Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus.

[1]  H. Klinger,et al.  Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B. , 1997, Human molecular genetics.

[2]  C. Croce,et al.  The FHIT Gene at 3p14.2 Is Abnormal in Lung Cancer , 1996, Cell.

[3]  T. Iwama,et al.  DNA alterations in cells from hereditary non-polyposis colorectal cancer patients. , 1994, Oncogene.

[4]  D. Shibata,et al.  c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung. , 1994, The American journal of pathology.

[5]  Y. Takeshima,et al.  p53 mutations in lung cancers from non-smoking atomic-bomb survivors , 1993, The Lancet.

[6]  A. Marchetti,et al.  p53 alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes. , 1993, Cancer research.

[7]  G. Wahl,et al.  Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles , 1992, Cell.

[8]  Thea D. Tlsty,et al.  Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53 , 1992, Cell.

[9]  R. Ueda,et al.  p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking. , 1992, Cancer research.

[10]  T. Pechacek,et al.  Smoking-attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States? , 1991, Journal of the National Cancer Institute.

[11]  E. Fontham.  Lung cancer in nonsmoking women , 1991 .

[12]  J. Minna,et al.  p53: a frequent target for genetic abnormalities in lung cancer. , 1989, Science.

[13]  S. Rodenhuis,et al.  Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. , 1988, Cancer research.

[14]  C. Mountain,et al.  A new international staging system for lung cancer. , 1987, Chest.

[15]  The World Health Organization. Histological typing of lung tumours. , 1982, Neoplasma.

[16]  N. Blin,et al.  A general method for isolation of high molecular weight DNA from eukaryotes. , 1976, Nucleic acids research.