Effects of sex and gender on adaptations to space: reproductive health.

In this report, sex/gender research relevant to reproduction on Earth, in conjunction with the extant human and animal observations in space, was used to identify knowledge gaps and prioritize recommendations for future sex- and gender-specific surveillance and monitoring of male and female astronauts. With overall increased durations of contemporary space missions, a deeper understanding of sex/gender effects on reproduction-related responses and adaptations to the space environment is warranted to minimize risks and insure healthy aging of the men and women who travel into space.

[1]  F. Montorsi,et al.  Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women , 2005, Hormones and Behavior.

[2]  Daniel L. Feeback,et al.  Decreased non-MHC-restricted (CD56+) killer cell cytotoxicity after spaceflight. , 2001, Journal of applied physiology.

[3]  F. Tubach,et al.  Predictive Factors of Early Postoperative Urinary Retention in the Postanesthesia Care Unit , 2005, Anesthesia and analgesia.

[4]  Francis A. Cucinotta,et al.  Physical and Biological Organ Dosimetry Analysis for International Space Station Astronauts , 2008, Radiation research.

[5]  E. Martínez-Conde,et al.  The influence of testosterone in the brain of the male rat on levels of serotonin (5-HT) and hydroxyindole-acetic acid (5-HIAA). , 1985, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

[6]  J. Tash,et al.  Long-term (6-wk) hindlimb suspension inhibits spermatogenesis in adult male rats. , 2002, Journal of applied physiology.

[7]  Dennis Newkirk,et al.  Almanac of Soviet manned space flight , 1989 .

[8]  F. Kim,et al.  Gender Differences among Hispanics and Caucasians in symptomatic presentation of kidney and ureteral stones. , 2005, Journal of endourology.

[9]  J. Massaro,et al.  Clinical comparison of triphasic norgestimate/35 micrograms ethinyl estradiol and monophasic norethindrone acetate/20 micrograms ethinyl estradiol. Cycle control, lipid effects, and user satisfaction. , 1999, Contraception.

[10]  D. Pierson,et al.  Effects of mission duration on neuroimmune responses in astronauts. , 2003, Aviation, space, and environmental medicine.

[11]  K. Schenck-Gustafsson,et al.  Cardiology for gynecologists--a minireview. , 2013, Maturitas.

[12]  F. Turek,et al.  Reproductive hormone replacement alters sleep in mice , 2009, Neuroscience Letters.

[13]  M. Sothmann,et al.  Brain Norepinephrine Changes With Simulated Weightlessness and Relation to Exercise Training , 1999, Physiology & Behavior.

[14]  S. Yamaoka.  Modification of circadian sleep rhythms by gonadal steroids and the neural mechanisms involved , 1980, Brain Research.

[15]  M. Kerkhofs,et al.  Effects of a 3‐week dehydroepiandrosterone administration on sleep, sex steroids and multiple 24‐h hormonal profiles in postmenopausal women: a pilot study , 2013, Clinical endocrinology.

[16]  Cheng Tan,et al.  Changes in the Diurnal Rhythms during a 45-Day Head-Down Bed Rest , 2012, PloS one.

[17]  K. Rothman,et al.  Use of Depot Medroxyprogesterone Acetate Contraception and Incidence of Bone Fracture , 2013, Obstetrics and gynecology.

[18]  C. Kirschbaum,et al.  Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress , 2003, Biological Psychiatry.

[19]  A. Murad.  Contraception in the cosmos: the combined oral contraceptive pill in space , 2008, Journal of Family Planning and Reproductive Health Care.

[20]  C. Lambalk,et al.  The paradox of declining fertility but increasing twinning rates with advancing maternal age. , 2006, Human reproduction.

[21]  G. Bifulco,et al.  Hormonal contraception and bone metabolism: a systematic review. , 2012, Contraception.

[22]  Masahiro Morita,et al.  Histamine Release From the Hypothalamus Induced by Gravity Change in Rats and Space Motion Sickness , 1997, Physiology & Behavior.

[23]  Balwant Rai,et al.  Salivary stress markers and psychological stress in simulated microgravity: 21 days in 6° head-down tilt. , 2011, Journal of oral science.

[24]  K. Matthews,et al.  Sex steroid hormone profiles are related to sleep measures from polysomnography and the Pittsburgh Sleep Quality Index. , 2008, Sleep.

[25]  F. Strollo,et al.  The effect of microgravity on testicular androgen secretion. , 1998, Aviation, space, and environmental medicine.

[26]  L. Brubaker,et al.  Evidence of Uncultivated Bacteria in the Adult Female Bladder , 2012, Journal of Clinical Microbiology.

[27]  Clarence Sams,et al.  Immune system changes during simulated planetary exploration on Devon Island, high arctic , 2007, BMC Immunology.

[28]  P. Luppi,et al.  Oxytocin enhances, and oxytocin antagonism decreases, sexual receptivity in intact female rats , 1994, Neuropeptides.

[29]  J. Grisso,et al.  Sleep Quality, Estradiol Levels, and Behavioral Factors in Late Reproductive Age Women , 2001, Obstetrics and gynecology.

