Nonpharmacological treatments for patients with Parkinson's disease

Since 2013, a number of studies have enhanced the literature and have guided clinicians on viable treatment interventions outside of pharmacotherapy and surgery. Thirty‐three randomized controlled trials and one large observational study on exercise and physiotherapy were published in this period. Four randomized controlled trials focused on dance interventions, eight on treatment of cognition and behavior, two on occupational therapy, and two on speech and language therapy (the latter two specifically addressed dysphagia). Three randomized controlled trials focused on multidisciplinary care models, one study on telemedicine, and four studies on alternative interventions, including music therapy and mindfulness. These studies attest to the marked interest in these therapeutic approaches and the increasing evidence base that places nonpharmacological treatments firmly within the integrated repertoire of treatment options in Parkinson's disease. © 2015 International Parkinson and Movement Disorder Society

[1]  G. Earhart,et al.  Are the effects of community-based dance on Parkinson disease severity, balance, and functional mobility reduced with time? A 2-year prospective pilot study. , 2014, Journal of alternative and complementary medicine.

[2]  B. Bloem,et al.  Effectiveness of multidisciplinary care for Parkinson's disease: A randomized, controlled trial , 2013, Movement disorders : official journal of the Movement Disorder Society.

[3]  Andreas Kupsch,et al.  Impact of physical exercise on reaction time in patients with Parkinson's disease-data from the Berlin BIG Study. , 2014, Archives of physical medicine and rehabilitation.

[4]  W. Sturm Cognitive training in Parkinson disease: Cognition-specific vs nonspecific computer training , 2015, Neurology.

[5]  W. H. Staples,et al.  Community-based group exercise for persons with Parkinson disease: a randomized controlled trial. , 2013, NeuroRehabilitation.

[6]  Yvonne M Colgrove,et al.  A randomized controlled pilot study of the therapeutic effects of yoga in people with Parkinson's disease , 2015, International journal of yoga.

[7]  Luca Fiorentini,et al.  Postural rehabilitation and Kinesio taping for axial postural disorders in Parkinson's disease. , 2014, Archives of physical medicine and rehabilitation.

[8]  P. Corbeil,et al.  Effects of 24 wk of treadmill training on gait performance in Parkinson's disease. , 2014, Medicine and science in sports and exercise.

[9]  Yea-Ru Yang,et al.  Combination of rTMS and Treadmill Training Modulates Corticomotor Inhibition and Improves Walking in Parkinson Disease , 2013, Neurorehabilitation and neural repair.

[10]  A. Tröster,et al.  A comparison of Parkinson's disease symptoms and self-reported functioning and well being. , 1997, Parkinsonism & related disorders.

[11]  A. Ridgel,et al.  Enhanced Exercise Therapy in Parkinson’s disease: A comparative effectiveness trial , 2015, Journal of science and medicine in sport / Sports Medicine Australia.

[12]  Nicola Smania,et al.  Robot-assisted gait training versus equal intensity treadmill training in patients with mild to moderate Parkinson's disease: a randomized controlled trial. , 2013, Parkinsonism & related disorders.

[13]  D. Burn,et al.  Cognition in movement disorders: Where can we hope to be in ten years? , 2014, Movement disorders : official journal of the Movement Disorder Society.

[14]  E Libman,et al.  Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease -- a randomized study. , 2013, Parkinsonism & related disorders.

[15]  R. Maestri,et al.  Comparing the effects of hydrotherapy and land-based therapy on balance in patients with Parkinson’s disease: a randomized controlled pilot study , 2014, Clinical rehabilitation.

[16]  Rebecca Stowe,et al.  Physiotherapy versus placebo or no intervention in Parkinson's disease. , 2012, The Cochrane database of systematic reviews.

[17]  M. Fernández-Del-Olmo,et al.  The effects of treadmill or overground walking training program on gait in Parkinson's disease. , 2013, Gait & posture.

[18]  Joe R. Nocera,et al.  The effect of Tai Chi exercise on gait initiation and gait performance in persons with Parkinson's disease. , 2013, Parkinsonism & related disorders.

[19]  Andrea A. Kühn,et al.  Amplitude-oriented exercise in Parkinson’s disease: a randomized study comparing LSVT-BIG and a short training protocol , 2014, Journal of Neural Transmission.

[20]  B. Bloem,et al.  The impact of occupational therapy in Parkinson’s disease: a randomized controlled feasibility study , 2013, Clinical rehabilitation.

[21]  W. Poewe,et al.  The Movement Disorder Society Evidence‐Based Medicine Review Update: Treatments for the non‐motor symptoms of Parkinson's disease , 2011, Movement disorders : official journal of the Movement Disorder Society.

[22]  K. Dashtipour,et al.  Effect of Exercise on Motor and Nonmotor Symptoms of Parkinson's Disease , 2015, Parkinson's disease.

[23]  Jerri D. Edwards,et al.  Randomized trial of cognitive speed of processing training in Parkinson disease , 2013, Neurology.

