Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo

[1]  G. Bourret,et al.  Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice. , 2011, American journal of physiology. Endocrinology and metabolism.

[2]  J. Condeelis,et al.  An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. , 2011, Cancer research.

[3]  J. Condeelis,et al.  Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes. , 2011, European journal of cell biology.

[4]  A. Boggs,et al.  c-Src differentially regulates the functions of microtentacles and invadopodia , 2010, Oncogene.

[5]  S. Weed,et al.  Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation , 2010, Journal of Cell Science.

[6]  A. Pendergast,et al.  Abl Kinases Are Required for Invadopodia Formation and Chemokine-induced Invasion* , 2010, The Journal of Biological Chemistry.

[7]  D. W. Kim,et al.  Elevated c-Src and c-Yes expression in malignant skin cancers , 2010, Journal of experimental & clinical cancer research : CR.

[8]  W. Kolch,et al.  The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway. , 2010, Cellular signalling.

[9]  T. Majima,et al.  Adaptor Protein Crk Induces Src-Dependent Activation of p38 MAPK in Regulation of Synovial Sarcoma Cell Proliferation , 2009, Molecular Cancer Research.

[10]  S. Stylli,et al.  Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation , 2009, Journal of Cell Science.

[11]  A. Huttenlocher,et al.  FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion , 2009, The Journal of cell biology.

[12]  B. Mayer,et al.  A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors , 2008, Journal of Cell Science.

[13]  A. Luini,et al.  Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation , 2008, Journal of Cell Science.

[14]  Thamara K. Dayarathna,et al.  Phosphorylated YDXV Motifs and Nck SH2/SH3 Adaptors Act Cooperatively To Induce Actin Reorganization , 2008, Molecular and Cellular Biology.

[15]  L. Larue,et al.  Cutaneous melanoma in genetically modified animals. , 2007, Pigment cell research.

[16]  K. Flaherty,et al.  Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels , 2007, British Journal of Cancer.

[17]  Wen-Lin Kuo,et al.  A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. , 2006, Cancer cell.

[18]  Jean-Philippe Brunet,et al.  The melanocyte differentiation program predisposes to metastasis after neoplastic transformation , 2005, Nature Genetics.

[19]  U. Weidle,et al.  Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays , 2005, British Journal of Cancer.

[20]  Wenjun Guo,et al.  Integrin signalling during tumour progression , 2004, Nature Reviews Molecular Cell Biology.

[21]  Roberto Buccione,et al.  Foot and mouth: podosomes, invadopodia and circular dorsal ruffles , 2004, Nature Reviews Molecular Cell Biology.

[22]  M. McNiven,et al.  The role of dynamin in the assembly and function of podosomes and invadopodia. , 2004, Frontiers in bioscience : a journal and virtual library.

[23]  M. Lacroix,et al.  Relevance of Breast Cancer Cell Lines as Models for Breast Tumours: An Update , 2004, Breast Cancer Research and Treatment.

[24]  J. Segall,et al.  Intravital imaging of cell movement in tumours , 2003, Nature Reviews Cancer.

[25]  Guido Tarone,et al.  Positional control of cell fate through joint integrin/receptor protein kinase signaling. , 2003, Annual review of cell and developmental biology.

[26]  Martin Fussenegger,et al.  Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. , 2003, Biotechnology and bioengineering.

[27]  T. Pawson,et al.  The Murine Nck SH2/SH3 Adaptors Are Important for the Development of Mesoderm-Derived Embryonic Structures and for Regulating the Cellular Actin Network , 2003, Molecular and Cellular Biology.

[28]  T. Kennedy,et al.  The Adaptor Protein Nck-1 Couples the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) to the Activation of the Small GTPase Rac1 through an Atypical Mechanism* , 2002, The Journal of Biological Chemistry.

[29]  L. Buday,et al.  The Nck family of adapter proteins: regulators of actin cytoskeleton. , 2002, Cellular signalling.

[30]  J. Guan,et al.  Nck-2 interacts with focal adhesion kinase and modulates cell motility. , 2002, International Journal of Biochemistry and Cell Biology.

[31]  Lida Guo,et al.  A Critical Role of the PINCH-Integrin-linked Kinase Interaction in the Regulation of Cell Shape Change and Migration* , 2002, The Journal of Biological Chemistry.

[32]  S. Philippou,et al.  Modulation of angiogenesis and tumorigenicity of human melanocytic cells by vascular endothelial growth factor and basic fibroblast growth factor. , 2001, Cancer research.

[33]  Chad A. Cowan,et al.  The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals , 2001, Nature.

