Treatment of established osteoporosis: a systematic review and cost-utility analysis.

Authors' conclusions Cost-effective scenarios for several interventions in the management of established osteoporosis were identified. Costeffectiveness ratios decrease with age. At age 50 years, only HRT and calcium plus vitamin D were cost-effective (assuming that the agent would decrease the risk of appendicular fractures at this age). At age 80 years, HRT, calcium with or without vitamin D, alfacalcidol, alendronate and bisphosphonate were all cost-effective.

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