[24]  Hyun-Seung Song,et al.  Effect of virtual reality dance exercise on the balance, activities of daily living, and depressive disorder status of Parkinson’s disease patients , 2015, Journal of physical therapy science.

[25]  B. Bloem,et al.  Integrated multidisciplinary care in Parkinson's disease: a non-randomised, controlled trial (IMPACT) , 2013, The Lancet Neurology.

[26]  M. Morris,et al.  Dance for people with Parkinson disease: what is the evidence telling us? , 2015, Archives of physical medicine and rehabilitation.

[27]  F. Horak,et al.  Cortical control of postural responses , 2007, Journal of Neural Transmission.

[28]  S. McEwen,et al.  Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease , 2013, The Lancet Neurology.

[29]  P. Parizel,et al.  Mindfulness based intervention in Parkinson's disease leads to structural brain changes on MRI A randomized controlled longitudinal trial , 2013, Clinical Neurology and Neurosurgery.

[30]  J. Laks,et al.  Comparison of strength training, aerobic training, and additional physical therapy as supplementary treatments for Parkinson’s disease: pilot study , 2015, Clinical interventions in aging.

[31]  Pietro Balbi,et al.  The Beneficial Role of Intensive Exercise on Parkinson Disease Progression , 2013, American journal of physical medicine & rehabilitation.

[32]  Houeto Jean-Luc [Parkinson's disease]. , 2022, La Revue du praticien.

[33]  F. Stocchi,et al.  Move for Change Part II: a European survey evaluating the impact of the EPDA Charter for people with Parkinson's disease , 2012, European journal of neurology.

[34]  Roberto Maestri,et al.  Intensive Rehabilitation Treatment in Early Parkinson’s Disease , 2015, Neurorehabilitation and neural repair.

[35]  Giancarlo Ferrigno,et al.  Long-term adaptation of postural control in microgravity , 1999, Experimental Brain Research.

[36]  Bastiaan R Bloem,et al.  Revolutionising management of chronic disease: the ParkinsonNet approach , 2014, BMJ : British Medical Journal.

[37]  M. Mak,et al.  Technology-Assisted Balance and Gait Training Reduces Falls in Patients With Parkinson’s Disease , 2015, Neurorehabilitation and neural repair.

[38]  J. Dukart,et al.  Structural brain plasticity in Parkinson's disease induced by balance training , 2014, Neurobiology of Aging.

[39]  M. Fernández-Del-Olmo,et al.  Treadmill Training Improves Overground Walking Economy in Parkinson’s Disease: A Randomized, Controlled Pilot Study , 2014, Front. Neurol..

[40]  Maria Hagströmer,et al.  The Effects of Highly Challenging Balance Training in Elderly With Parkinson’s Disease , 2015, Neurorehabilitation and neural repair.

[41]  J. Peña,et al.  Improving functional disability and cognition in Parkinson disease , 2014, Neurology.

[42]  Ellen Poliakoff,et al.  The effect of gym training on multiple outcomes in Parkinson's disease: a pilot randomised waiting-list controlled trial. , 2013, NeuroRehabilitation.

[43]  T. Sathyaprabha,et al.  Effect of partial weight-supported treadmill gait training on balance in patients with Parkinson disease. , 2011, PM & R : the journal of injury, function, and rehabilitation.

[44]  W. Poewe,et al.  Management of Motor and Non-Motor Symptoms in Parkinson’s Disease , 2013, CNS Drugs.

[45]  N. Dizdar,et al.  The Ronnie Gardiner Rhythm and Music Method – a feasibility study in Parkinson’s disease , 2013, Disability and rehabilitation.

[46]  Bastiaan R Bloem,et al.  Moving towards patient-centered healthcare for patients with Parkinson's disease. , 2011, Parkinsonism & related disorders.

[47]  P. Trend,et al.  Specialist rehabilitation for people with Parkinson’s disease in the community: a randomised controlled trial , 2014 .

[48]  Elizabeth Eckstrom,et al.  Tai chi and postural stability in patients with Parkinson's disease. , 2012, The New England journal of medicine.

[49]  Quanzheng Li,et al.  Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson’s disease , 2013, Neuroreport.

[50]  David E Vaillancourt,et al.  A two‐year randomized controlled trial of progressive resistance exercise for Parkinson's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[51]  F. Backx,et al.  A personalized coaching program increases outdoor activities and physical fitness in sedentary Parkinson patients; a post-hoc analysis of the ParkFit trial. , 2014, Parkinsonism & related disorders.

[52]  L Mouchnino,et al.  Body orientation and regulation of the center of gravity during movement under water. , 1995, Journal of vestibular research : equilibrium & orientation.

[53]  W. Poewe,et al.  Trial designs used to study neuroprotective therapy in Parkinson's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[54]  B. Bloem,et al.  How to organize multispecialty care for patients with Parkinson's disease. , 2014, Parkinsonism & related disorders.