[34]  W. Li,et al.  The SH2 and SH3 adapter Nck: a two-gene family and a linker between tyrosine kinases and multiple signaling networks. , 2000, Histology and histopathology.

[35]  B. Mayer,et al.  Activation of the Abl Tyrosine Kinase in Vivo by Src Homology 3 Domains from the Src Homology 2/Src Homology 3 Adaptor Nck* , 1999, The Journal of Biological Chemistry.

[36]  L. Buday,et al.  Membrane-targeting of signalling molecules by SH2/SH3 domain-containing adaptor proteins. , 1999, Biochimica et biophysica acta.

[37]  S. Aota,et al.  Molecular diversity of cell-matrix adhesions. , 1999, Journal of cell science.

[38]  Y. Tu,et al.  The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells , 1999, Molecular and Cellular Biology.

[39]  L. Quilliam,et al.  Identification of Grb4/Nckβ, a Src Homology 2 and 3 Domain-containing Adapter Protein Having Similar Binding and Biological Properties to Nck* , 1999, The Journal of Biological Chemistry.

[40]  Y. Tu,et al.  Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. , 1998, Molecular biology of the cell.

[41]  J. McCarty,et al.  The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events , 1998, BioEssays : news and reviews in molecular, cellular and developmental biology.

[42]  Gerhard Christofori,et al.  A causal role for E-cadherin in the transition from adenoma to carcinoma , 1998, Nature.

[43]  A. Lane,et al.  Nck Recruitment to Eph Receptor, EphB1/ELK, Couples Ligand Activation to c-Jun Kinase* , 1998, The Journal of Biological Chemistry.

[44]  T. Pawson,et al.  Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells , 1997, The EMBO journal.

[45]  L. Larose,et al.  A Casein Kinase I Activity Is Constitutively Associated with Nck* , 1997, The Journal of Biological Chemistry.

[46]  D. Lawe,et al.  The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68 , 1997, Oncogene.

[47]  T. Yoneda,et al.  E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. , 1996, Cancer research.

[48]  A. Horwitz,et al.  Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions , 1995, The Journal of cell biology.

[49]  F. Giancotti,et al.  Integrin-mediated adhesion and signaling in tumorigenesis. , 1994, Biochimica et biophysica acta.

[50]  I. G. Fantus,et al.  Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. , 1994, The Journal of biological chemistry.

[51]  M. White,et al.  Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R L Juliano,et al.  Adhesion molecules in cancer: the role of integrins. , 1993, Current opinion in cell biology.

[53]  S. Rhee,et al.  Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP , 1992, Molecular and cellular biology.

[54]  T. Hunter,et al.  The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment , 1992, Molecular and cellular biology.

[55]  H. Hanafusa,et al.  The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. , 1992, Molecular and cellular biology.

[56]  A. Ullrich,et al.  The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors , 1992, Molecular and cellular biology.

[57]  Richard O. Hynes,et al.  Integrins: Versatility, modulation, and signaling in cell adhesion , 1992, Cell.

[58]  W. Birchmeier,et al.  E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells , 1991, The Journal of cell biology.

[59]  J. Lehmann,et al.  Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3. , 1990, Nucleic acids research.

[60]  I. G. Fantus,et al.  Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase. , 1989, Biochemistry.

[61]  W. T. Chen,et al.  Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells. , 1989, The Journal of experimental zoology.

[62]  W. Clark,et al.  Inhibition of metastases of a human melanoma xenograft by monoclonal antibody to the GD2/GD3 gangliosides. , 1989, Journal of the National Cancer Institute.

[63]  I. G. Fantus,et al.  Peroxide(s) of vanadium: a novel and potent insulin-mimetic agent which activates the insulin receptor kinase. , 1987, Biochemical and biophysical research communications.

[64]  M. Brattain,et al.  Establishment of mouse colonic carcinoma cell lines with different metastatic properties. , 1980, Cancer research.

[65]  J. Garland The New England Journal of Medicine. , 1961, Canadian Medical Association journal.

[66]  J.,et al.  The New England Journal of Medicine , 2012 .

[67]  J. Segall,et al.  Molecular mechanisms of invadopodium formation: the role of the N-WASP–Arp2/3 complex pathway and cofilin , 2005 .

[68]  P. Meltzer,et al.  High frequency of BRAF mutations in nevi , 2003, Nature Genetics.

[69]  S. Dedhar,et al.  Mini-Review Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling , 2001 .

[70]  M. Takeichi Morphogenetic roles of classic cadherins. , 1995, Current opinion in cell biology.

[71]  B. Mayer,et al.  Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C. , 1988, Cold Spring Harbor symposia on quantitative biology.