MIRD Pamphlet No. 24: Guidelines for Quantitative 131I SPECT in Dosimetry Applications

The reliability of radiation dose estimates in internal radionuclide therapy is directly related to the accuracy of activity estimates obtained at each imaging time point. The recently published MIRD pamphlet no. 23 provided a general overview of quantitative SPECT imaging for dosimetry. The present document is the first in a series of isotope-specific guidelines that will follow MIRD 23 and focuses on one of the most commonly used therapeutic radionuclides, 131I. The purpose of this document is to provide guidance on the development of protocols for quantitative 131I SPECT in radionuclide therapy applications that require regional (normal organs, lesions) and 3-dimensional dosimetry.

[1]  Improved dose-volume histogram estimates for radiopharmaceutical therapy by optimizing quantitative SPECT reconstruction parameters. , 2013, Physics in medicine and biology.

[2]  S. Wilderman,et al.  Method for Fast CT/SPECT-Based 3D Monte Carlo Absorbed Dose Computations in Internal Emitter Therapy , 2007, IEEE Transactions on Nuclear Science.

[3]  M S Rosenthal,et al.  Quantitative SPECT imaging: a review and recommendations by the Focus Committee of the Society of Nuclear Medicine Computer and Instrumentation Council. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  Joachim Hornegger,et al.  Quantitative Accuracy of Clinical 99mTc SPECT/CT Using Ordered-Subset Expectation Maximization with 3-Dimensional Resolution Recovery, Attenuation, and Scatter Correction , 2010, Journal of Nuclear Medicine.

[5]  M. Kaminski,et al.  Prediction of therapy tumor-absorbed dose estimates in I-131 radioimmunotherapy using tracer data via a mixed-model fit to time activity. , 2012, Cancer biotherapy & radiopharmaceuticals.

[6]  M. Ljungberg,et al.  A Monte Carlo program for the simulation of scintillation camera characteristics. , 1989, Computer methods and programs in biomedicine.

[7]  K. Koral,et al.  Deadtime correction for two multihead Anger cameras in 131I dual-energy-window-acquisition mode. , 1998, Medical physics.

[8]  M. Gaze,et al.  Dosimetry for fractionated (131)I-mIBG therapies in patients with primary resistant high-risk neuroblastoma: preliminary results. , 2007, Cancer biotherapy & radiopharmaceuticals.

[9]  J. Fessler,et al.  Regularized reconstruction in quantitative SPECT using CT side information from hybrid imaging , 2010, Physics in medicine and biology.

[10]  Hanna Piwowarska-Bilska,et al.  The accuracy and reproducibility of SPECT target volumes and activities estimated using an iterative adaptive thresholding technique , 2012, Nuclear medicine communications.

[11]  Eric C Frey,et al.  The impact of 3D volume of interest definition on accuracy and precision of activity estimation in quantitative SPECT and planar processing methods , 2010, Physics in medicine and biology.

[12]  George Sgouros,et al.  Lung dosimetry for radioiodine treatment planning in the case of diffuse lung metastases. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[13]  D Front,et al.  SPECT quantitation of iodine-131 concentration in phantoms and human tumors. , 1990, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[15]  S Shcherbinin,et al.  Accuracy of quantitative reconstructions in SPECT/CT imaging , 2008, Physics in medicine and biology.

[16]  Eric C Frey,et al.  Development and evaluation of a model-based downscatter compensation method for quantitative I-131 SPECT. , 2011, Medical physics.

[17]  H R Tang,et al.  Neuroblastoma imaging using a combined CT scanner-scintillation camera and 131I-MIBG. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[18]  E. Frey,et al.  Effects of shortened acquisition time on accuracy and precision of quantitative estimates of organ activity. , 2010, Medical physics.

[19]  M. Kaminski,et al.  Use of integrated SPECT/CT imaging for tumor dosimetry in I-131 radioimmunotherapy: a pilot patient study. , 2009, Cancer biotherapy & radiopharmaceuticals.

[20]  M H Loew,et al.  Threshold estimation in single photon emission computed tomography and planar imaging for clinical radioimmunotherapy. , 1995, Cancer research.

[21]  F. Berthold,et al.  Dosimetry for 131I-MIBG therapies in metastatic neuroblastoma, phaeochromocytoma and paraganglioma , 2010, European Journal of Nuclear Medicine and Molecular Imaging.

[22]  Yuni K Dewaraja,et al.  131I-Tositumomab Radioimmunotherapy: Initial Tumor Dose–Response Results Using 3-Dimensional Dosimetry Including Radiobiologic Modeling , 2010, Journal of Nuclear Medicine.

[23]  Quantitation in 131 I‐radioimmunotherapy using spect , 1988, International journal of cancer. Supplement = Journal international du cancer. Supplement.

[24]  High-resolution absolute SPECT quantitation for I-131 distributions used in the treatment of lymphoma: a phantom study , 2000 .

[25]  A. Yendiki,et al.  Comparison of 3-D OSEM versus 1-D SAGE for focal total-activity quantification in I-131 SPECT with HE collimation , 2005, IEEE Transactions on Nuclear Science.

[26]  K. Kearfott,et al.  Comparison of I-131 radioimmunotherapy tumor dosimetry: unit density sphere model versus patient-specific Monte Carlo calculations. , 2011, Cancer biotherapy & radiopharmaceuticals.

[27]  Jm Pereira,et al.  IMAGE QUANTIFICATION FOR RADIATION DOSE CALCULATIONS—LIMITATIONS AND UNCERTAINTIES , 2010, Health physics.

[28]  Yuni K. Dewaraja,et al.  MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy , 2012, The Journal of Nuclear Medicine.