Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activity.
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Aurélien Grosdidier | Olivier Michielin | Vincent Zoete | Laura Guasch | Miquel Mulero | Gerard Pujadas | Santiago Garcia-Vallvé | Esther Sala | Justyna Iwaszkiewicz | V. Zoete | Cristina Valls | M. Mulero | S. Garcia-Vallvé | G. Pujadas | O. Michielin | M. Salvadó | L. Guasch | A. Grosdidier | Cinta Bladé | Maria-Josepa Salvadó | Meritxell Ceballos | Cristina Valls | Justyna Iwaszkiewicz | Esther Sala | C. Bladé | M. Ceballos | S. García-Vallvé
[1] V. Zoete,et al. Identification of Human IKK-2 Inhibitors of Natural Origin (Part I): Modeling of the IKK-2 Kinase Domain, Virtual Screening and Activity Assays , 2011, PloS one.
[2] Sung-Hoon Kim,et al. Inhibitory Effects of Paeonia suffruticosa on Allergic Reactions by Inhibiting the NF-kappaB/IkappaB-alpha Signaling Pathway and Phosphorylation of ERK in an Animal Model and Human Mast Cells , 2010, Bioscience, biotechnology, and biochemistry.
[3] W. Ko,et al. Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia. , 2010, European journal of pharmacology.
[4] A. Tiwari,et al. Gastroprotective flavonoid constituents from Oroxylum indicum Vent. , 2010, Bioorganic & medicinal chemistry letters.
[5] I. Lemieux,et al. Obesity, Inflammation, and Cardiovascular Risk , 2010, Clinical pharmacology and therapeutics.
[6] M. Číž,et al. Serotonin and its 5-HT(2) receptor agonist DOI hydrochloride inhibit the oxidative burst in total leukocytes but not in isolated neutrophils. , 2010, Life sciences.
[7] X. Yao,et al. Quassidines A-D, bis-beta-carboline alkaloids from the stems of Picrasma quassioides. , 2010, Journal of Natural Products.
[8] A. Abena,et al. Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts. , 2010, Journal of ethnopharmacology.
[9] I. Matsui‐yuasa,et al. Anti‐obesity effect of blumea balsamifera extract in 3T3‐L1 preadipocytes and adipocytes , 2010, The American journal of Chinese medicine.
[10] B. Shim,et al. Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. , 2009, Journal of ethnopharmacology.
[11] J. Vita,et al. Grapes and cardiovascular disease. , 2009, The Journal of nutrition.
[12] P. Tansakul,et al. Anti-inflammatory mechanism of Kaempferia parviflora in murine macrophage cells (RAW 264.7) and in experimental animals. , 2009, Journal of ethnopharmacology.
[13] B. Fiebich,et al. Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other pro-inflammatory mediators. , 2009, Journal of ethnopharmacology.
[14] J. M. Mateo-Sanz,et al. 3D-QSAR Study of Pyridine Derivates as IKK-2 Inhibitors , 2009 .
[15] H. Khan,et al. Anti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn , 2009, Journal of enzyme inhibition and medicinal chemistry.
[16] G. Pujadas,et al. In vivo, in vitro, and in silico studies of Cu/Zn-superoxide dismutase regulation by molecules in grape seed procyanidin extract. , 2009, Journal of agricultural and food chemistry.
[17] M. Karst,et al. The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function , 2009, Pharmacology.
[18] D. Kaul,et al. Inhibitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease , 2009, Platelets.
[19] G. Hotamisligil,et al. Nutrient sensing and inflammation in metabolic diseases , 2008, Nature Reviews Immunology.
[20] D. Hou,et al. Expression Profiling of Genes Targeted by Bilberry (Vaccinium myrtillus) in Macrophages Through DNA Microarray , 2008, Nutrition and cancer.
[21] H. Kikuzaki,et al. Phenolic glycosides from Kaempferia parviflora. , 2008, Phytochemistry.
[22] Olivier Sperandio,et al. FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects , 2008, BMC Bioinformatics.
[23] Yu Lin,et al. Comparison with Various Parts of Broussonetia papyrifera as to the Antinociceptive and Anti-Inflammatory Activities in Rodents , 2008, Bioscience, biotechnology, and biochemistry.
[24] N. Menković,et al. Anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract. , 2008, Journal of agricultural and food chemistry.
[25] Prabhjot Singh,et al. Piper longum Linn. Extract inhibits TNF-α-induced expression of cell adhesion molecules by inhibiting NF-κB activation and microsomal lipid peroxidation , 2008 .
[26] J. Schmid,et al. IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB. , 2008, Cytokine & growth factor reviews.
[27] Jae Yeon Kim,et al. In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. , 2008, Bioorganic & medicinal chemistry letters.
[28] T. Hwang,et al. Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae. , 2008, Journal of natural products.
[29] M. Déciga-Campos,et al. Antinociceptive and anti-inflammatory effects of compounds isolated from Scaphyglottis livida and Maxillaria densa. , 2007, Journal of ethnopharmacology.
[30] J. Seckl,et al. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target. , 2007, Drug discovery today.
