Childhood maltreatment, juvenile disorders and adult post-traumatic stress disorder: a prospective investigation

Background We examine prospectively the influence of two separate but potentially inter-related factors in the etiology of post-traumatic stress disorder (PTSD): childhood maltreatment as conferring a susceptibility to the PTSD response to adult trauma and juvenile disorders as precursors of adult PTSD. Method The Dunedin Multidisciplinary Health and Development Study (DMHDS) is a birth cohort (n = 1037) from the general population of New Zealand's South Island, with multiple assessments up to age 38 years. DSM-IV PTSD was assessed among participants exposed to trauma at ages 26–38. Complete data were available on 928 participants. Results Severe maltreatment in the first decade of life, experienced by 8.5% of the sample, was associated significantly with the risk of PTSD among those exposed to adult trauma [odds ratio (OR) 2.64, 95% confidence interval (CI) 1.16–6.01], compared to no maltreatment. Moderate maltreatment, experienced by 27.2%, was not associated significantly with that risk (OR 1.55, 95% CI 0.85–2.85). However, the two estimates did not differ significantly from one another. Juvenile disorders (ages 11–15), experienced by 35% of the sample, independent of childhood maltreatment, were associated significantly with the risk of PTSD response to adult trauma (OR 2.35, 95% CI 1.32–4.18). Conclusions Severe maltreatment is associated with risk of PTSD response to adult trauma, compared to no maltreatment, and juvenile disorders, independent of earlier maltreatment, are associated with that risk. The role of moderate maltreatment remains unresolved. Larger longitudinal studies are needed to assess the impact of moderate maltreatment, experienced by the majority of adult trauma victims with a history of maltreatment.

[1]  J. Troost,et al.  Influence of predispositions on post-traumatic stress disorder: does it vary by trauma severity? , 2012, Psychological Medicine.

[2]  J. Buxbaum,et al.  Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD , 2010, Psychopharmacology.

[3]  P. Ellis,et al.  Prospectively ascertained child maltreatment and its association with DSM-IV mental disorders in young adults. , 2010, Archives of general psychiatry.

[4]  S. Gilman,et al.  Race/ethnic differences in exposure to traumatic events, development of post-traumatic stress disorder, and treatment-seeking for post-traumatic stress disorder in the United States , 2010, Psychological Medicine.

[5]  R. Kessler,et al.  Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication II: associations with persistence of DSM-IV disorders. , 2010, Archives of general psychiatry.

[6]  Daniel L. Segal,et al.  Diagnostic Interview Schedule for DSM-IV (DIS-IV) , 2010 .

[7]  Kerry J Ressler,et al.  Risk and resilience: Genetic and environmental influences on development of the stress response , 2009, Depression and anxiety.

[8]  C. North,et al.  Toward validation of the diagnosis of posttraumatic stress disorder. , 2009, The American journal of psychiatry.

[9]  R. Yehuda,et al.  Risk Factors and the Adversity‐Stress Model , 2008 .

[10]  A. Caspi,et al.  The developmental mental-disorder histories of adults with posttraumatic stress disorder: a prospective longitudinal birth cohort study. , 2008, Journal of abnormal psychology.

[11]  N. Breslau,et al.  A second look at prior trauma and the posttraumatic stress disorder effects of subsequent trauma: a prospective epidemiological study. , 2008, Archives of general psychiatry.

[12]  Richie Poulton,et al.  Childhood maltreatment predicts adult inflammation in a life-course study , 2007, Proceedings of the National Academy of Sciences.

[13]  J. Anthony,et al.  Childhood antecedents of exposure to traumatic events and posttraumatic stress disorder. , 2007, The American journal of psychiatry.

[14]  N. Breslau,et al.  Intelligence and other predisposing factors in exposure to trauma and posttraumatic stress disorder: a follow-up study at age 17 years. , 2006, Archives of general psychiatry.

[15]  Richie Poulton,et al.  Early childhood factors associated with the development of post-traumatic stress disorder: results from a longitudinal birth cohort , 2006, Psychological Medicine.

[16]  J. Anthony,et al.  Trauma exposure and posttraumatic stress disorder: A study of youths in urban America , 2004, Journal of Urban Health.

[17]  Olga V. Demler,et al.  Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. , 2005, Archives of general psychiatry.

[18]  A. Caspi,et al.  Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. , 2003, Archives of general psychiatry.

[19]  D. Weiss,et al.  Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis. , 2003, Psychological bulletin.

[20]  N. Breslau.  Epidemiologic Studies of Trauma, Posttraumatic Stress Disorder, and other Psychiatric Disorders , 2002, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[21]  A. Caspi,et al.  Role of Genotype in the Cycle of Violence in Maltreated Children , 2002, Science.

[22]  J. Anthony,et al.  The uniqueness of the DSM definition of post-traumatic stress disorder: implications for research , 2002, Psychological Medicine.

[23]  S. Galea,et al.  Psychological sequelae of the September 11 terrorist attacks in New York City. , 2002, The New England journal of medicine.

[24]  F P Stafford,et al.  Event history calendars and question list surveys: a direct comparison of interviewing methods. , 2001, Public opinion quarterly.

[25]  N. Breslau,et al.  A second look at comorbidity in victims of trauma: the posttraumatic stress disorder–major depression connection , 2000, Biological Psychiatry.

[26]  C. Brewin,et al.  Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. , 2000, Journal of consulting and clinical psychology.

[27]  C. Widom.  Posttraumatic stress disorder in abused and neglected children grown up. , 1999, The American journal of psychiatry.

[28]  R. Kessler,et al.  Previous exposure to trauma and PTSD effects of subsequent trauma: results from the Detroit Area Survey of Trauma. , 1999, The American journal of psychiatry.

[29]  R. Post,et al.  Sensitization and kindling phenomena in mood, anxiety, and obsessive–compulsive disorders: the role of serotonergic mechanisms in illness progression , 1998, Biological Psychiatry.

[30]  R. Kessler,et al.  Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma. , 1998, Archives of general psychiatry.

[31]  R. Kessler,et al.  Risk factors for DSM-III-R posttraumatic stress disorder: findings from the National Comorbidity Survey. , 1998, American journal of epidemiology.

[32]  R. Kessler,et al.  Posttraumatic stress disorder in the National Comorbidity Survey. , 1995, Archives of general psychiatry.

[33]  R. Yehuda,et al.  Effect of previous trauma on acute plasma cortisol level following rape. , 1995, The American journal of psychiatry.

[34]  S. Southwick,et al.  Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. , 1993, The American journal of psychiatry.

[35]  R. Post,et al.  Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. , 1992, The American journal of psychiatry.

[36]  N. Breslau,et al.  Traumatic events and posttraumatic stress disorder in an urban population of young adults. , 1991, Archives of general psychiatry.

[37]  Phil A. Silva,et al.  DSM-III disorders in a large sample of adolescents. , 1990, Journal of the American Academy of Child and Adolescent Psychiatry.

[38]  T. Moffitt,et al.  Neuropsychological correlates of psychopathology in an unselected cohort of young adolescents. , 1989, Journal of abnormal psychology.

[39]  Phil A. Silva,et al.  DSM-III disorders in preadolescent children. Prevalence in a large sample from the general population. , 1987, Archives of general psychiatry.

[40]  D. Rubin,et al.  The central role of the propensity score in observational studies for causal effects , 1983 .