论文信息 - OROTIC ACID AND ITS ANALOGUES: PART II. ON THE ALKALINE REARRANGEMENT OF 5-CARBOXYMETHYLIDENEHYDANTOIN

OROTIC ACID AND ITS ANALOGUES: PART II. ON THE ALKALINE REARRANGEMENT OF 5-CARBOXYMETHYLIDENEHYDANTOIN

The in vitro conversion of 5-carboxymethylidenehydantoin to orotic acid is not likely to occur in vivo since the two substances have antagonistic effects (2). A sulphur analogue of the above hydantoin has been prepared and shown not to undergo alkaline rearrangement to the corresponding metathiazine structure. The mechanism of orotic acid formation is discussed.

R. Deghenghi | G. Daneault

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