[31] V. Uylaşer,et al. Effect of brining on biological activity of leaves of Vitis vinifera L. (Cv. Sultani Cekirdeksiz) from Turkey. , 2007, Journal of agricultural and food chemistry.
[32] P. Barnes,et al. Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule IκB Kinase Inhibitors , 2007, Journal of Pharmacology and Experimental Therapeutics.
[33] M. Egner. Structural Aspects of Drugability and Selectivity of Protein Kinases in Inflammation , 2007 .
[34] T. S. Fröde,et al. Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model. , 2007, Journal of ethnopharmacology.
[35] Jian-Ping Zuo,et al. Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. , 2007, Bioorganic & medicinal chemistry.
[36] Xin Wen,et al. BindingDB: a web-accessible database of experimentally determined protein–ligand binding affinities , 2006, Nucleic Acids Res..
[37] Julie B. Hirsch,et al. Phenolics, inflammation and nutrigenomics , 2006 .
[38] David E. Shaw,et al. PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results , 2006, J. Comput. Aided Mol. Des..
[39] J. Koistinaho,et al. F‐κB modulators from Valeriana officinalis , 2006, Phytotherapy research : PTR.
[40] Aniko Simon,et al. eHiTS: an innovative approach to the docking and scoring function problems. , 2006, Current protein & peptide science.
[41] M. Vinardell,et al. Comparative study of the cytotoxicity induced by antioxidant epicatechin conjugates obtained from grape. , 2006, Journal of agricultural and food chemistry.
[42] P. Proksch,et al. Pongamone A-E, five flavonoids from the stems of a mangrove plant, Pongamia pinnata. , 2006, Phytochemistry.
[43] M. Hepperle,et al. A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells , 2006, Journal of Pharmacology and Experimental Therapeutics.
[44] P. Forgó,et al. Cytotoxic phenanthrenes from the rhizomes of Tamus communis. , 2006, Planta medica.
[45] Hyun Pyo Kim,et al. Anti-inflammatory activity of Ailanthus altissima in ovalbumin-induced lung inflammation. , 2006, Biological & pharmaceutical bulletin.
[46] H. Otsuka,et al. Chemical and biological evaluation on scopadulane-type diterpenoids from Scoparia dulcis of Vietnamese origin. , 2006, Chemical & pharmaceutical bulletin.
[47] T. Lowinger,et al. Small molecule inhibitors of IKK kinase activity , 2006 .
[48] Jae-Kwan Hwang,et al. Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages. , 2005, Fitoterapia.
[49] M. Gibney,et al. The metabolic syndrome: the crossroads of diet and genetics , 2005, The Proceedings of the Nutrition Society.
[50] C. Liaw,et al. Potential Anti-Inflammatory Activities of Bractelactone and other Compounds Isolated from Fissistigma bracteolatum , 2005 .
[51] Zhen-Yu Chen,et al. Biological properties of baicalein in cardiovascular system. , 2005, Current drug targets. Cardiovascular & haematological disorders.
[52] A. Ardévol,et al. The FASEB Journal express article 10.1096/fj.04-3095fje. Published online January 6, 2005. , 2022 .
[53] M. Hayashi,et al. Sesquiterpenoids and plasmin-inhibitory flavonoids from Blumea balsamifera. , 2005, Journal of natural products.
[54] C. Saikia,et al. Isolation of colour components from native dye-bearing plants in northeastern India. , 2005, Bioresource technology.
[55] Thierry Langer,et al. LigandScout: 3-D Pharmacophores Derived from Protein-Bound Ligands and Their Use as Virtual Screening Filters , 2005, J. Chem. Inf. Model..
[56] Brian K. Shoichet,et al. ZINC - A Free Database of Commercially Available Compounds for Virtual Screening , 2005, J. Chem. Inf. Model..
[57] A. Ardévol,et al. Antigenotoxic effect of grape seed procyanidin extract in Fao cells submitted to oxidative stress. , 2004, Journal of agricultural and food chemistry.
[58] Thierry Langer,et al. Combining Ethnopharmacology and Virtual Screening for Lead Structure Discovery: COX-Inhibitors as Application Example , 2004, J. Chem. Inf. Model..
[59] Michael Karin,et al. The IKK NF-κB system: a treasure trove for drug development , 2004, Nature Reviews Drug Discovery.
[60] A. Ghannadi,et al. Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. , 2003, Journal of ethnopharmacology.
[61] M. Reilly,et al. The Metabolic Syndrome: More Than the Sum of Its Parts? , 2003, Circulation.
[62] J. Adams,et al. Novel IKK inhibitors: β-carbolines , 2003 .
[63] Tomomi Takayanagi,et al. Sesquiterpene lactone glucosides and alkyl glycosides from the fruit of cumin. , 2003, Phytochemistry.
[64] M. Choudhary,et al. Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica. , 2003, Journal of ethnopharmacology.
[65] P. Houghton,et al. An evaluation of the activity related to inflammation of four plants used in Thailand to treat arthritis. , 2003, Journal of ethnopharmacology.
