Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus.

Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.

[1]  J. Thompson,et al.  Biochemical and physiochemical characteristics of a pre-B cell stimulating factor produced by the plasmacytoma cell line LICR LON HMY2. , 1985, Clinical and experimental immunology.

[2]  J. Thompson,et al.  Human B cell colony growth from pre-B cells in vitro. , 1985, Clinical and experimental immunology.

[3]  W. Stohl.  Deficient OKT4 epitope on helper T cells in patient with SLE: confusion with AIDS. , 1984, The New England journal of medicine.

[4]  A. Steinberg,et al.  Systemic Lupus Erythematosus: Insights from Animal Models , 1984 .

[5]  A. Steinberg,et al.  Recent advances in SLE , 1984 .

[6]  E. Reinherz,et al.  Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions. , 1984, The Journal of clinical investigation.

[7]  G. Tsokos,et al.  T and B lymphocyte function in patients with lupus nephritis: correlation with renal pathology. , 1984, Clinical nephrology.

[8]  G. Kammer,et al.  Impaired immunoregulation in systemic lupus erythematosus: defective adenosine-induced suppressor T lymphocyte generation. , 1983, Journal of immunology.

[9]  G. Tsokos,et al.  Phenotypes of T lymphocytes in systemic lupus erythematosus: decreased cytotoxic/suppressor subpopulation is associated with deficient allogeneic cytotoxic responses rather than with concanavalin A-induced suppressor cells. , 1983, Clinical immunology and immunopathology.

[10]  A. Steinberg,et al.  Correlation between clinical activity of systemic lupus erythematosus and the amounts of DNA in DNA/anti-DNA antibody immune complexes. , 1982, Journal of immunology.

[11]  J F Fries,et al.  The 1982 revised criteria for the classification of systemic lupus erythematosus. , 1982, Arthritis and rheumatism.

[12]  R. Whisler,et al.  Characteristics and differential T-cell dependency of human B-cell colony precursors. , 1982, Cellular immunology.

[13]  E. Reinherz,et al.  Comparison in T- and B-cell markers in patients with Sjögren's syndrome and systemic lupus erythematosus. , 1982, Clinical immunology and immunopathology.

[14]  A. Steinberg,et al.  Defective regulation of B lymphocyte colony formation in patients with systemic lupus erythematosus. , 1982, Journal of immunology.

[15]  G. Tsokos,et al.  Spontaneous and pokeweed mitogen-induced plaque-forming cells in systemic lupus erythematosus. , 1981, Clinical immunology and immunopathology.

[16]  K. Ault,et al.  Human B lymphocyte subsets. I. IgG-bearing B cell response to pokeweed mitogen , 1981, The Journal of experimental medicine.

[17]  T. Kishimoto,et al.  In vitro immune response of human peripheral lymphocytes. VI. Distribution and characterization of precursors for PHA- and protein A-induced colony-forming B cells. , 1980, Journal of immunology.

[18]  A. Steinberg,et al.  Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus erythematosus. , 1980, The American journal of medicine.

[19]  D. Thomas,et al.  In vivo cyclic change in B-lymphocyte susceptibility to T-cell control , 1980, Nature.

[20]  K. Siminovitch,et al.  Immune Regulatory Abnormalities in Systemic Lupus Erythematosus , 1983 .

[21]  A. Fauci,et al.  Human B-lymphocyte function : activation and immunoregulation , 1982 .

[22]  T. Waldmann,et al.  Polyclonal B-cell activators in the study of the regulation of immunoglobulin synthesis in the human system. , 1982, Advances in immunology.

[23]  I. Mackay,et al.  T lymphocyte subpopulations defined by two sets of monoclonal antibodies in chronic active hepatitis and systemic lupus erythematosus. , 1982, Clinical and experimental immunology.

[24]  P. Lipsky,et al.  Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus. , 1979, Clinical and experimental immunology.