Responsive Polymers at the Biology/Materials Science Interface

Synthetic polymers can be prepared with features that combine many of the advantageous properties of natural materials, including environmental response. This Research News article considers the different types of response that can be ‘programmed in' to polymers and the applications that are developing as a consequence of the designed responses. In particular, we focus on two key applications at the biology/materials science interface: responsive drug delivery systems and ‘smart' surfaces for cell culture and regenerative medicine.

[1]  George M. Whitesides,et al.  Millimeter-scale self-assembly and its applications , 2003 .

[2]  V. Rotello,et al.  Controlled recovery of the transcription of nanoparticle-bound DNA by intracellular concentrations of glutathione. , 2005, Bioconjugate chemistry.

[3]  M. Haider,et al.  Genetically engineered polymers: status and prospects for controlled release. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[4]  J. Hubbell,et al.  A hydrogel system for stimulus-responsive, oxygen-sensitive in situ gelation , 2004, Journal of biomaterials science. Polymer edition.

[5]  T. Miyata,et al.  Biomolecule-sensitive hydrogels. , 2002, Advanced drug delivery reviews.

[6]  S. Martin,et al.  Responsive brushes and gels as components of soft nanotechnology. , 2005, Faraday discussions.

[7]  Kinam Park,et al.  Synthesis and characterization of sol–gel phase‐reversible hydrogels sensitive to glucose , 1996, Journal of molecular recognition : JMR.

[8]  R Langer,et al.  Responsive polymeric delivery systems. , 2001, Advanced drug delivery reviews.

[9]  R. Duncan The dawning era of polymer therapeutics , 2003, Nature Reviews Drug Discovery.

[10]  R. Langer,et al.  Light-induced shape-memory polymers , 2005, Nature.

[11]  S. Brocchini,et al.  Polyacetal-diethylstilboestrol: A Polymeric Drug Designed for pH-triggered Activation , 2004, Journal of drug targeting.

[12]  G M Whitesides,et al.  Molecule-mimetic chemistry and mesoscale self-assembly. , 2001, Accounts of chemical research.

[13]  H. Lode,et al.  Bioactivation of self-immolative dendritic prodrugs by catalytic antibody 38C2. , 2004, Journal of the American Chemical Society.

[14]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[15]  Martin Müller,et al.  Oxidation-responsive polymeric vesicles , 2004, Nature materials.

[16]  Lisa Pakstis,et al.  Stimuli-responsive polypeptide vesicles by conformation-specific assembly , 2004, Nature materials.

[17]  T. Shinbo,et al.  Characteristic Phase Transition of Aqueous Solution of Poly(N-isopropylacrylamide) Functionalized with Spirobenzopyran , 2004 .

[18]  K. Ishihara,et al.  Control of insulin permeation through a polymer membrane with responsive function for glucose , 1983 .

[19]  Takashi Miyata,et al.  Preparation of reversibly glucose-responsive hydrogels by covalent immobilization of lectin in polymer networks having pendant glucose , 2004, Journal of biomaterials science. Polymer edition.

[20]  R. Mayadunne,et al.  Synthesis of novel architectures by Radical polymerization with Reversible addition fragmentation chain transfer (RAFT polymerization) , 2003 .

[21]  Hamidreza Ghandehari,et al.  In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[22]  Christopher W. Macosko,et al.  Mechanical Properties of Cross-Linked Synthetic Elastomeric Polypentapeptides , 2001 .

[23]  C. Alexander,et al.  Stimuli responsive polymers for biomedical applications. , 2005, Chemical Society reviews.

[24]  A. Fischman,et al.  Semisynthetic hydrophilic polyals. , 2005, Biomacromolecules.

[25]  A S Hoffman,et al.  Formation of poly(glucosyloxyethyl methacrylate)-concanavalin A complex and its glucose-sensitivity. , 1994, Journal of biomaterials science. Polymer edition.

[26]  Ann Logan,et al.  A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids , 2005, Nucleic acids research.

[27]  Ashutosh Chilkoti,et al.  Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. , 2002, Advanced drug delivery reviews.

[28]  Ipsita Roy,et al.  Smart polymeric materials: emerging biochemical applications. , 2003, Chemistry & biology.

[29]  S. Havelund,et al.  Insulins with built‐in glucose sensors for glucose responsive insulin release , 2005, Journal of peptide science : an official publication of the European Peptide Society.

[30]  Molly M Stevens,et al.  pH-dependent behavior of surface-immobilized artificial leucine zipper proteins. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[31]  R. Lerner,et al.  Single-triggered trimeric prodrugs. , 2005, Angewandte Chemie.

