Occupational allergic contact dermatitis caused by isocyanates

Between 1978 and 2001, 22 patients were diagnosed with occupation‐related allergic contact dermatitis from isocyanates and/or polyurethanes in our clinic. 13 had a positive reaction to the isocyanates, of whom 10 also reacted to diaminodiphenylmethane (MDA), which is used in the production or processing of isocyanates and polyurethanes; 9 reacted only to MDA. The object of the present study was to identify the trades and industries responsible for the development of contact allergy to these resins. Such patients must be patch tested with the isocyanates contacted at work, and account must be taken of positive reactions to MDA as a marker for isocyanate sensitivity.

[1]  G. Jemec,et al.  Skin irritation and exposure to diisocyanates in orthopedic nurses working with soft casts. , 2001, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

[2]  T. Estlander,et al.  Asthma from diisocyanates is not mediated through a Type IV, patch‐test‐positive mechanism , 2001, Contact dermatitis.

[3]  M R Cullen,et al.  Qualitative assessment of isocyanate skin exposure in auto body shops: a pilot study. , 2000, American journal of industrial medicine.

[4]  P. Frosch,et al.  Kunststoffe : chemische Grundlagen, Verwendung und Bedeutung als Kontaktallergene , 2000 .

[5]  C. Coz,et al.  Active sensitization to toluene di‐isocyanate , 1999, Contact dermatitis.

[6]  W. Uter,et al.  Occupational allergic contact dermatitis, partly airborne, due to isocyanates and epoxy resin , 1999, Contact dermatitis.

[7]  P. Piirilä,et al.  Occupational IgE‐mediated contact urticaria from diphenylmethane‐4,4′‐diisocyanate (MDI) , 1999, Contact dermatitis.

[8]  M. G. Ott,et al.  Diisocyanates in polyurethane plastics applications. , 1999, Occupational medicine.

[9]  S. Binet,et al.  Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs , 1998, Contact dermatitis.

[10]  D. Belsito,et al.  Allergic contact dermatitis from a diisocyanate in wool processing , 1997, Contact dermatitis.

[11]  J. Guin.  Reviews and Notes: Practical Contact Dermatitis: A Handbook for the Practitioner , 1995, Annals of Internal Medicine.

[12]  X. Baur,et al.  Respiratory and other hazards of isocyanates , 1994, International archives of occupational and environmental health.

[13]  H. Keskinen,et al.  Occupational dermatitis from exposure to polyurethane chemicals , 1992, Contact dermatitis.

[14]  P. Thorne,et al.  Contact sensitivity by diisocyanates: potencies and cross-reactivities. , 1987, Toxicology and applied pharmacology.

[15]  S. Gad,et al.  Development and validation of an alternative dermal sensitization test: the mouse ear swelling test (MEST). , 1986, Toxicology and applied pharmacology.

[16]  R. Rycroft,et al.  Allergic contact dermatitis from an organic di‐isocyanate , 1983, Contact dermatitis.

[17]  P F Woolrich,et al.  Toxicology, industrial hygiene and medical control of TDI, MDI and PMPPI. , 1982, American Industrial Hygiene Association journal.

[18]  K. Malten.  4,4′ Diisocyanato dicyclohexyl methane (Hylene W): A strong contact sensitizer , 1977, Contact dermatitis.

[19]  A. Rothe.  Occupational disorders of the skin due to chemicals used in polyurcthane processing. , 1976 .

[20]  P. Wodniansky.  Skin lesions in the manufacture of polyurethanes. , 1967 .

[21]  N. Rudolph,et al.  [Plastic materials]. , 2018, Ugeskrift for laeger.

[22]  A. Wurtz.  Ueber die Verbindungen der Cyanursäure und Cyansäure mit Aethyloxyd, Methyloxyd, Amyloxyd und die daraus entstehenden Producte; Acetyl‐ und Metacetylharnstoff, Methylamin, Aethylamin, Valeramin , 1849 .