Response Surface and Factorial Designs for Combination Antihypertensive Drugs*

A C O U P L E O F YEARS ago, a drug sponsor started using a multifactorial de­ sign trial to study the combination of two antihypertensive agents for the treatment of hypertension. Subsequently, we have often been asked whether response surface method is acceptable in the analysis of da­ ta gathered from a factorial design trial. In this paper we share with you some of our thoughts on this matter with a focus on combination antihypertensive drugs. However, most of our comments and