PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
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Chunxiang Zhang | D. Fulton | N. Weintraub | Chaodong Wu | T. Fukai | Y. Huo | Lei Huang | ZhenXie Han | V. Sudhahar | Qiuhua Yang | Yiming Xu | Yong Wang | Yaqi Zhou | Zhiping Liu | Lina Wang | Jiean Xu | Yapeng Cao | Mei Hong | Tao Wang | Qian Ma | Min Zhang | Xianqiu Zeng | Yuqing Huo | Varadarajan Sudhahar
[1] C. Weber,et al. CANTOS Trial Validates the Inflammatory Pathogenesis of Atherosclerosis: Setting the Stage for a New Chapter in Therapeutic Targeting. , 2017, Circulation Research.
[2] H. Jo,et al. Mechanical Activation of Hypoxia-Inducible Factor 1 alpha Drives Endothelial Dysfunction at Atheroprone Sites , 2022 .
[3] Lois E. H. Smith,et al. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis , 2017, Nature Communications.
[4] P. Libby,et al. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease , 2017, The New England journal of medicine.
[5] C. Weber,et al. Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis , 2017, EMBO molecular medicine.
[6] N. Prabhakar,et al. HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium , 2017, eLife.
[7] Miao Zhang,et al. AMP-activated protein kinase α1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation , 2017, The Journal of Biological Chemistry.
[8] S. Wingert,et al. AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis , 2017, Circulation research.
[9] Sheng-nan Wu,et al. Ablation of Adenosine Monophosphate-Activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo. , 2016, Circulation research.
[10] M. Schwartz,et al. Endothelial fluid shear stress sensing in vascular health and disease. , 2016, The Journal of clinical investigation.
[11] L. O’Neill,et al. Metabolic reprogramming in macrophages and dendritic cells in innate immunity , 2015, Cell Research.
[12] P. Carmeliet,et al. Fatty acid carbon is essential for dNTP synthesis in endothelial cells , 2015, Nature.
[13] N. Ruderman,et al. Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes , 2015, PloS one.
[14] J. Dunn,et al. Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. , 2014, The Journal of clinical investigation.
[15] Yunchao Su,et al. Endothelial PFKFB3 Plays a Critical Role in Angiogenesis , 2014, Arteriosclerosis, thrombosis, and vascular biology.
[16] Jessilyn Dunn,et al. Fluid Mechanics, Arterial Disease, and Gene Expression. , 2014, Annual review of fluid mechanics.
[17] P. Pinton,et al. Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes , 2013, Nature Protocols.
[18] C. Weyand,et al. Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells , 2013, The Journal of experimental medicine.
[19] P. Carmeliet,et al. Role of PFKFB3-Driven Glycolysis in Vessel Sprouting , 2013, Cell.
[20] A. Shaywitz,et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. , 2013, Molecular cell.
[21] Takla Griss,et al. AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. , 2013, Cell metabolism.
[22] C. Apovian,et al. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue[S] , 2012, Journal of Lipid Research.
[23] G. Semenza,et al. Hypoxia-Inducible Factors in Physiology and Medicine , 2012, Cell.
[24] R. Shaw,et al. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism , 2011, Nature Cell Biology.
[25] John M Tarbell,et al. The role of mitosis in LDL transport through cultured endothelial cell monolayers. , 2011, American journal of physiology. Heart and circulatory physiology.
[26] H. Choi,et al. Reduction of AMP-Activated Protein Kinase &agr;2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo , 2010, Circulation.
[27] David Harrison,et al. Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. , 2009, American journal of physiology. Heart and circulatory physiology.
[28] B. Fisslthaler,et al. Activation and signaling by the AMP-activated protein kinase in endothelial cells. , 2009, Circulation research.
[29] Chunxiang Zhang,et al. Core2 1-6-N-Glucosaminyltransferase-I Deficiency Protects Injured Arteries From Neointima Formation in ApoE-Deficient Mice , 2009, Arteriosclerosis, thrombosis, and vascular biology.
