Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activity.

[1]  V. Zoete,et al.  Identification of Human IKK-2 Inhibitors of Natural Origin (Part I): Modeling of the IKK-2 Kinase Domain, Virtual Screening and Activity Assays , 2011, PloS one.

[2]  Sung-Hoon Kim,et al.  Inhibitory Effects of Paeonia suffruticosa on Allergic Reactions by Inhibiting the NF-kappaB/IkappaB-alpha Signaling Pathway and Phosphorylation of ERK in an Animal Model and Human Mast Cells , 2010, Bioscience, biotechnology, and biochemistry.

[3]  W. Ko,et al.  Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia. , 2010, European journal of pharmacology.

[4]  A. Tiwari,et al.  Gastroprotective flavonoid constituents from Oroxylum indicum Vent. , 2010, Bioorganic & medicinal chemistry letters.

[5]  I. Lemieux,et al.  Obesity, Inflammation, and Cardiovascular Risk , 2010, Clinical pharmacology and therapeutics.

[6]  M. Číž,et al.  Serotonin and its 5-HT(2) receptor agonist DOI hydrochloride inhibit the oxidative burst in total leukocytes but not in isolated neutrophils. , 2010, Life sciences.

[7]  X. Yao,et al.  Quassidines A-D, bis-beta-carboline alkaloids from the stems of Picrasma quassioides. , 2010, Journal of Natural Products.

[8]  A. Abena,et al.  Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts. , 2010, Journal of ethnopharmacology.

[9]  I. Matsui‐yuasa,et al.  Anti‐obesity effect of blumea balsamifera extract in 3T3‐L1 preadipocytes and adipocytes , 2010, The American journal of Chinese medicine.

[10]  B. Shim,et al.  Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. , 2009, Journal of ethnopharmacology.

[11]  J. Vita,et al.  Grapes and cardiovascular disease. , 2009, The Journal of nutrition.

[12]  P. Tansakul,et al.  Anti-inflammatory mechanism of Kaempferia parviflora in murine macrophage cells (RAW 264.7) and in experimental animals. , 2009, Journal of ethnopharmacology.

[13]  B. Fiebich,et al.  Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other pro-inflammatory mediators. , 2009, Journal of ethnopharmacology.

[14]  J. M. Mateo-Sanz,et al.  3D-QSAR Study of Pyridine Derivates as IKK-2 Inhibitors , 2009 .

[15]  H. Khan,et al.  Anti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn , 2009, Journal of enzyme inhibition and medicinal chemistry.

[16]  G. Pujadas,et al.  In vivo, in vitro, and in silico studies of Cu/Zn-superoxide dismutase regulation by molecules in grape seed procyanidin extract. , 2009, Journal of agricultural and food chemistry.

[17]  M. Karst,et al.  The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function , 2009, Pharmacology.

[18]  D. Kaul,et al.  Inhibitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease , 2009, Platelets.

[19]  G. Hotamisligil,et al.  Nutrient sensing and inflammation in metabolic diseases , 2008, Nature Reviews Immunology.

[20]  D. Hou,et al.  Expression Profiling of Genes Targeted by Bilberry (Vaccinium myrtillus) in Macrophages Through DNA Microarray , 2008, Nutrition and cancer.

[21]  H. Kikuzaki,et al.  Phenolic glycosides from Kaempferia parviflora. , 2008, Phytochemistry.

[22]  Olivier Sperandio,et al.  FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects , 2008, BMC Bioinformatics.

[23]  Yu Lin,et al.  Comparison with Various Parts of Broussonetia papyrifera as to the Antinociceptive and Anti-Inflammatory Activities in Rodents , 2008, Bioscience, biotechnology, and biochemistry.

[24]  N. Menković,et al.  Anti-inflammatory, gastroprotective, free-radical-scavenging, and antimicrobial activities of hawthorn berries ethanol extract. , 2008, Journal of agricultural and food chemistry.

[25]  Prabhjot Singh,et al.  Piper longum Linn. Extract inhibits TNF-α-induced expression of cell adhesion molecules by inhibiting NF-κB activation and microsomal lipid peroxidation , 2008 .

[26]  J. Schmid,et al.  IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB. , 2008, Cytokine & growth factor reviews.

[27]  Jae Yeon Kim,et al.  In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. , 2008, Bioorganic & medicinal chemistry letters.

[28]  T. Hwang,et al.  Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae. , 2008, Journal of natural products.

[29]  M. Déciga-Campos,et al.  Antinociceptive and anti-inflammatory effects of compounds isolated from Scaphyglottis livida and Maxillaria densa. , 2007, Journal of ethnopharmacology.

[30]  J. Seckl,et al.  Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a promising therapeutic target. , 2007, Drug discovery today.

[31]  V. Uylaşer,et al.  Effect of brining on biological activity of leaves of Vitis vinifera L. (Cv. Sultani Cekirdeksiz) from Turkey. , 2007, Journal of agricultural and food chemistry.

[32]  P. Barnes,et al.  Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule IκB Kinase Inhibitors , 2007, Journal of Pharmacology and Experimental Therapeutics.