[66] Jing Ma,et al. Supplementation of diets with the black rice pigment fraction attenuates atherosclerotic plaque formation in apolipoprotein e deficient mice. , 2003, The Journal of nutrition.
[67] J. Padikkala,et al. Antiatherogenic effect of Caps HT2, a herbal Ayurvedic medicine formulation. , 2003, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[68] M. Kobori,et al. Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins. , 2003, Journal of agricultural and food chemistry.
[69] Chieh-fu Chen,et al. Evodia rutaecarpa protects against circulation failure and organ dysfunction in endotoxaemic rats through modulating nitric oxide release , 2002, The Journal of pharmacy and pharmacology.
[70] S. Rajagopal,et al. Hypolipidemic effect of Cuminum cyminum L. on alloxan-induced diabetic rats. , 2002, Pharmacological research.
[71] J. Ríos,et al. Antioxidant activity of anti-inflammatory plant extracts. , 2002, Life sciences.
[72] G. Mazza,et al. Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages. , 2002, Journal of agricultural and food chemistry.
[73] V. R. Prakash,et al. Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats. , 2001, Journal of ethnopharmacology.
[74] J. Torres,et al. New flavanol derivatives from grape (Vitis vinifera) byproducts. Antioxidant aminoethylthio-flavan-3-ol conjugates from a polymeric waste fraction used as a source of flavanols. , 2001, Journal of agricultural and food chemistry.
[75] K. Yasuda,et al. Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.). , 2001, Journal of agricultural and food chemistry.
[76] M. Al-Ghamdi,et al. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. , 2001, Journal of ethnopharmacology.
[77] J. van Staden,et al. An investigation on the biological activity of Combretum species. , 2001, Journal of ethnopharmacology.
[78] K. Satoh,et al. The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. , 2000, Biological & pharmaceutical bulletin.
[79] Hyun Pyo Kim,et al. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. , 1999, Biochemical pharmacology.
[80] S. Das,et al. Chemical Constituents of Plumbago indica Roots and Reactions of Plumbagin: Part 2. , 1999 .
[81] A. Rojas,et al. Nitric oxide/cGMP mediates the spasmolytic action of 3,4'-dihydroxy-5,5'-dimethoxybibenzyl from Scaphyglottis livida. , 1999, Planta medica.
[82] Sabri,et al. New sesquiterpenoids from the jordanian medicinal plant inula viscosa , 1998, Journal of natural products.
[83] Chieh-fu Chen,et al. 6-methoxy-N-methyl-1 ,2,3,4-tetrahydro-β-carboline from evodiae Fructus , 1997 .
[84] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .
[85] J. Harborne,et al. Phytoalexin induction in the sapwood of plants of the Maloideae (Rosaceae): Biphenyls or dibenzofurans , 1995 .
[86] C. Ni,et al. Nigellidine — A new indazole alkaloid from the seeds of Nigella sativa , 1995 .
[87] E. Malan,et al. Substituted bibenzyls, phenanthrenes and 9,10-dihydrophenanthrenes from the heartwood of Combretum Apiculatum , 1993 .
[88] V. Wray,et al. Biosynthesis of serotonin and β-carboline alkaloids in hairy root cultures of Peganum harmala , 1993 .
[89] E. Pereira,et al. Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities. , 1991, Memorias do Instituto Oswaldo Cruz.
[90] N. F. Roque,et al. Analgesic activity of a triterpene isolated from Scoparia dulcis L. (Vassourinha). , 1991, Memorias do Instituto Oswaldo Cruz.
[91] M. Gupta,et al. FRUIT CONSTITUENT OF PHYSALIS MINIMA VAR. INDICA AND ONE-STEP CONVERSION OF PHYSALIN B TO 6-EPIPHYSALIAN G ACETATE , 1990 .
[92] N. Mascolo,et al. Local anti-inflammatory activity of Tamus communis. , 1987, Journal of ethnopharmacology.
[93] D. G. Watson,et al. Pigment formation by callus of Lavandula angustifolia , 1985 .
[94] K. Koike,et al. Studies on the Alkaloids from Picrasma quassioides BENNET. V. Structures of Picrasidines L, M, and P , 1985 .
[95] L. Crombie,et al. Natural products of Thailand high Δ1-THC-strain Cannabis. The bibenzyl-spiran-dihydrophenanthrene group: relations with cannabinoids and canniflavones , 1982 .
[96] B. Ahn,et al. Siamin, ein neues isochinolon-derivat aus cassia siamea , 1976 .
[97] J. Lutomski,et al. Pharmacochemical investigations of the raw materials from passiflora genus. 2. The pharmacochemical estimation of juices from the fruits of Passiflora edulis and Passiflora edulis forma flavicarpa. , 1975, Planta medica.
[98] M. Slaytor,et al. New natural products from Peganum harmala , 1975 .
[99] O. Gottlieb,et al. The flavones of Apuleia leiocarpa , 1971 .
[100] K. Torssell,et al. Isolation, structure and synthesis of alkaloids from Valeriana officinalis L. , 1967, Acta chemica Scandinavica.