Calculation of risk factors and likelihoods for familial diseases.

Abstract This paper presents a method for solving two related problems in pedigree analysis. The first application involves fitting familial modes of transmission of a trait to pedigree data and includes chromosome linkage studies as a special case. The second application involves calculating the probability that a person will be affected with a disease given a model. Genetic, environmental, and combined models can be considered. Pedigrees of any complexity, including consanguinity, can be handled. The risks and likelihoods are calculated as coefficients of polynomials in the gene-frequencies rather than numerically. FORTRAN programs are available on request.

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