SHOCK: RELATION TO MORTALITY AND THE ANTIBACTERIAL ACTIONS OF PLASMA , 2008, Shock.

[39]  C. Owen,et al.  The Sulfate Groups of Chondroitin Sulfate- and Heparan Sulfate-containing Proteoglycans in Neutrophil Plasma Membranes Are Novel Binding Sites for Human Leukocyte Elastase and Cathepsin G* , 2007, Journal of Biological Chemistry.

[40]  A. Lescanic,et al.  Shedding of the Endothelial Glycocalyx in Arterioles, Capillaries and Venules , 2007, American journal of physiology. Heart and circulatory physiology.

[41]  J. Pugin,et al.  Endocan, a new endothelial marker in human sepsis* , 2006, Critical care medicine.

[42]  G. Prestwich,et al.  Regulation of lung injury and repair by Toll-like receptors and hyaluronan , 2005, Nature Medicine.

[43]  A. Schmidt,et al.  Plasmin- and Thrombin-accelerated Shedding of Syndecan-4 Ectodomain Generates Cleavage Sites at Lys114–Arg115 and Lys129–Val130 Bonds* , 2005, Journal of Biological Chemistry.

[44]  L. Szilák,et al.  Interleukin-8 binds to syndecan-2 on human endothelial cells. , 2004, The Biochemical journal.

[45]  W. Lim,et al.  Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study , 2003, Thorax.

[46]  M. Wellner,et al.  Endothelial Cell Specific Molecule-1 - A Newly Identified Protein in Adipocytes , 2003, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[47]  Mitchell M. Levy,et al.  2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference , 2003, Intensive Care Medicine.

[48]  A. Mulivor,et al.  Role of glycocalyx in leukocyte-endothelial cell adhesion. , 2002, American journal of physiology. Heart and circulatory physiology.

[49]  V. Meignin,et al.  Characterization of the Secreted Form of Endothelial-Cell-Specific Molecule 1 by Specific Monoclonal Antibodies , 2000, Journal of Vascular Research.

[50]  Gillian Murphy,et al.  Shedding of Syndecan-1 and -4 Ectodomains Is Regulated by Multiple Signaling Pathways and Mediated by a Timp-3–Sensitive Metalloproteinase , 2000, The Journal of cell biology.

[51]  C. Sprung,et al.  Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. , 1998, Critical care medicine.

[52]  J. Tavernier,et al.  ESM-1 Is a Novel Human Endothelial Cell-specific Molecule Expressed in Lung and Regulated by Cytokines* , 1996, The Journal of Biological Chemistry.

[53]  M. Sallisalmi,et al.  Plasma hyaluronan and hemorheology in patients with septic shock: a clinical and experimental study. , 2014, Clinical hemorheology and microcirculation.

[54]  F. Tacke,et al.  Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity. , 2012, Clinical biochemistry.

[55]  T. Laurent,et al.  Elevated levels of plasma hyaluronan in septicaemia. , 1988, Scandinavian journal of clinical and laboratory investigation.

[56]  C. Mackenzie,et al.  A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. , 1987, Journal of chronic diseases.