Nuclear speckle integrity and function require TAO2 kinase

Significance In these studies, TAO2 kinase has been revealed as a constituent and key player in nuclear speckle structure and function, including RNA splicing and nuclear export. These findings add knowledge to the cell biology of nuclear body assembly, RNA processing, and influenza virus infection, as this human pathogen utilizes nuclear speckles for generating a spliced product that is critical for viral entry and budding. Thus, regulation of TAO2 activity may be considered a therapeutic strategy for targeting influenza virus.

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