[30] M. Tsai,et al. AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633 , 2009, Circulation research.
[31] Shu Chien,et al. Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosis , 2009, Annals of medicine.
[32] Huan Wang,et al. P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6Chi Monocytes and a Major Determinant for Ly-6Chi Monocyte Recruitment to Sites of Atherosclerosis in Mice , 2008, Circulation.
[33] Qingbo Xu,et al. Rapid Endothelial Turnover in Atherosclerosis-Prone Areas Coincides With Stem Cell Repair in Apolipoprotein E–Deficient Mice , 2008, Circulation.
[34] P. Quax,et al. Vaccination Against VEGFR2 Attenuates Initiation and Progression of Atherosclerosis , 2007 .
[35] S. Chien,et al. Regulation of Endothelial Cell Cycle by Laminar Versus Oscillatory Flow: Distinct Modes of Interactions of AMP-Activated Protein Kinase and Akt Pathways , 2007, Circulation research.
[36] B. Kemp,et al. AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling , 2007, Circulation research.
[37] E. Araki,et al. AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer , 2006, The Journal of physiology.
[38] T. Garland,et al. AMP-Activated Protein Kinase Is Involved in Endothelial NO Synthase Activation in Response to Shear Stress , 2006, Arteriosclerosis, thrombosis, and vascular biology.
[39] S. Moncada,et al. Mitochondria as signaling organelles in the vascular endothelium. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[40] C. Stoeckert,et al. Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[41] Minyoung Lee,et al. AMP-activated Protein Kinase Activity Is Critical for Hypoxia-inducible Factor-1 Transcriptional Activity and Its Target Gene Expression under Hypoxic Conditions in DU145 Cells* , 2003, Journal of Biological Chemistry.
[42] David Zurakowski,et al. Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[43] P. Libby. Inflammation in atherosclerosis , 2002, Nature.
[44] D. Hardie,et al. AMP‐activated protein kinase: the energy charge hypothesis revisited , 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.
[45] N. Ruderman,et al. Acute Regulation of Fatty Acid Oxidation and AMP-Activated Protein Kinase in Human Umbilical Vein Endothelial Cells , 2001, Circulation research.
[46] D. Power,et al. Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase* , 2001, The Journal of Biological Chemistry.
[47] Christopher K. Glass,et al. Atherosclerosis The Road Ahead , 2001, Cell.
[48] O. Tricot,et al. Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques. , 2000, Circulation.
[49] R. Ross,et al. Atherosclerosis is an Inflammatory Disease , 1998 .
[50] C. Kahn,et al. Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus , 1996, Trends in Endocrinology & Metabolism.
[51] B. Kemp,et al. Mammalian AMP-activated Protein Kinase Subfamily (*) , 1996, The Journal of Biological Chemistry.
[52] M. Reidy,et al. Mouse model of arterial injury. , 1993, Circulation research.
[53] D. Blankenhorn,et al. Inherited Depression of Arterial Lipoamide Dehydrogenase Activity Associated with Susceptibility to Atherosclerosis in Pigeons , 1975, Circulation research.
[54] R. Ross,et al. Atherosclerosis and the Arterial Smooth Muscle Cell , 1973 .
[55] J. Frick,et al. Glucose degradation in normal and atherosclerotic aortic intima-media. , 1972, Atherosclerosis.
[56] H. Lofland,et al. Studies on the atherosclerotic pigeon. , 1962, JAMA.
[57] A. Zeiher,et al. Laminar Shear Stress Inhibits Endothelial Cell Metabolism via Krüppel-Like Factor 2 – Mediated Repression of 6-Phosphofructo-2-Kinase / Fructose-2 , 6-Biphosphatase-3 , 2014 .
[58] S. Chien,et al. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. , 2011, Physiological reviews.
[59] Louise Lantier,et al. AMPK: Lessons from transgenic and knockout animals. , 2009, Frontiers in bioscience.
[60] D. Hardie,et al. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. , 2005, Cell metabolism.
[61] R. Ross,et al. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. , 1973, Science.