Theiler’s virus infection chronically alters seizure susceptibility

Purpose:  Central nervous system infections greatly increase the risk for the development of seizures and epilepsy (recurrent unprovoked seizures). We have previously shown that Theiler’s murine encephalomyelitis virus (Theiler’s virus or TMEV) infection causes acute symptomatic seizures in C57BL/6 (B6) mice. The objective of the present study was threefold: (1) to assess pathologic changes associated with acute TMEV infection and infection‐induced seizures, (2) to determine whether Theiler’s virus infection and associated acute seizures lead to chronically altered seizure susceptibility, and (3) to determine whether genetic background influences seizure susceptibility following Theiler’s virus infection.

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