Lasers and the surgeon.

The evolution of laser technology in medicine has progressed rapidly over the past 25 years, and these devices are widely used in surgical treatment today. Three different types of lasers are predominantly used: the carbon dioxide, argon ion, and neodymium-YAG instruments. Each operates on similar principles but because of the different wavelengths of light emitted, their applications differ. However, by and large, all of them utilize thermal energy generated by light and tissue interactions. Recently, the combination of an argon ion and a dye laser used with photosensitizing drugs has shown promise in the treatment of cancers, and this represents a nonthermal application of laser technology. In order to use lasers effectively, a knowledge of the specific laser and tissue properties is essential. In the future, lasers will be used not only as thermal scalpels but also as instruments than can provide a very precise delivery of energy to parts of the body that are otherwise inaccessible without operation. The use of photodynamic therapy will provide a mechanism of selectively destroying tumors while leaving normal tissues intact.

[1]  M. Hetzel,et al.  Laser therapy in 100 tracheobronchial tumours. , 1985, Thorax.

[2]  C. Gomer,et al.  Comparison of mutagenicity and induction of sister chromatid exchange in Chinese hamster cells exposed to hematoporphyrin derivative photoradiation, ionizing radiation, or ultraviolet radiation. , 1983, Cancer research.

[3]  H. Kato,et al.  Photodynamic therapy with hematoporphyrin derivative in cancer of the upper gastrointestinal tract. , 1985, Seminars in surgical oncology.

[4]  S. Joffe,et al.  Effects of Nd: YAG laser photoradiation on intra‐abdominal tissues: A histological study of tissue damage versus power density applied , 1986, Lasers in surgery and medicine.

[5]  T. Dougherty,et al.  Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue. , 1979, Cancer research.

[6]  Lasers in bronchology. , 1983, Otolaryngologic clinics of North America.

[7]  C. Ell,et al.  Combined therapy of malignant stenoses of the upper gastrointestinal tract by means of laser beam and bougienage. , 1985, Endoscopy.

[8]  R. Deterling,et al.  STUDIES OF THE SURGICAL APPLICATIONS OF LASER (LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION). , 1963, Surgical forum.

[9]  P. Cotton,et al.  Randomised trial of endoscopic argon laser photocoagulation in bleeding peptic ulcers. , 1981, Gut.

[10]  U. Nseyo,et al.  Experimental photodynamic treatment of canine bladder. , 1985, The Journal of urology.

[11]  D. Nicol,et al.  Amino-Acid Sequence of Human Insulin , 1960, Nature.

[12]  M. Gray,et al.  Hematoporphyrin derivative for detection and management of cancer , 1967, Cancer.

[13]  A. Ketcham,et al.  THE EFFECT OF NEODYMIUM LASER RADIATION ON TWO EXPERIMENTAL MALIGNANT TUMOR SYSTEMS. , 1965, Surgery, gynecology & obstetrics.

[14]  T. Dougherty,et al.  Intra-abdominal applications of hematoporphyrin photoradiation therapy. , 1983, Advances in experimental medicine and biology.

[15]  M. Berns,et al.  Potentiation of laser photoradiation therapy by chemotherapy. , 1985, Current surgery.

[16]  W S Grundfest,et al.  Pulsed ultraviolet lasers and the potential for safe laser angioplasty. , 1985, American journal of surgery.

[17]  T J Dougherty,et al.  Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light. , 1975, Journal of the National Cancer Institute.

[18]  T J Dougherty,et al.  Fluorescence bronchoscopy for detection of lung cancer. , 1979, Chest.

[19]  J. Paris,et al.  Villous adenomas of the rectum. Results of endoscopic treatment with argon and Nd:YAG lasers. , 1985, Gastroenterology.

[20]  J. Kosek,et al.  Histology of port wine stains following argon laser treatment. , 1979, British journal of plastic surgery.

[21]  J. Paris,et al.  Villous adenomas of the rectum , 1985 .

[22]  T. Northfield,et al.  CONTROLLED TRIAL OF Nd-YAG LASER PHOTOCOAGULATION IN BLEEDING PEPTIC ULCERS , 1986, The Lancet.

[23]  P. Rutgeerts,et al.  Controlled trial of YAG laser treatment of upper digestive hemorrhage. , 1982, Gastroenterology.

[24]  M. Sivak,et al.  Endoscopic Nd:YAG laser therapy as palliative treatment for advanced adenocarcinoma of the gastric cardia. , 1984, Gastroenterology.

[25]  N. Krasner,et al.  Advances in gastrointestinal endoscopy and laser therapy; the way ahead. , 1985, Scandinavian journal of gastroenterology. Supplement.

[26]  M. Sivak,et al.  Endoscopic Nd:YAG laser therapy as palliation for esophagogastric cancer. Parameters affecting initial outcome. , 1985, Gastroenterology.

[27]  T J Dougherty,et al.  Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor. , 1976, Cancer research.

[28]  S. Cavaliere,et al.  Principles for safety in application of neodymium-YAG laser in bronchology. , 1984, Chest.

[29]  J E Kaufman,et al.  Photoradiation therapy for the treatment of malignant tumors. , 1978, Cancer research.

[30]  E. Land,et al.  Porphyrin localization and treatment of tumors , 1985, British Journal of Cancer.

[31]  J. V. von Fraunhofer,et al.  Effects of thermal knives on wound healing. , 1985, Obstetrics and gynecology.

[32]  W. Grundfest,et al.  Delineation of Peripheral and Coronary Detail by Intraoperative Angioscopy , 1985, Annals of surgery.

[33]  M. Berns,et al.  Laser photoradiation therapy of cancer: An update of the experience at the university of California, Irvine , 1984, Lasers in surgery and medicine.

[34]  A. M. Olsen,et al.  The use of a derivative of hematoporphyrin in tumor detection. , 1961 .

[35]  P Kiefhaber,et al.  Endoscopical control of massive gastrointestinal hemorrhage by irradiation with a high-power Neodymium-Yag laser. , 1977, Progress in surgery.

[36]  J. H. Kinsey,et al.  Treatment of transitional cell carcinoma of the bladder with hematoporphyrin derivative phototherapy. , 1983, The Journal of urology.

[37]  T. Maiman Stimulated Optical Radiation in Ruby , 1960, Nature.

[38]  R. S. Mitchell,et al.  Salvage of an ischemic limb by laser angioplasty: Description of a New Technique , 1984, Clinical cardiology.

[39]  R. Orda,et al.  Partial distal pancreatectomy with a hand-held CO2 laser. An experimental study. , 1980, Archives of surgery.