Development of a RadFET linear array for intracavitary in vivo dosimetry in external beam radiotherapy and brachytherapy

We present the details of a new linear array dosimeter consisting of a chain of semiconductors mounted on an ultra-thin (50/spl mu/m thick) flexible substrate and housed in an intracavitary catheter. The semiconductors, manufactured by NMKC Cork, have not been packaged and incorporate a passivation layer that allows them to be mounted on the substrate using flip-chip-bonding. This paper reports, for the first time, the construction of a multiple (ten) detector array suited to in vivo dosimetry in the rectum, esophagus and vagina during external beam radiotherapy, as well as being adaptable to in vivo dosimetry during brachytherapy and diagnostic radiology.

[1]  A Brahme,et al.  Dosimetric precision requirements in radiation therapy. , 1984, Acta radiologica. Oncology.

[2]  Andrew Holmes-Siedle,et al.  Handbook of Radiation Effects , 1993 .

[3]  J Duan,et al.  In vivo urethral dose measurements: a method to verify high dose rate prostate treatments. , 2000, Medical physics.

[4]  D C Weber,et al.  Assessment of target dose delivery in anal cancer using in vivo thermoluminescent dosimetry. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[5]  E. Van Der Schueren,et al.  In vivo dosimetry for tangential breast irradiation: role of the equipment in the accuracy of dose delivery. , 1991, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[6]  Plato C. Lee,et al.  Patient dosimetry quality assurance program with a commercial diode system. , 1994, International journal of radiation oncology, biology, physics.

[7]  Characterisation of radiation response of 400 nm implanted gate oxide RADFETs , 2002, 2002 23rd International Conference on Microelectronics. Proceedings (Cat. No.02TH8595).

[8]  A. Rosenfeld,et al.  MOSFET dosimeters: the role of encapsulation on dosimetric characteristics in mixed gamma-neutron and megavoltage X-ray fields , 1995 .

[9]  M. Butson,et al.  Dose response of various radiation detectors to synchrotron radiation. , 1998, Physics in medicine and biology.

[10]  David J. Kestell,et al.  Novel developments in the MOSFET dosemeter for neutron dosimetry applications. , 2004, Radiation protection dosimetry.

[11]  G. Brucker,et al.  Effects of package geometry, materials, and die design on energy dependence of pMOS dosimeters , 1995 .

[12]  B. Heijmen,et al.  Geometrical uncertainties, radiotherapy planning margins, and the ICRU-62 report. , 2002, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[13]  E. Van Der Schueren,et al.  Importance of in vivo dosimetry as part of a quality assurance program in tangential breast treatments. , 1994, International journal of radiation oncology, biology, physics.

[14]  D Teunen.  The European Directive on health protection of individuals against the dangers of ionising radiation in relation to medical exposures (97/43/EURATOM). , 1998, Journal of radiological protection : official journal of the Society for Radiological Protection.

[15]  C. R. Edwards,et al.  The response of a MOSFET, p-type semiconductor and LiF TLD to quasi-monoenergetic x-rays. , 1997, Physics in medicine and biology.

[16]  G. Rikner,et al.  Silicon diodes as detectors in relative dosimetry of photon, electron and proton radiation fields , 1983 .

[17]  D. Thwaites,et al.  In vivo semiconductor dosimetry as part of routine quality assurance. , 1998, The British journal of radiology.

[18]  T. P. Ma,et al.  Ionizing radiation effects in MOS devices and circuits , 1989 .

[19]  M Goitein,et al.  Calculation of the uncertainty in the dose delivered during radiation therapy. , 1985, Medical physics.

[20]  B J Mijnheer,et al.  In vivo dosimetry during conformal radiotherapy: requirements for and findings of a routine procedure. , 1999, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[21]  L. Adams,et al.  RADFET: A review of the use of metal-oxide-silicon devices as integrating dosimeters , 1986 .

[22]  A Dutreix,et al.  Quality assurance in radiotherapy by in vivo dosimetry. 2. Determination of the target absorbed dose. , 1990, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[23]  D. Bradley,et al.  Development of a Calibration Facility for Test Instrumentation in Diagnostic Radiology , 1996 .

[24]  Richard Pötter,et al.  Physics Aspects of Quality Control in Radiotherapy, Edited by W.P.M. Mayles, R. Lake, A. McKanzie, E.M. Macaulay, H.M. Morgan, T.J. Jordan and S.K. Powley, The Institute of Physics and Engineering in Medicine, York, 1999, 286 pp. ISBN: 0-904181-91-X , 2000 .

[25]  B J Mijnheer,et al.  In vivo dosimetry during external photon beam radiotherapy. , 1999, International journal of radiation oncology, biology, physics.

[26]  J Cygler,et al.  Evaluation of a dual bias dual metal oxide-silicon semiconductor field effect transistor detector as radiation dosimeter. , 1994, Medical physics.

[27]  A B Rosenfeld,et al.  MOSFET dosimetry on modern radiation oncology modalities. , 2002, Radiation protection dosimetry.

[28]  A. Adeyemi,et al.  An audit of radiotherapy patient doses measured with in vivo semiconductor detectors. , 1997, The British journal of radiology.

[29]  E. Iso,et al.  Measurement Uncertainty and Probability: Guide to the Expression of Uncertainty in Measurement , 1995 .

[30]  E. Van Der Schueren,et al.  Quality assurance in radiotherapy by in vivo dosimetry. 1. Entrance dose measurements, a reliable procedure. , 1990, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[31]  Johan Liu,et al.  Anisotropically conductive adhesive flip-chip bonding on rigid and flexible printed circuit substrates , 1996 .

[32]  J. Palta,et al.  Comprehensive QA for radiation oncology: report of AAPM Radiation Therapy Committee Task Group 40. , 1994, Medical physics.

[33]  C. Fiorino,et al.  In-vivo dosimetry by diode semiconductors in combination with portal films during TBI: reporting a 5-year clinical experience. , 1999, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[34]  M. Carolan,et al.  A new radiotherapy surface dose detector:the MOSFET. , 1996, Medical physics.

[35]  J. Barrett,et al.  CHARACTERISATION AND RELIABILITY STUDY OF ANISOTROPIC CONDUCTIVE ADHESIVES FOR FINE PITCH PACKAGE ASSEMBLY , 1995 .