Evaluation of a Propofol and Remifentanil interaction model for predictive control of anesthesia induction

This paper introduces a simplified linear interaction model between two drugs, namely Propofol and Remifentanil, which will be used in a model based predictive control algorithm for (nonlinear) automatic induction and regulation of DOA. Depth of anesthesia (DOA) is evaluated by means of the Bispectral index (BIS). The simulation tests are performed on a set of 24 virtually generated realistic patient models. The results are promising and the performance of the controller shows a high-efficiency, optimal dosage of the two drugs in order to achieve the desired BIS reference.

[1]  Robin De Keyser,et al.  Variable Time-Delay Estimation for Anesthesia Control During Intensive Care , 2011, IEEE Transactions on Biomedical Engineering.

[2]  Olaf Simanski,et al.  Progress of automatic drug delivery in anaesthesia—The ‘Rostock assistant system for anaesthesia control (RAN)’ , 2008 .

[3]  J. Bruhn,et al.  Depth of anaesthesia monitoring: what's available, what's validated and what's next? , 2006, British journal of anaesthesia.

[4]  Efstratios N. Pistikopoulos,et al.  Modelling and control of drug delivery systems , 2005, Comput. Chem. Eng..

[5]  G Rolly,et al.  Closed‐loop controlled administration of propofol using bispectral analysis , 1998, Anaesthesia.

[6]  Julio E. Normey-Rico,et al.  Robust Predictive Control Strategy Applied for Propofol Dosing Using BIS as a Controlled Variable During Anesthesia , 2008, IEEE Transactions on Biomedical Engineering.

[7]  Thomas W. Schnider,et al.  Pharmacokinetics and Pharmacodynamics of Remifentanil: II. Model Application , 1997, Anesthesiology.

[8]  Hugo Vereecke,et al.  Ability of the Bispectral Index, Autoregressive Modelling with Exogenous Input-derived Auditory Evoked Potentials, and Predicted Propofol Concentrations to Measure Patient Responsiveness during Anesthesia with Propofol and Remifentanil , 2003, Anesthesiology.

[9]  S L Shafer,et al.  The influence of age on propofol pharmacodynamics. , 1999, Anesthesiology.

[10]  Gade Pandu Rangaiah,et al.  Advanced Control Strategies for the Regulation of Hypnosis with Propofol , 2009 .

[11]  João M. Lemos,et al.  Feedforward adaptive control of the Bispectral Index of the EEG using the intravenous anaesthetic dr , 2008 .

[12]  S. Shafer,et al.  The Influence of Method of Administration and Covariates on the Pharmacokinetics of Propofol in Adult Volunteers , 1998, Anesthesiology.

[13]  Thomas W. Schnider,et al.  Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development , 1997 .

[14]  T. Bouillon.  Hypnotic and opioid anesthetic drug interactions on the CNS, focus on response surface modeling. , 2008, Handbook of experimental pharmacology.

[15]  N. Morton,et al.  Pharmacokinetic model driven infusion of propofol in children. , 1991, British journal of anaesthesia.

[16]  S L Shafer,et al.  Pharmacokinetics and Pharmacodynamics of Remifentanil: II. Model Application , 1997, Anesthesiology.