[33]  M. Egner Structural Aspects of Drugability and Selectivity of Protein Kinases in Inflammation , 2007 .

[34]  T. S. Fröde,et al.  Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model. , 2007, Journal of ethnopharmacology.

[35]  Jian-Ping Zuo,et al.  Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. , 2007, Bioorganic & medicinal chemistry.

[36]  Xin Wen,et al.  BindingDB: a web-accessible database of experimentally determined protein–ligand binding affinities , 2006, Nucleic Acids Res..

[37]  Julie B. Hirsch,et al.  Phenolics, inflammation and nutrigenomics , 2006 .

[38]  David E. Shaw,et al.  PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results , 2006, J. Comput. Aided Mol. Des..

[39]  J. Koistinaho,et al.  F‐κB modulators from Valeriana officinalis , 2006, Phytotherapy research : PTR.

[40]  Aniko Simon,et al.  eHiTS: an innovative approach to the docking and scoring function problems. , 2006, Current protein & peptide science.

[41]  M. Vinardell,et al.  Comparative study of the cytotoxicity induced by antioxidant epicatechin conjugates obtained from grape. , 2006, Journal of agricultural and food chemistry.

[42]  P. Proksch,et al.  Pongamone A-E, five flavonoids from the stems of a mangrove plant, Pongamia pinnata. , 2006, Phytochemistry.

[43]  M. Hepperle,et al.  A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells , 2006, Journal of Pharmacology and Experimental Therapeutics.

[44]  P. Forgó,et al.  Cytotoxic phenanthrenes from the rhizomes of Tamus communis. , 2006, Planta medica.

[45]  Hyun Pyo Kim,et al.  Anti-inflammatory activity of Ailanthus altissima in ovalbumin-induced lung inflammation. , 2006, Biological & pharmaceutical bulletin.

[46]  H. Otsuka,et al.  Chemical and biological evaluation on scopadulane-type diterpenoids from Scoparia dulcis of Vietnamese origin. , 2006, Chemical & pharmaceutical bulletin.

[47]  T. Lowinger,et al.  Small molecule inhibitors of IKK kinase activity , 2006 .

[48]  Jae-Kwan Hwang,et al.  Effects of Morus alba leaf extract on the production of nitric oxide, prostaglandin E2 and cytokines in RAW264.7 macrophages. , 2005, Fitoterapia.

[49]  M. Gibney,et al.  The metabolic syndrome: the crossroads of diet and genetics , 2005, The Proceedings of the Nutrition Society.

[50]  C. Liaw,et al.  Potential Anti-Inflammatory Activities of Bractelactone and other Compounds Isolated from Fissistigma bracteolatum , 2005 .

[51]  Zhen-Yu Chen,et al.  Biological properties of baicalein in cardiovascular system. , 2005, Current drug targets. Cardiovascular & haematological disorders.

[52]  A. Ardévol,et al.  The FASEB Journal express article 10.1096/fj.04-3095fje. Published online January 6, 2005. , 2022 .

[53]  M. Hayashi,et al.  Sesquiterpenoids and plasmin-inhibitory flavonoids from Blumea balsamifera. , 2005, Journal of natural products.

[54]  C. Saikia,et al.  Isolation of colour components from native dye-bearing plants in northeastern India. , 2005, Bioresource technology.

[55]  Thierry Langer,et al.  LigandScout: 3-D Pharmacophores Derived from Protein-Bound Ligands and Their Use as Virtual Screening Filters , 2005, J. Chem. Inf. Model..

[56]  Brian K. Shoichet,et al.  ZINC - A Free Database of Commercially Available Compounds for Virtual Screening , 2005, J. Chem. Inf. Model..

[57]  A. Ardévol,et al.  Antigenotoxic effect of grape seed procyanidin extract in Fao cells submitted to oxidative stress. , 2004, Journal of agricultural and food chemistry.

[58]  Thierry Langer,et al.  Combining Ethnopharmacology and Virtual Screening for Lead Structure Discovery: COX-Inhibitors as Application Example , 2004, J. Chem. Inf. Model..

[59]  Michael Karin,et al.  The IKK NF-κB system: a treasure trove for drug development , 2004, Nature Reviews Drug Discovery.

[60]  A. Ghannadi,et al.  Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. , 2003, Journal of ethnopharmacology.

[61]  M. Reilly,et al.  The Metabolic Syndrome: More Than the Sum of Its Parts? , 2003, Circulation.

[62]  J. Adams,et al.  Novel IKK inhibitors: β-carbolines , 2003 .

[63]  Tomomi Takayanagi,et al.  Sesquiterpene lactone glucosides and alkyl glycosides from the fruit of cumin. , 2003, Phytochemistry.

[64]  M. Choudhary,et al.  Anti-inflammatory isoflavonoids from the rhizomes of Iris germanica. , 2003, Journal of ethnopharmacology.

[65]  P. Houghton,et al.  An evaluation of the activity related to inflammation of four plants used in Thailand to treat arthritis. , 2003, Journal of ethnopharmacology.

[66]  Jing Ma,et al.  Supplementation of diets with the black rice pigment fraction attenuates atherosclerotic plaque formation in apolipoprotein e deficient mice. , 2003, The Journal of nutrition.

