Gastric adenocarcinoma with ossification in a ferret (Mustela putorius furo).

A 6-year-old female ferret had a firm mass 2 cm in diameter in the pyloric region of the stomach. Histopathologically, the mass was composed of neoplastic proliferation of well-differentiated epithelial cells, showing tubular or glandular growth patterns. Osseous metaplastic foci were often found in the tumor. Tumor cells showed a positive reaction for immunohistochemistry against bone morphogenetic protein-6, an osteogenic factor. A diagnosis of gastric adenocarcinoma with ossification was made.

[1]  K. Uchida,et al.  Expression of Bone Morphogenetic Protein-6 and Bone Morphogenetic Protein Receptors in Myoepithelial Cells of Canine Mammary Gland Tumors , 2004, Veterinary pathology.

[2]  S. Hatakeyama,et al.  Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification , 2001, Pathology international.

[3]  B. Hogan,et al.  Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland. , 1999, Cancer research.

[4]  F. Hamdy,et al.  Bone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignancies. , 1998, British Journal of Cancer.

[5]  D. Goltzman.  Mechanisms of the development of osteoblastic metastases , 1997, Cancer.

[6]  F. Hamdy,et al.  Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue. , 1997, Cancer research.

[7]  J. Fox,et al.  Helicobacter mustelae-associated Gastric Adenocarcinoma in Ferrets (Mustela putorius furo) , 1997, Veterinary pathology.

[8]  V. Clyde,et al.  Two cases of pyloric adenocarcinoma in the ferret (Mustela putorius furo) , 1995, Veterinary Record.

[9]  W. Pledger,et al.  Expression and growth inhibitory effect of decapentaplegic Vg-related protein 6: evidence for a regulatory role in keratinocyte differentiation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Kitazawa,et al.  Parathyroid hormone‐related protein in gastric cancers with heterotopic ossification , 1993, Cancer.

[11]  S. Tannenbaum,et al.  MNNG-induced gastric carcinoma in ferrets infected with Helicobacter mustelae. , 1993, Carcinogenesis.

[12]  McLeod Cg,et al.  Pyloric adenocarcinoma in a ferret. , 1992, Journal of the American Veterinary Medical Association.

[13]  J. Fox,et al.  Helicobacter mustelae-associated gastritis in ferrets , 1990 .