Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction.

[1]  Mengjie Liang,et al.  Screening and validation of differentially expressed genes in adipose tissue of patients with obesity and type 2 diabetes mellitus , 2023, Biomolecules & biomedicine.

[2]  M. Chikri,et al.  Transcriptomic Analysis from Normal Glucose Tolerance to T2D of Obese Individuals Using Bioinformatic Tools , 2023, International journal of molecular sciences.

[3]  S. Kwon,et al.  TNFα-induced NLRP3 inflammasome mediates adipocyte dysfunction and activates macrophages through adipocyte-derived lipocalin 2. , 2023, Metabolism: clinical and experimental.

[4]  Hanmei Xu,et al.  Trends in insulin resistance: insights into mechanisms and therapeutic strategy , 2022, Signal Transduction and Targeted Therapy.

[5]  J. Hunter,et al.  The role of hyperinsulinaemia in screening for prediabetes in the adolescent population: A systematic literature review. , 2022, Diabetes & metabolic syndrome.

[6]  S. Klein,et al.  Why does obesity cause diabetes? , 2022, Cell metabolism.

[7]  M. Jensen,et al.  Adipose Tissue Inflammation is Not Related to Adipose Insulin Resistance in Humans. , 2021, Diabetes.

[8]  M. Haluzík,et al.  Adipose tissue immune cells in obesity, type 2 diabetes mellitus and cardiovascular diseases. , 2021, The Journal of endocrinology.

[9]  Nicholas J. Carruthers,et al.  The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity , 2021, Scientific Reports.

[10]  Xiaochen Bo,et al.  clusterProfiler 4.0: A universal enrichment tool for interpreting omics data , 2021, Innovation.

[11]  S. Klein,et al.  Associations among adipose tissue immunology, inflammation and exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease. , 2021, Gastroenterology.

[12]  M. Mann,et al.  Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues , 2021, bioRxiv.

[13]  P. Matafome,et al.  Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes , 2021, Molecular metabolism.

[14]  Joanna Kalucka,et al.  Angiogenesis in Adipose Tissue: The Interplay Between Adipose and Endothelial Cells , 2021, Frontiers in Physiology.

[15]  Sujoy Ghosh,et al.  Metabolic Health Status Contributes to Transcriptome Alternation in Human Visceral Adipose Tissue During Obesity , 2020, Obesity.

[16]  P. Matafome,et al.  GLP-1 improves adipose tissue glyoxalase activity and capillarization improving insulin sensitivity in type 2 diabetes. , 2020, Pharmacological research.

[17]  N. Stefan.  Causes, consequences, and treatment of metabolically unhealthy fat distribution. , 2020, The lancet. Diabetes & endocrinology.

[18]  K. Manolopoulos,et al.  Oxygenation of adipose tissue: A human perspective , 2019, Acta physiologica.

[19]  P. Matafome,et al.  Effect of Sleeve Gastrectomy on Angiogenesis and Adipose Tissue Health in an Obese Animal Model of Type 2 Diabetes , 2019, Obesity Surgery.

[20]  S. Menini,et al.  Metabolically healthy versus metabolically unhealthy obesity. , 2019, Metabolism: clinical and experimental.

[21]  Edward T Chouchani,et al.  Metabolic adaptation and maladaptation in adipose tissue , 2019, Nature Metabolism.

[22]  M. Kratz,et al.  Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus. , 2018, Comprehensive Physiology.

[23]  Guihua Liu,et al.  The PI3K/AKT pathway in obesity and type 2 diabetes , 2018, International journal of biological sciences.

[24]  M. Castelo‐Branco,et al.  Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance , 2017, Scientific Reports.

[25]  K. Clément,et al.  A PDGFRα-Mediated Switch toward CD9high Adipocyte Progenitors Controls Obesity-Induced Adipose Tissue Fibrosis. , 2017, Cell metabolism.

[26]  P. Scherer,et al.  The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. , 2017, The Journal of clinical investigation.

[27]  M. Blüher.  Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance? , 2016, Clinical science.

[28]  Samuel E. Jones,et al.  Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease , 2016, Diabetes.

[29]  P. Kern,et al.  Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects. , 2016, The Journal of clinical endocrinology and metabolism.

[30]  L. Landini,et al.  Adipose Tissue Oxygenation in Obesity: A Matter of Cardiovascular Risk? , 2015, Current pharmaceutical design.

[31]  H. Kaufman,et al.  Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis , 2015, Nature Reviews Drug Discovery.

[32]  S. Merali,et al.  Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men , 2015, Science Translational Medicine.

[33]  P. Gentileschi,et al.  Omental adipose tissue fibrosis and insulin resistance in severe obesity , 2015, Nutrition & Diabetes.

[34]  P. Matafome,et al.  Glycation and Hypoxia: Two Key Factors for Adipose Tissue Dysfunction. , 2015, Current medicinal chemistry.

[35]  E. Layunta,et al.  IL-10 Counteracts Proinflammatory Mediator Evoked Oxidative Stress in Caco-2 Cells , 2014, Mediators of inflammation.

[36]  C. Lumeng,et al.  Macrophages and the regulation of adipose tissue remodeling. , 2014, Annual review of nutrition.

[37]  D. Bernlohr,et al.  Oxidative stress and protein carbonylation in adipose tissue - implications for insulin resistance and diabetes mellitus. , 2013, Journal of proteomics.

[38]  M. Cerf.  Beta Cell Dysfunction and Insulin Resistance , 2013, Front. Endocrinol..

[39]  S. Davidge,et al.  The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives. , 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

[40]  L. Yvan-Charvet,et al.  Role of adipose tissue renin-angiotensin system in metabolic and inflammatory diseases associated with obesity. , 2011, Kidney international.

[41]  Z. Kováčová,et al.  Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response. , 2010, The Journal of clinical endocrinology and metabolism.

[42]  B. Kieć-Wilk,et al.  The adipose tissue gene expression in mice with different nitric oxide availability. , 2010, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[43]  F. Paccaud,et al.  Metabolically healthy obesity: different prevalences using different criteria , 2010, European Journal of Clinical Nutrition.

[44]  J. Rood,et al.  Reduced Adipose Tissue Oxygenation in Human Obesity , 2009, Diabetes.

[45]  C. Aguilar-Salinas,et al.  High adiponectin concentrations are associated with the metabolically healthy obese phenotype. , 2008, The Journal of clinical endocrinology and metabolism.

[46]  Lokesh Kumar,et al.  Mfuzz: A software package for soft clustering of microarray data , 2007, Bioinformation.

[47]  A. Baranova,et al.  Obesity-related Differential Gene Expression in the Visceral Adipose Tissue , 2005, Obesity surgery.

[48]  Morihiro Matsuda,et al.  Increased oxidative stress in obesity and its impact on metabolic syndrome. , 2004, The Journal of clinical investigation.

[49]  S. Romagnani,et al.  T-cell subsets (Th1 versus Th2). , 2000, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[50]  J. Levy,et al.  Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer Program , 1998, Diabetes Care.

[51]  Shammamah Hossain,et al.  Visualization of Bioinformatics Data with Dash Bio , 2019, SciPy.

[52]  R. Seiça,et al.  Function and Dysfunction of Adipose Tissue. , 2017, Advances in neurobiology.

[53]  A. Attie,et al.  Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue , 2009, Molecular and Cellular Biology.