Portal pyaemia as a presenting feature of paediatric crohn disease.

Thromboembolic complications of inflammatory bowel diseases (IBD) are well recognised and associated with a high mortality (1). Portal vein thrombosis is a rare and serious complication especially when associated with sepsis (portal pylephlebitis). Whilst it is a wellrecognised complication of Crohn disease in adults, only in 1 case has it been reported as the presenting feature (2). In paediatric practice, there is only 1 case report of this complication in an 18-year-old patient 8 years after diagnosis. We present a 14-year-old girl who presented to our unit with sepsis, jaundice and massive weight loss. Septic thrombophlebitis of the portal vein was diagnosed by abdominal computerised tomography (CT). Further investigation demonstrated she had Crohn disease. She was successfully treated with antibiotics, anticoagulants and surgical resection of affected bowel. To our knowledge, this is the first reported child who has Crohn disease presenting with portal vein pylephlebitis.

[1]  P. Berry,et al.  Unrecognized pylephlebitis causing life-threatening septic shock: a case report. , 2005, World journal of gastroenterology.

[2]  K. Sugimachi,et al.  Portal vein thrombosis complicated with disseminated intravascular coagulation due to acute cholecystitis. , 2004, Hepato-Gastroenterology.

[3]  G. Lycklama,et al.  Sepsis and elevated liver enzymes in a patient with inflammatory bowel disease: think of portal vein thrombosis. , 2004, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[4]  K. Hirata,et al.  Septic Thrombophlebitis of the Portal and Superior Mesenteric Veins as a Complication of Appendicitis: Report of a Case , 2004, Surgery Today.

[5]  J. Bode,et al.  Thrombolytic therapy in patients with portal vein thrombosis: case report and review of the literature. , 2000, European journal of gastroenterology & hepatology.

[6]  J. Baddley,et al.  Crohn's disease presenting as septic thrombophlebitis of the portal vein (pylephlebitis): case report and review of the literature , 1999, American Journal of Gastroenterology.

[7]  C. Liacouras,et al.  Portal-mesenteric pylephlebitis with hepatic abscesses in a patient with Crohn's disease treated successfully with anticoagulation and antibiotics. , 1996, Journal of pediatric gastroenterology and nutrition.

[8]  R. Beart,et al.  Vascular complications of inflammatory bowel disease. , 1986, Mayo Clinic proceedings.

[9]  J. Adelson,et al.  Thrombosis as a complication of inflammatory bowel disease in children: a report of four cases. , 1985, Journal of pediatric gastroenterology and nutrition.

[10]  H. Janowitz,et al.  Suppurative pylephlebitis with multiple liver abscesses complicating regional ileitis: review of literature--1940-1960. , 1962, Annals of surgery.

[11]  F. W. Taylor Regional enteritis complicated by pylephlebitis and multiple liver abscesses. , 1949, The American journal of medicine.