LEAPing through the looking glass: secondary analysis of the effect of skin test size and age of introduction on peanut tolerance after early peanut introduction

In the Learning Early About Peanut Allergy (LEAP) study, early peanut introduction in high‐risk 4‐ to 11‐month‐olds was associated with a significantly decreased risk of developing peanut allergy. However, the influences of key baseline high‐risk factors on peanut tolerance are poorly understood.

[1]  A. Sanabria,et al.  Randomized controlled trial. , 2005, World journal of surgery.

[2]  Matthew Greenhawt,et al.  The Learning Early About Peanut Allergy Study: The Benefits of Early Peanut Introduction, and a New Horizon in Fighting the Food Allergy Epidemic. , 2015, Pediatric clinics of North America.

[3]  S. Spector,et al.  Allergy diagnostic testing: An updated practice parameter (Annals of Allergy, Asthma and Immunology (2008) 100, SUPPL. 3, (S1-S148)) , 2008 .

[4]  H. Sampson,et al.  Preventing peanut allergy through early consumption--ready for prime time? , 2015, The New England journal of medicine.

[5]  Scott H Sicherer,et al.  Food allergy: a practice parameter update-2014. , 2014, The Journal of allergy and clinical immunology.

[6]  C. West,et al.  Early regular egg exposure in infants with eczema: A randomized controlled trial. , 2013, The Journal of allergy and clinical immunology.

[7]  Linda Cox,et al.  Allergy diagnostic testing: an updated practice parameter. , 2008, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[8]  S. Luccioli,et al.  Infant Feeding Practices and Reported Food Allergies at 6 Years of Age , 2014, Pediatrics.

[9]  G. Lack,et al.  Peanut consumption in infants at risk for peanut allergy. , 2015, The New England journal of medicine.

[10]  A. Litonjua,et al.  Peanut allergy prevalence among school-age children in a US cohort not selected for any disease. , 2014, The Journal of allergy and clinical immunology.

[11]  A. Ponsonby,et al.  Can early introduction of egg prevent egg allergy in infants? A population-based study. , 2010, The Journal of allergy and clinical immunology.

[12]  B. Higgins,et al.  Time trends in the prevalence of peanut allergy: three cohorts of children from the same geographical location in the UK , 2010, Allergy.

[13]  C. Flohr,et al.  Enquiring About Tolerance (EAT) study: Feasibility of an early allergenic food introduction regimen , 2016, The Journal of allergy and clinical immunology.

[14]  K. Maslin,et al.  The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart , 2016, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[15]  M. Cabana,et al.  The Timing of Infant Food Introduction in Families With a History of Atopy , 2015, Clinical pediatrics.

[16]  D. Fleischer,et al.  The Complexities of Early Peanut Introduction for the Practicing Allergist. , 2016, The journal of allergy and clinical immunology. In practice.

[17]  G. Roberts,et al.  Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy , 2015, Pediatrics.

[18]  R. Kumar,et al.  The Prevalence, Severity, and Distribution of Childhood Food Allergy in the United States , 2011, Pediatrics.

[19]  D. Fleischer,et al.  Primary prevention of allergic disease through nutritional interventions. , 2013, The journal of allergy and clinical immunology. In practice.

[20]  P. Sasieni,et al.  Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. , 2008, The Journal of allergy and clinical immunology.

[21]  J. Godbold,et al.  US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. , 2010, The Journal of allergy and clinical immunology.

[22]  K. Allen,et al.  Optimal timing for solids introduction – why are the guidelines always changing? , 2013, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[23]  Anne-Louise Ponsonby,et al.  Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. , 2011, The Journal of allergy and clinical immunology.

[24]  G. Roberts,et al.  Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening study. , 2013, The Journal of allergy and clinical immunology.

[25]  A. Lowe,et al.  Natural history of peanut allergy and predictors of resolution in the first 4 years of life: A population-based assessment. , 2015, The Journal of allergy and clinical immunology.

[26]  B. Chipps,et al.  Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy , 2015, Pediatrics.

[27]  A. Burks,et al.  Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Timing of Introduction of Complementary Foods, and Hydrolyzed Formulas , 2008, Pediatrics.