Photothermal therapy method based on photoacoustic/ultrasonic dual-mode temperature measurement and regulation

Tumor photothermal therapy technology has received a lot of attention in recent years due to its non-invasive and targeted properties. However, how to ensure the safety and effectiveness of the photothermal treatment process poses new challenges to researchers. The field of photothermal therapy urgently needs a non-contact and accurate temperature detection method. In this paper, we have proposed a precise temperature detection technology based on photoacoustic and ultrasonic dual mode which can provide accurate and non-contact temperature measurement, and the temperature information of the light-induced ultrasound signals was fused and applied to temperature detection. To validate our method, temperatures of phantom was measured within the temperature range that simulates the heating process of photothermal therapy, and the calculated temperature measurement error was finally within 1 °C. In particular, it was also verified that the measurement accuracy of this method is 30% higher than that of single photoacoustic temperature detection. The results suggested that our method can be potentially used for temperature monitoring during photothermal therapy.