Huntington's disease

Huntington's disease (HD) is an autosomal dominant disorder of midlife onset, characterized by progressive involuntary choreiform movements, psychologic change, and dementia. In 1980, funded by the NINCDS, we established a center for the study of HD. This report presents a summary of our contributions to the investigation of this tragic disorder and a review of current ideas about the disease.

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[62]  Joseph B. Martin,et al.  Effects of lesions on somatostatin-like immunoreactivity in the rat striatum , 1983, Brain Research.

[63]  Joseph B. Martin,et al.  Somatostatin is increased in the basal ganglia in Huntington disease , 1983, Annals of neurology.

[64]  C. Nemeroff,et al.  Regional brain concentrations of neuropeptides in Huntington's chorea and schizophrenia. , 1983, Science.

[65]  S. Folstein,et al.  Conduct disorder and affective disorder among the offspring of patients with Huntington's Disease , 1983, Psychological Medicine.

[66]  S. Folstein,et al.  The association of affective disorder with Huntington's Disease in a case series and in families , 1983, Psychological Medicine.

[67]  P. Wolf,et al.  MATERNAL TRANSMISSION IN HUNTINGTON'S DISEASE , 1983, The Lancet.

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[69]  Joseph B. Martin,et al.  Somatostatin is increased in the nucleus accumbens in Huntington's disease , 1984, Neurology.

[70]  R. Myers,et al.  Potential impact of a predictive test on the gene frequency of Huntington disease. , 1984, American journal of medical genetics.

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[73]  D. Landis,et al.  Huntington's disease is accompanied by changes in the distribution of somatostatin-containing neuronal processes , 1985, Brain Research.