Risk assessment for drug degradation products using physiologically-based pharmacokinetic models
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[1] J. Wilson,et al. Surface area of the small intestine in man. , 1967, Gut.
[2] J. Bridges,et al. Metabolism of aniline in rats, pigs and sheep. , 1978, Drug metabolism and disposition: the biological fate of chemicals.
[3] Joop L. M. Hermens,et al. Determination of octanol/water partition coefficients for hydrophobic organic chemicals with the “slow‐stirring” method , 1989 .
[4] D. Jollow,et al. Use of the NIH shift to determine the relative contribution of competing pathways of aniline metabolism in the rat. , 1986, Drug metabolism and disposition: the biological fate of chemicals.
[5] Harvey J Clewell,et al. A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment. , 2001, Environmental health perspectives.
[6] J. Valentin. Basic anatomical and physiological data for use in radiological protection: reference values , 2002, Annals of the ICRP.
[7] van Boris Wessel Schooten,et al. Development and Specification of Virtual Environments , 2003 .
[8] D. K. Gerken,et al. Toxicity of p-chloroaniline in rats and mice. , 1990, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[9] George Loizou,et al. Physiologically based pharmacokinetic modelling , 2003 .
[10] Virunya S Bhat,et al. Establishing a total allowable concentration of o-toluidine in drinking water incorporating early lifestage exposure and susceptibility. , 2012, Regulatory toxicology and pharmacology : RTP.
[11] J. Popp,et al. Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds. , 1987, Food and Chemical Toxicology.
[12] Poul Thirup,et al. Haematocrit: within-subject and seasonal variation. , 2003, Sports medicine.
[13] R. Billings,et al. Metabolism of acetaminophen and phenacetin by isolated rat hepatocytes. A system in which the spatial organization inherent in the liver is disrupted. , 1985, Drug metabolism and disposition: the biological fate of chemicals.
[14] B Agoram,et al. Predicting the impact of physiological and biochemical processes on oral drug bioavailability. , 2001, Advanced drug delivery reviews.
[15] R. R. Levine. Factors affecting gastrointestinal absorption of drugs , 1970, The American Journal of Digestive Diseases.
[16] J. H. Harrison,et al. Contribution of aniline metabolites to aniline-induced methemoglobinemia. , 1987, Molecular pharmacology.
[17] J B Houston,et al. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. , 1994, Biochemical pharmacology.
[18] K. Pang. Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series). , 2003, Drug metabolism and disposition: the biological fate of chemicals.
[19] J. Gastwirth. Statistical Measures of Earnings Differentials , 1975 .
[20] J. H. Harrison,et al. Role of aniline metabolites in aniline-induced hemolytic anemia. , 1986, The Journal of pharmacology and experimental therapeutics.
[21] G L Amidon,et al. A compartmental absorption and transit model for estimating oral drug absorption. , 1999, International journal of pharmaceutics.
[22] Malcolm Rowland,et al. Tissue lipids and drug distribution: dog versus rat. , 2012, Journal of pharmaceutical sciences.
[23] H Lennernäs,et al. Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach. , 1998, Journal of medicinal chemistry.
[24] John C Lipscomb,et al. Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver. , 2007, Current drug metabolism.