PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis

[1]  C. Weber,et al.  CANTOS Trial Validates the Inflammatory Pathogenesis of Atherosclerosis: Setting the Stage for a New Chapter in Therapeutic Targeting. , 2017, Circulation Research.

[2]  H. Jo,et al.  Mechanical Activation of Hypoxia-Inducible Factor 1 alpha Drives Endothelial Dysfunction at Atheroprone Sites , 2022 .

[3]  Lois E. H. Smith,et al.  Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis , 2017, Nature Communications.

[4]  P. Libby,et al.  Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease , 2017, The New England journal of medicine.

[5]  C. Weber,et al.  Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis , 2017, EMBO molecular medicine.

[6]  N. Prabhakar,et al.  HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium , 2017, eLife.

[7]  Miao Zhang,et al.  AMP-activated protein kinase α1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation , 2017, The Journal of Biological Chemistry.

[8]  S. Wingert,et al.  AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis , 2017, Circulation research.

[9]  Sheng-nan Wu,et al.  Ablation of Adenosine Monophosphate-Activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo. , 2016, Circulation research.

[10]  M. Schwartz,et al.  Endothelial fluid shear stress sensing in vascular health and disease. , 2016, The Journal of clinical investigation.

[11]  L. O’Neill,et al.  Metabolic reprogramming in macrophages and dendritic cells in innate immunity , 2015, Cell Research.

[12]  P. Carmeliet,et al.  Fatty acid carbon is essential for dNTP synthesis in endothelial cells , 2015, Nature.

[13]  N. Ruderman,et al.  Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes , 2015, PloS one.

[14]  J. Dunn,et al.  Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. , 2014, The Journal of clinical investigation.

[15]  Yunchao Su,et al.  Endothelial PFKFB3 Plays a Critical Role in Angiogenesis , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[16]  Jessilyn Dunn,et al.  Fluid Mechanics, Arterial Disease, and Gene Expression. , 2014, Annual review of fluid mechanics.

[17]  P. Pinton,et al.  Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes , 2013, Nature Protocols.

[18]  C. Weyand,et al.  Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells , 2013, The Journal of experimental medicine.

[19]  P. Carmeliet,et al.  Role of PFKFB3-Driven Glycolysis in Vessel Sprouting , 2013, Cell.

[20]  A. Shaywitz,et al.  AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. , 2013, Molecular cell.

[21]  Takla Griss,et al.  AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. , 2013, Cell metabolism.

[22]  C. Apovian,et al.  Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue[S] , 2012, Journal of Lipid Research.

[23]  G. Semenza,et al.  Hypoxia-Inducible Factors in Physiology and Medicine , 2012, Cell.

[24]  R. Shaw,et al.  The AMPK signalling pathway coordinates cell growth, autophagy and metabolism , 2011, Nature Cell Biology.

[25]  John M Tarbell,et al.  The role of mitosis in LDL transport through cultured endothelial cell monolayers. , 2011, American journal of physiology. Heart and circulatory physiology.

[26]  H. Choi,et al.  Reduction of AMP-Activated Protein Kinase &agr;2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo , 2010, Circulation.

[27]  David Harrison,et al.  Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. , 2009, American journal of physiology. Heart and circulatory physiology.

[28]  B. Fisslthaler,et al.  Activation and signaling by the AMP-activated protein kinase in endothelial cells. , 2009, Circulation research.

[29]  Chunxiang Zhang,et al.  Core2 1-6-N-Glucosaminyltransferase-I Deficiency Protects Injured Arteries From Neointima Formation in ApoE-Deficient Mice , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[30]  M. Tsai,et al.  AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633 , 2009, Circulation research.

[31]  Shu Chien,et al.  Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosis , 2009, Annals of medicine.

[32]  Huan Wang,et al.  P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6Chi Monocytes and a Major Determinant for Ly-6Chi Monocyte Recruitment to Sites of Atherosclerosis in Mice , 2008, Circulation.

[33]  Qingbo Xu,et al.  Rapid Endothelial Turnover in Atherosclerosis-Prone Areas Coincides With Stem Cell Repair in Apolipoprotein E–Deficient Mice , 2008, Circulation.

[34]  P. Quax,et al.  Vaccination Against VEGFR2 Attenuates Initiation and Progression of Atherosclerosis , 2007 .

[35]  S. Chien,et al.  Regulation of Endothelial Cell Cycle by Laminar Versus Oscillatory Flow: Distinct Modes of Interactions of AMP-Activated Protein Kinase and Akt Pathways , 2007, Circulation research.

[36]  B. Kemp,et al.  AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling , 2007, Circulation research.

[37]  E. Araki,et al.  AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer , 2006, The Journal of physiology.

[38]  T. Garland,et al.  AMP-Activated Protein Kinase Is Involved in Endothelial NO Synthase Activation in Response to Shear Stress , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[39]  S. Moncada,et al.  Mitochondria as signaling organelles in the vascular endothelium. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[40]  C. Stoeckert,et al.  Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Minyoung Lee,et al.  AMP-activated Protein Kinase Activity Is Critical for Hypoxia-inducible Factor-1 Transcriptional Activity and Its Target Gene Expression under Hypoxic Conditions in DU145 Cells* , 2003, Journal of Biological Chemistry.

[42]  David Zurakowski,et al.  Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  P. Libby Inflammation in atherosclerosis , 2002, Nature.

[44]  D. Hardie,et al.  AMP‐activated protein kinase: the energy charge hypothesis revisited , 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

[45]  N. Ruderman,et al.  Acute Regulation of Fatty Acid Oxidation and AMP-Activated Protein Kinase in Human Umbilical Vein Endothelial Cells , 2001, Circulation research.

[46]  D. Power,et al.  Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase* , 2001, The Journal of Biological Chemistry.

[47]  Christopher K. Glass,et al.  Atherosclerosis The Road Ahead , 2001, Cell.

[48]  O. Tricot,et al.  Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques. , 2000, Circulation.

[49]  R. Ross,et al.  Atherosclerosis is an Inflammatory Disease , 1998 .

[50]  C. Kahn,et al.  Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus , 1996, Trends in Endocrinology & Metabolism.

[51]  B. Kemp,et al.  Mammalian AMP-activated Protein Kinase Subfamily (*) , 1996, The Journal of Biological Chemistry.

[52]  M. Reidy,et al.  Mouse model of arterial injury. , 1993, Circulation research.

[53]  D. Blankenhorn,et al.  Inherited Depression of Arterial Lipoamide Dehydrogenase Activity Associated with Susceptibility to Atherosclerosis in Pigeons , 1975, Circulation research.

[54]  R. Ross,et al.  Atherosclerosis and the Arterial Smooth Muscle Cell , 1973 .

[55]  J. Frick,et al.  Glucose degradation in normal and atherosclerotic aortic intima-media. , 1972, Atherosclerosis.

[56]  H. Lofland,et al.  Studies on the atherosclerotic pigeon. , 1962, JAMA.

[57]  A. Zeiher,et al.  Laminar Shear Stress Inhibits Endothelial Cell Metabolism via Krüppel-Like Factor 2 – Mediated Repression of 6-Phosphofructo-2-Kinase / Fructose-2 , 6-Biphosphatase-3 , 2014 .

[58]  S. Chien,et al.  Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. , 2011, Physiological reviews.

[59]  Louise Lantier,et al.  AMPK: Lessons from transgenic and knockout animals. , 2009, Frontiers in bioscience.

[60]  D. Hardie,et al.  AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. , 2005, Cell metabolism.

[61]  R. Ross,et al.  Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. , 1973, Science.