[55]  Nir Giladi,et al.  Video-assisted swallowing therapy for patients with Parkinson's disease. , 2013, Parkinsonism & related disorders.

[56]  F. Backx,et al.  Promotion of physical activity and fitness in sedentary patients with Parkinson’s disease: randomised controlled trial , 2013, BMJ.

[57]  M. Zigmond,et al.  Exercise: is it a neuroprotective and if so, how does it work? , 2014, Parkinsonism & related disorders.

[58]  Elizabeth Eckstrom,et al.  A Randomized Controlled Trial of Patient-Reported Outcomes With Tai Chi Exercise in Parkinson's Disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[59]  Catherine Sherrington,et al.  Leg muscle power is enhanced by training in people with Parkinson’s disease: a randomized controlled trial , 2014, Clinical rehabilitation.

[60]  Nir Giladi,et al.  Freezing of gait affects quality of life of peoples with Parkinson's disease beyond its relationships with mobility and gait , 2007, Movement disorders : official journal of the Movement Disorder Society.

[61]  Matthew Rizzo,et al.  Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting , 2014, Neurology.

[62]  Ryan P. Duncan,et al.  Community-based Argentine tango dance program is associated with increased activity participation among individuals with Parkinson's disease. , 2013, Archives of physical medicine and rehabilitation.

[63]  R. Marcus,et al.  Exercise and Medication Effects on Persons With Parkinson Disease Across the Domains of Disability: A Randomized Clinical Trial , 2015, Journal of neurologic physical therapy : JNPT.

[64]  Roberto Maestri,et al.  Intensive Rehabilitation Increases BDNF Serum Levels in Parkinsonian Patients , 2014, Neurorehabilitation and neural repair.

[65]  G Ferrigno,et al.  Static and dynamic postural control in long-term microgravity: evidence of a dual adaptation. , 2001, Journal of applied physiology.

[66]  Rebecca Stowe,et al.  Physiotherapy for Parkinson's disease: a comparison of techniques. , 2014, The Cochrane database of systematic reviews.

[67]  T. Simuni,et al.  Back to the basics: regular exercise matters in parkinson's disease: results from the National Parkinson Foundation QII registry study. , 2014, Parkinsonism & related disorders.

[68]  D. Burn,et al.  Guided self-help for the management of worry in Parkinson's disease: a pilot study. , 2013, Journal of Parkinson's disease.

[69]  Natalie E. Allen,et al.  Exercise for falls prevention in Parkinson disease , 2015, Neurology.

[70]  N. Gasson,et al.  A waitlist-controlled trial of group cognitive behavioural therapy for depression and anxiety in Parkinson’s disease , 2014, BMC Psychiatry.

[71]  R. Speyer,et al.  Surface electrical stimulation in dysphagic parkinson patients: A randomized clinical trial , 2013, The Laryngoscope.

[72]  Yoshihiro Miyake,et al.  Interactive Rhythmic Cue Facilitates Gait Relearning in Patients with Parkinson's Disease , 2013, PloS one.

[73]  Economic evaluation of occupational therapy in Parkinson's disease: A randomized controlled trial , 2015, Movement disorders : official journal of the Movement Disorder Society.

[74]  Kelly L. Sullivan,et al.  Initial Management of Parkinson’s Disease , 2002 .

[75]  M. Morris,et al.  Is Irish set dancing feasible for people with Parkinson's disease in Ireland? , 2015, Complementary therapies in clinical practice.

[76]  M. Morris,et al.  A comparison of Irish set dancing and exercises for people with Parkinson’s disease: A phase II feasibility study , 2013, BMC Geriatrics.

[77]  John D Sorkin,et al.  Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease. , 2013, JAMA neurology.

[78]  Bastiaan R Bloem,et al.  Efficacy of occupational therapy for patients with Parkinson's disease: a randomised controlled trial , 2014, The Lancet Neurology.

[79]  Michael T. Bull,et al.  Randomized Controlled Clinical Trial of 'Virtual House Calls' for Parkinson Disease , 2013, JAMA neurology.

[80]  L. King,et al.  Effects of exercise on mobility in people with Parkinson's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[81]  Marjan Jahanshahi,et al.  Postural instability and falls in Parkinson’s disease , 2016, Reviews in the neurosciences.

[82]  V. Sossi,et al.  Trials of neuroprotective therapies for Parkinson's disease: problems and limitations. , 2010, Parkinsonism & related disorders.

[83]  A. David,et al.  Trial of CBT for impulse control behaviors affecting Parkinson patients and their caregivers , 2013, Neurology.

[84]  Madeleine. E. Hackney,et al.  The Effects of Adapted Tango on Spatial Cognition and Disease Severity in Parkinson's Disease , 2013, Journal of motor behavior.

[85]  A. Wehr,et al.  Effects of a formal exercise program on Parkinson's disease: a pilot study using a delayed start design. , 2014, Parkinsonism & related disorders.