The P The effect of metformin plus clomiphene citrate on ovulation and pregnancy rates in clomiphene-resistant women with polycystic ovary syndrome

heterogeneous disorder often associated with obesity, oligomenorrhea, elevated luteinizing hormone (LH) and hyperandrogenemia.1 Insulin resistance is most commonly found in obese PCOS women (65%), but can also be demonstrated in nearly 20% of lean PCOS women.2 It has been suggested that the resulting hyperinsulinemia augments the LH-driven production of androgens from the ovarian theca cells in these women.3 The P The effect of metformin plus clomiphene citrate on ovulation and pregnancy rates in clomiphene-resistant women with polycystic ovary syndrome

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[11]  T. Laatikainen,et al.  Serum levels of insulin‐like growth factor binding protein‐1 and ovulatory responses to clomiphene citrate in women with polycystic ovarian disease , 1994, Fertility and sterility.

[12]  A. Dunaif.  Molecular Mechanisms of Insulin Resistance in the Polycystic Ovary Syndrome , 1994 .

[13]  H. Mason,et al.  Modulation by insulin of follicle-stimulating hormone and luteinizing hormone actions in human granulosa cells of normal and polycystic ovaries. , 1996, The Journal of clinical endocrinology and metabolism.

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