Unmodified gold nanoparticles as a colorimetric probe for visual methamphetamine detection

ABSTRACT In recent years, in addition to the classic drugs, addiction to a series of new drug classes known as club drugs has increased significantly. Fast and low-cost bioassay for the detection of amphetamine-based drugs can be an effective strategy towards reducing their abuse. In this study, we designed a sensitive bioassay strategy using gold nanoparticles (GNPs) and the aptamers that possess high affinity toward methamphetamine (MA). It is suggested that the aptamer adopts different tertiary structures in the presence and/or absence of its specific target and GNPs can effectively differentiate between these two states by their characteristic surface plasmon resonance-based colour change. Visual detection of MA and 3,4-methylenedioxy-N-methylamphetamine (MDMA) in the low micromolar range is possible within minutes with the use of this method.

[1]  M. Nikkhah,et al.  Adsorption of DNA on colloidal Ag nanoparticles: effects of nanoparticle surface charge, base content and length of DNA. , 2014, Colloids and surfaces. B, Biointerfaces.

[2]  Chunhai Fan,et al.  A gold nanoparticle-based chronocoulometric DNA sensor for amplified detection of DNA , 2007, Nature Protocols.

[3]  Chad A Mirkin,et al.  Nanostructures in biodiagnostics. , 2005, Chemical reviews.

[4]  L. Rothberg,et al.  Kinetics and mechanism of single-stranded DNA adsorption onto citrate-stabilized gold nanoparticles in colloidal solution. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[5]  M. Deveaux,et al.  The Role of Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) to Test Blood and Urine Samples for the Toxicological Investigation of Drug-Facilitated Crimes , 2008, Therapeutic drug monitoring.

[6]  D. Patel,et al.  Adaptive recognition by nucleic acid aptamers. , 2000, Science.

[7]  Juewen Liu,et al.  Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparticles. , 2005, Angewandte Chemie.

[8]  R. de la Torre,et al.  Usefulness of saliva for measurement of 3,4-methylenedioxymethamphetamine and its metabolites: correlation with plasma drug concentrations and effect of salivary pH. , 2001, Clinical chemistry.

[9]  X. Q. Li,et al.  Simultaneous separation and confirmation of amphetamine and related drugs in equine plasma by non-aqueous capillary-electrophoresis-tandem mass spectrometry. , 2010, Drug testing and analysis.

[10]  Huixiang Li,et al.  Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Aurélie Bugey,et al.  Rapid analysis of benzodiazepines in whole blood by high-performance liquid chromatography: use of a monolithic column. , 2004, Journal of pharmaceutical and biomedical analysis.

[12]  J. Hillier,et al.  A study of the nucleation and growth processes in the synthesis of colloidal gold , 1951 .

[13]  A. Christophersen,et al.  Determination of benzodiazepines in human urine using solid-phase extraction and high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. , 2006, Journal of analytical toxicology.

[14]  Xiaofang Hu,et al.  Unmodified gold nanoparticles as a colorimetric probe for potassium DNA aptamers. , 2006, Chemical communications.

[15]  U. Krull,et al.  Localized surface plasmon resonance: nanostructures, bioassays and biosensing--a review. , 2011, Analytica chimica acta.

[16]  C. Mirkin,et al.  Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. , 2002, Science.

[17]  Paolo Bergese,et al.  Cavitand-grafted silicon microcantilevers as a universal probe for illicit and designer drugs in water. , 2014, Angewandte Chemie.

[18]  Stacy D. Brown,et al.  A validated SPME-GC-MS method for simultaneous quantification of club drugs in human urine. , 2007, Forensic science international.

[19]  Chunhai Fan,et al.  Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures. , 2008, Small.

[20]  R. TiwariNeha,et al.  Gold Nanoparticles for Colorimetric detection of hydrolysis of antibiotics by penicillin G acylase , 2010 .

[21]  Duncan Graham,et al.  Sequence-specific DNA detection using high-affinity LNA-functionalized gold nanoparticles. , 2007, Small.

[22]  Francesco Saverio Romolo,et al.  Toward street detection of amphetamines , 2013 .

[23]  J. Darius,et al.  Validated method for the therapeutic drug monitoring of flunitrazepam in human serum using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry with an ion trap detector. , 2000, Journal of chromatography. B, Biomedical sciences and applications.

[24]  C. Mirkin,et al.  Scanometric DNA array detection with nanoparticle probes. , 2000, Science.

[25]  L. Lechuga,et al.  LSPR-based nanobiosensors , 2009 .

[26]  Andreas Meisel,et al.  Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview , 2009, Molecular Neurobiology.

[27]  Dieter Söll,et al.  Cover Picture: Recoding the Genetic Code with Selenocysteine (Angew. Chem. Int. Ed. 1/2014) , 2014 .

[28]  Stacy D. Brown,et al.  Trends in bioanalytical methods for the determination and quantification of club drugs: 2000-2010. , 2011, Biomedical chromatography : BMC.

[29]  Mostafa A. El-Sayed,et al.  Why Gold Nanoparticles Are More Precious than Pretty Gold: Noble Metal Surface Plasmon Resonance and Its Enhancement of the Radiative and Nonradiative Properties of Nanocrystals of Different Shapes , 2006 .

[30]  A. Barzegari,et al.  Systematic Evolution of Ligands by Exponential Enrichment Selection of Specific Aptamer for Sensing of Methamphetamine , 2013 .

[31]  M. El-Sayed,et al.  Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. , 2006, Chemical Society reviews.

[32]  Jaleh Barar,et al.  Electrochemical impedance spectroscopic sensing of methamphetamine by a specific aptamer. , 2012, BioImpacts : BI.

[33]  D. Xing,et al.  Sensitive colorimetric detection of Listeria monocytogenes based on isothermal gene amplification and unmodified gold nanoparticles. , 2013, Methods.

[34]  C. Huang,et al.  Visual colorimetric detection of berberine hydrochloride with silver nanoparticles. , 2008, Journal of pharmaceutical and biomedical analysis.

[35]  D. Xing,et al.  Rapid colorimetric gene-sensing of food pathogenic bacteria using biomodification-free gold nanoparticle , 2013 .

[36]  J. Storhoff,et al.  A DNA-based method for rationally assembling nanoparticles into macroscopic materials , 1996, Nature.