Pro‐Inflammatory macrophages increase in skeletal muscle of high fat‐Fed mice and correlate with metabolic risk markers in humans

In obesity, immune cells infiltrate adipose tissue. Skeletal muscle is the major tissue of insulin‐dependent glucose disposal, and indices of muscle inflammation arise during obesity, but whether and which immune cells increase in muscle remain unclear.

[1]  M. Blüher,et al.  Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes , 2013, Diabetologia.

[2]  S. Balk,et al.  Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. , 2012, Immunity.

[3]  J. Olefsky,et al.  The cellular and signaling networks linking the immune system and metabolism in disease , 2012, Nature Medicine.

[4]  E. Ravussin,et al.  Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects , 2012, Obesity.

[5]  J. Olefsky,et al.  Increased Macrophage Migration Into Adipose Tissue in Obese Mice , 2012, Diabetes.

[6]  C. Benoist,et al.  Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. , 2011, Seminars in immunology.

[7]  R. Ransohoff,et al.  Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[8]  R. Schwendener,et al.  Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet–Induced Insulin Resistance , 2011, Diabetes.

[9]  R. Locksley,et al.  Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis , 2011, Science.

[10]  S. Tangye,et al.  Inflammatory Mechanisms in Obesity , 2013 .

[11]  R. Ransohoff,et al.  Macrophages recruited via CCR2 produce insulin‐like growth factor‐1 to repair acute skeletal muscle injury , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  M. Fasshauer,et al.  Insulin-sensitive obesity. , 2010, American journal of physiology. Endocrinology and metabolism.

[13]  Emily K Anderson,et al.  Adipose tissue recruitment of leukocytes , 2010, Current opinion in lipidology.

[14]  S. Gordon,et al.  The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B , 2010, Journal of leukocyte biology.

[15]  G. Smyth,et al.  Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity , 2010, Diabetes.

[16]  H. Shapiro,et al.  Inflammation and adipose tissue macrophages in lipodystrophic mice , 2009, Proceedings of the National Academy of Sciences.

[17]  A. Saltiel,et al.  MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity , 2009, The Journal of experimental medicine.

[18]  R. Friedline,et al.  Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle , 2009, Diabetes.

[19]  Christophe Benoist,et al.  Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters , 2009, Nature Medicine.

[20]  C. Peterson,et al.  Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. , 2009, American journal of physiology. Endocrinology and metabolism.

[21]  Y. Hirata,et al.  Role of CC Chemokine Receptor 2 in Bone Marrow Cells in the Recruitment of Macrophages into Obese Adipose Tissue* , 2008, Journal of Biological Chemistry.

[22]  A. Saltiel,et al.  Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes , 2008, Diabetes.

[23]  J. Olefsky,et al.  Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. , 2008, Cell Metabolism.

[24]  Peter Widmayer,et al.  Genevestigator V3: A Reference Expression Database for the Meta-Analysis of Transcriptomes , 2008, Adv. Bioinformatics.

[25]  C. Glass,et al.  A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways* , 2007, Journal of Biological Chemistry.

[26]  Graham M Lord,et al.  Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue , 2007, Diabetes.

[27]  C. Glass,et al.  Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. , 2007, The Journal of clinical investigation.

[28]  Ofer Levy,et al.  Innate immunity of the newborn: basic mechanisms and clinical correlates , 2007, Nature Reviews Immunology.

[29]  A. Saltiel,et al.  Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity , 2007, Diabetes.

[30]  C. Mantzoros,et al.  Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training. , 2006, The Journal of clinical endocrinology and metabolism.

[31]  R. Kitazawa,et al.  MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. , 2006, The Journal of clinical investigation.

[32]  J. Helge,et al.  Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. , 2006, American journal of physiology. Endocrinology and metabolism.

[33]  C. Peterson,et al.  Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. , 2005, Diabetes.

[34]  S. Batalov,et al.  A gene atlas of the mouse and human protein-encoding transcriptomes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[35]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[36]  S. Gordon,et al.  Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo , 2003, European journal of immunology.

[37]  M. Albert,et al.  Muscle resident macrophages control the immune cell reaction in a mouse model of notexin-induced myoinjury. , 2010, Arthritis and rheumatism.