Assessing the potential of pre-exposure vaccination and chemoprophylaxis in the control of lymphatic filariasis

Abstract An epidemiological model to assess the potential impact of pre-exposure vaccines and other intervention strategies on lymphatic filariasis is proposed and investigated. The threshold parameter of the model is computed and rigorously analysed. Results from model analysis suggests that vaccination at birth and pre-exposure vaccination will aid in reducing lymphatic filariasis disease burden. However, results further suggest that chemoprophylaxis or mosquito spraying alone may be able to keep lymphatic filariasis infections in check. Numerical simulations also show that treatment alone will not be able control the spread of lymphatic filariasis. Furthermore, results from numerical simulations suggest that treatment for the sick in addition to chemoprophylaxis for the exposed may be able to effectively control the spread of lymphatic filariasis.

[1]  G. A. Ngwa,et al.  A mathematical model for endemic malaria with variable human and mosquito populations , 2000 .

[2]  S. Babayan,et al.  Filarial Parasites Develop Faster and Reproduce Earlier in Response to Host Immune Effectors That Determine Filarial Life Expectancy , 2010, PLoS biology.

[3]  Subramanian Swaminathan,et al.  Mathematical models for lymphatic filariasis transmission and control: Challenges and prospects , 2008, Parasites & Vectors.

[4]  J. Tan.  The Elimination of Lymphatic Filariasis: A Strategy for Poverty Alleviation and Sustainable Development – Perspectives from the Philippines , 2003 .

[5]  W. Melrose.  Lymphatic filariasis: new insights into an old disease. , 2002, International journal for parasitology.

[6]  H M Yang,et al.  Malaria transmission model for different levels of acquired immunity and temperature-dependent parameters (vector). , 2000, Revista de saude publica.

[7]  G. A. Ngwa.  Modelling the dynamics of endemic malaria in growing populations , 2004 .

[8]  Joan L. Aron,et al.  Mathematical modelling of immunity to malaria , 1988 .

[9]  H. Gelderblom.  Lymphatic filariasis: the disease and its control. Fifth report of the WHO Expert Committee on Filariasis. , 1992, World Health Organization technical report series.

[10]  Deterministic Malaria Transmission Model with Acquired Immunity , 2009 .

[11]  H M Yang,et al.  Assessing the effects of global warming and local social and economic conditions on the malaria transmission. , 2000, Revista de saude publica.

[12]  S. Dadzie,et al.  Lymphatic filariasis in Ghana: entomological investigation of transmission dynamics and intensity in communities served by irrigation systems in the Upper East Region of Ghana , 2001, Tropical medicine & international health : TM & IH.

[13]  J. Norões,et al.  Pathogenesis of lymphatic disease in bancroftian filariasis: a clinical perspective. , 2000, Parasitology today.

[14]  Gary J Weil,et al.  Diagnostic tools for filariasis elimination programs. , 2007, Trends in parasitology.

[15]  Joan L. Aron,et al.  Mathematical modeling of immunity to malaria , 1989 .

[16]  Hadi Dowlatabadi,et al.  Sensitivity and Uncertainty Analysis of Complex Models of Disease Transmission: an HIV Model, as an Example , 1994 .

[17]  E. Michael,et al.  Global mapping of lymphatic filariasis. , 1997, Parasitology today.

[18]  E. Sartono,et al.  Long-term follow-up of treatment with diethylcarbamazine on anti-filarial IgG4: dosage, compliance, and differential patterns in adults and children. , 2003, The American journal of tropical medicine and hygiene.

[19]  P. D. Raadt,et al.  The burden of tropical diseases , 1993, The Medical journal of Australia.

[20]  J. Watmough,et al.  Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. , 2002, Mathematical biosciences.

[21]  Alan Brooks,et al.  Modeling the public health impact of malaria vaccines for developers and policymakers , 2013, BMC Infectious Diseases.

[22]  Senelani Dorothy Hove-Musekwa,et al.  Determining Effective Spraying Periods to Control Malaria via Indoor Residual Spraying in Sub-Saharan Africa , 2008, Adv. Decis. Sci..

[23]  NAKUL CHITNIS,et al.  Bifurcation Analysis of a Mathematical Model for Malaria Transmission , 2006, SIAM J. Appl. Math..

[24]  B. Grenfell,et al.  Re-assessing the global prevalence and distribution of lymphatic filariasis , 1996, Parasitology.

[25]  M. Halloran,et al.  A family study of lymphedema of the leg in a lymphatic filariasis-endemic area. , 2004, The American journal of tropical medicine and hygiene.

[26]  E. Ottesen,et al.  Lymphatic filariasis infection and disease: Control strategies , 1995 .

[27]  Edwin Michael,et al.  Modelling Co-Infection with Malaria and Lymphatic Filariasis , 2013, PLoS Comput. Biol..