[32]  A. Hoffman,et al.  Smart polymeric carriers for enhanced intracellular delivery of therapeutic macromolecules , 2005, Expert opinion on biological therapy.

[33]  K. Matyjaszewski,et al.  Structural aspects of copper catalyzed atom transfer radical polymerization , 2005 .

[34]  A. Metters,et al.  Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Cameron Alexander,et al.  Control of a multisubunit DNA motor by a thermoresponsive polymer switch. , 2004, Journal of the American Chemical Society.

[36]  Kazuhiko Ishihara,et al.  Glucose‐responsive insulin release from polymer capsule1 , 1986 .

[37]  Akira Matsumoto,et al.  Glucose-responsive polymer gel bearing phenylborate derivative as a glucose-sensing moiety operating at the physiological pH. , 2004, Biomacromolecules.

[38]  T. Yamaoka,et al.  Effects of temperature and pressure on the aggregation properties of an engineered elastin model polypeptide in aqueous solution. , 2000, Biomacromolecules.

[39]  E. Gil,et al.  Stimuli-reponsive polymers and their bioconjugates , 2004 .

[40]  S. Edmondson,et al.  Quasi‐2D Polymer Objects from Patterned, Crosslinked Polymer Brushes , 2004 .

[41]  Kinam Park,et al.  Hydrogels and biodegradable polymers for bioapplications : developed from a symposium sponsored by the Division of Polymer Chemistry, Inc., at the 208th National Meeting of the American Chemical Society, Washington, DC, August 21-26, 1994 , 1996 .

[42]  N. Pessah,et al.  A chemical adaptor system designed to link a tumor-targeting device with a prodrug and an enzymatic trigger. , 2003, Angewandte Chemie.

[43]  S. Jeong,et al.  A glucose-triggered solubilizable polymer gel matrix for an insulin delivery system , 1992 .

[44]  N A Peppas,et al.  Glucose-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly(ethylene glycol) grafts. , 2000, Journal of Controlled Release.

[45]  A. Göpferich,et al.  Biomimetic polymers in pharmaceutical and biomedical sciences. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[46]  W. Huck,et al.  AFM study of cationically charged polymer brushes: switching between soft and hard matter. , 2005, Soft matter.

[47]  T. Okano,et al.  A Self-Regulated Insulin Delivery System Using Boronic Acid Gel , 1994 .

[48]  Richard A Lerner,et al.  Prodrug activation gated by a molecular "OR" logic trigger. , 2005, Angewandte Chemie.

[49]  Samarth Kulkarni,et al.  Photoresponsive polymer–enzyme switches , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[50]  K. Healy,et al.  Synthesis and characterization of injectable poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with proteolytically degradable cross-links. , 2003, Biomacromolecules.

[51]  Toshiyuki Kanamori,et al.  In situ control of cell adhesion using photoresponsive culture surface. , 2005, Biomacromolecules.

[52]  George M. Whitesides,et al.  Self-Assembly of 10-μm-Sized Objects into Ordered Three-Dimensional Arrays , 2001 .

[53]  Jeffrey A Hubbell,et al.  Oxidation-sensitive polymeric nanoparticles. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[54]  J. Hubbell,et al.  Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration. , 2005, Biophysical journal.

[55]  D. Shabat,et al.  New chemical adaptor unit designed to release a drug from a tumor targeting device by enzymatic triggering. , 2004, Bioorganic & medicinal chemistry.

[56]  R. Duncan,et al.  Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[57]  N. Murthy,et al.  A novel strategy for encapsulation and release of proteins: hydrogels and microgels with acid-labile acetal cross-linkers. , 2002, Journal of the American Chemical Society.

[58]  K. Ulbrich,et al.  Polymer‐coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction , 2004, The journal of gene medicine.

[59]  Cameron Alexander,et al.  Protein-polymer nano-machines. Towards synthetic control of biological processes , 2004, Journal of nanobiotechnology.

[60]  Roey J. Amir,et al.  Self-immolative dendrimer biodegradability by multi-enzymatic triggering. , 2004, Chemical communications.

[61]  Xiaoping Zhou,et al.  Macromolecules of controlled architecture , 2003 .

[62]  Ashutosh Chilkoti,et al.  Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[63]  Eric P. Holowka,et al.  Charged polypeptide vesicles with controllable diameter. , 2005, Journal of the American Chemical Society.

[64]  Ralph Müller,et al.  Repair of bone defects using synthetic mimetics of collagenous extracellular matrices , 2003, Nature Biotechnology.

[65]  R. Grubbs,et al.  Controlled living ring-opening-metathesis polymerization by a fast-initiating ruthenium catalyst. , 2003, Angewandte Chemie.