[67]  J. Padikkala,et al.  Antiatherogenic effect of Caps HT2, a herbal Ayurvedic medicine formulation. , 2003, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[68]  M. Kobori,et al.  Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins. , 2003, Journal of agricultural and food chemistry.

[69]  Chieh-fu Chen,et al.  Evodia rutaecarpa protects against circulation failure and organ dysfunction in endotoxaemic rats through modulating nitric oxide release , 2002, The Journal of pharmacy and pharmacology.

[70]  S. Rajagopal,et al.  Hypolipidemic effect of Cuminum cyminum L. on alloxan-induced diabetic rats. , 2002, Pharmacological research.

[71]  J. Ríos,et al.  Antioxidant activity of anti-inflammatory plant extracts. , 2002, Life sciences.

[72]  G. Mazza,et al.  Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages. , 2002, Journal of agricultural and food chemistry.

[73]  V. R. Prakash,et al.  Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats. , 2001, Journal of ethnopharmacology.

[74]  J. Torres,et al.  New flavanol derivatives from grape (Vitis vinifera) byproducts. Antioxidant aminoethylthio-flavan-3-ol conjugates from a polymeric waste fraction used as a source of flavanols. , 2001, Journal of agricultural and food chemistry.

[75]  K. Yasuda,et al.  Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.). , 2001, Journal of agricultural and food chemistry.

[76]  M. Al-Ghamdi,et al.  The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. , 2001, Journal of ethnopharmacology.

[77]  J. van Staden,et al.  An investigation on the biological activity of Combretum species. , 2001, Journal of ethnopharmacology.

[78]  K. Satoh,et al.  The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. , 2000, Biological & pharmaceutical bulletin.

[79]  Hyun Pyo Kim,et al.  Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. , 1999, Biochemical pharmacology.

[80]  S. Das,et al.  Chemical Constituents of Plumbago indica Roots and Reactions of Plumbagin: Part 2. , 1999 .

[81]  A. Rojas,et al.  Nitric oxide/cGMP mediates the spasmolytic action of 3,4'-dihydroxy-5,5'-dimethoxybibenzyl from Scaphyglottis livida. , 1999, Planta medica.

[82]  Sabri,et al.  New sesquiterpenoids from the jordanian medicinal plant inula viscosa , 1998, Journal of natural products.

[83]  Chieh-fu Chen,et al.  6-methoxy-N-methyl-1 ,2,3,4-tetrahydro-β-carboline from evodiae Fructus , 1997 .

[84]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .

[85]  J. Harborne,et al.  Phytoalexin induction in the sapwood of plants of the Maloideae (Rosaceae): Biphenyls or dibenzofurans , 1995 .

[86]  C. Ni,et al.  Nigellidine — A new indazole alkaloid from the seeds of Nigella sativa , 1995 .

[87]  E. Malan,et al.  Substituted bibenzyls, phenanthrenes and 9,10-dihydrophenanthrenes from the heartwood of Combretum Apiculatum , 1993 .

[88]  V. Wray,et al.  Biosynthesis of serotonin and β-carboline alkaloids in hairy root cultures of Peganum harmala , 1993 .

[89]  E. Pereira,et al.  Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities. , 1991, Memorias do Instituto Oswaldo Cruz.

[90]  N. F. Roque,et al.  Analgesic activity of a triterpene isolated from Scoparia dulcis L. (Vassourinha). , 1991, Memorias do Instituto Oswaldo Cruz.

[91]  M. Gupta,et al.  FRUIT CONSTITUENT OF PHYSALIS MINIMA VAR. INDICA AND ONE-STEP CONVERSION OF PHYSALIN B TO 6-EPIPHYSALIAN G ACETATE , 1990 .

[92]  N. Mascolo,et al.  Local anti-inflammatory activity of Tamus communis. , 1987, Journal of ethnopharmacology.

[93]  D. G. Watson,et al.  Pigment formation by callus of Lavandula angustifolia , 1985 .

[94]  K. Koike,et al.  Studies on the Alkaloids from Picrasma quassioides BENNET. V. Structures of Picrasidines L, M, and P , 1985 .

[95]  L. Crombie,et al.  Natural products of Thailand high Δ1-THC-strain Cannabis. The bibenzyl-spiran-dihydrophenanthrene group: relations with cannabinoids and canniflavones , 1982 .

[96]  B. Ahn,et al.  Siamin, ein neues isochinolon-derivat aus cassia siamea , 1976 .

[97]  J. Lutomski,et al.  Pharmacochemical investigations of the raw materials from passiflora genus. 2. The pharmacochemical estimation of juices from the fruits of Passiflora edulis and Passiflora edulis forma flavicarpa. , 1975, Planta medica.

[98]  M. Slaytor,et al.  New natural products from Peganum harmala , 1975 .

[99]  O. Gottlieb,et al.  The flavones of Apuleia leiocarpa , 1971 .

[100]  K. Torssell,et al.  Isolation, structure and synthesis of alkaloids from Valeriana officinalis L. , 1967, Acta chemica Scandinavica.