[30]  C. Wade,et al.  Urinary excretion of LH and testosterone from male rats during exposure to increased gravity: post-spaceflight and centrifugation. , 2000, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[31]  W. Hening,et al.  Restless legs syndrome and periodic leg movements in sleep. , 2011, Handbook of clinical neurology.

[32]  C. Kirschbaum,et al.  Impact of oral contraceptive use on glucocorticoid sensitivity of pro-inflammatory cytokine production after psychosocial stress , 2003, Psychoneuroendocrinology.

[33]  S. Bloom,et al.  Orexin A interactions in the hypothalamo-pituitary gonadal axis. , 2001, Endocrinology.

[34]  Victor S. Schneider,et al.  Space, Gravity and the Physiology of Aging: Parallel or Convergent Disciplines? A Mini-Review , 2009, Gerontology.

[35]  M. Ohayon.  Difficulty in resuming or inability to resume sleep and the links to daytime impairment: definition, prevalence and comorbidity. , 2009, Journal of psychiatric research.

[36]  P. Rubin.  Law and order of radiation sensitivity. Absolute versus relative. , 1989, Frontiers of radiation therapy and oncology.

[37]  A. Beaudet,et al.  Chronic estradiol treatment alters central cholinergic function in the female rat: effect on choline acetyltransferase activity, acetylcholine content, and nicotinic autoreceptor function , 1990, Brain Research.

[38]  J Donohoe,et al.  Urinary tract infection in women. , 1995, Irish medical journal.

[39]  J. Sheffield,et al.  Urinary tract infection in women. , 2005, Obstetrics and gynecology.

[40]  D. Suchecki,et al.  Increased ACTH and corticosterone secretion induced by different methods of paradoxical sleep deprivation , 1998, Journal of sleep research.

[41]  K. Walton,et al.  Space flight affects magnocellular supraoptic neurons of young prepuberal rats: transient and permanent effects. , 2001, Brain research. Developmental brain research.

[42]  Eric Boerwinkle,et al.  Hypertension in pregnancy as a risk factor for cardiovascular disease later in life , 2010, Journal of hypertension.

[43]  R. Mattina,et al.  Gender and Age-Dependent Etiology of Community-Acquired Urinary Tract Infections , 2012, TheScientificWorldJournal.

[44]  Chikara Abe,et al.  Long-term hypergravity induces plastic alterations in vestibulo-cardiovascular reflex in conscious rats , 2007, Neuroscience Letters.

[45]  Martina Heer,et al.  Long-duration space flight and bed rest effects on testosterone and other steroids. , 2012, The Journal of clinical endocrinology and metabolism.

[46]  K. Knutson.  Sociodemographic and cultural determinants of sleep deficiency: implications for cardiometabolic disease risk. , 2013, Social science & medicine.

[47]  C. Lushbaugh.  Guidance on Radiation Received in Space Activities , 1990 .

[48]  R. Wu,et al.  Effects of sleep deprivation on serum testosterone concentrations in the rat , 2011, Neuroscience Letters.

[49]  A. R. Elliott,et al.  Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flights. , 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

[50]  J. Liu,et al.  Role of oxytocin in the modulation of ACTH release in women. , 1986, Neuroendocrinology.

[51]  C. Gharib,et al.  Counteraction of spaceflight-induced changes in the rat central serotonergic system by adrenalectomy and corticosteroid replacement , 1998, Neurochemistry International.

[52]  L. Sklar,et al.  GPR30 Expression Is Required for the Mineralocorticoid Receptor–Independent Rapid Vascular Effects of Aldosterone , 2011, Hypertension.

[53]  R. Feldman,et al.  Rapid vascular effects of steroids - a question of balance? , 2010, The Canadian journal of cardiology.

[54]  P. Opstad,et al.  Decreased serum levels of oestradiol, testosterone and prolactin during prolonged physical strain and sleep deprivation, and the influence of a high calory diet , 2004, European Journal of Applied Physiology and Occupational Physiology.

[55]  I. Wiegratz,et al.  Effect of four oral contraceptives on thyroid hormones, adrenal and blood pressure parameters. , 2003, Contraception.

[56]  Francis A. Cucinotta,et al.  Space Radiation Cancer Risk Projections and Uncertainties - 2010 , 2011 .

[57]  J A Jones,et al.  Genitourinary issues during spaceflight: a review , 2005, International Journal of Impotence Research.

[58]  S. Tufik,et al.  Androgen receptor CAG repeat polymorphism is not associated with erectile dysfunction complaints, gonadal steroids, and sleep parameters: data from a population-based survey. , 2011, Journal of andrology.

[59]  B. Nolan.  Sex Steroid Hormone Profiles are Related to Sleep Measures from Polysomnography and the Pittsburgh Sleep Quality Index , 2009 .

[60]  F. Bonnet,et al.  Prevalence of postoperative bladder distension and urinary retention detected by ultrasound measurement. , 2004, British journal of anaesthesia.

[61]  B. McEwen,et al.  Modulation by estradiol of serotonin receptors in brain , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[62]  J. Siegel,et al.  The neurotransmitters of sleep. , 2004, The Journal of clinical psychiatry.