Prostate cancer and dietary carotenoids.

This population-based case-control study investigated associations between prostate cancer risk and dietary intake of the carotenoids beta-carotene and lycopene and their major plant food sources, including carrots, green leafy vegetables, and tomato-based foods. The study was carried out in Auckland, New Zealand, during 1996-1997 and recruited 317 prostate cancer cases and 480 controls. The authors found that dietary intake of beta-carotene and its main vegetable sources was largely unassociated with prostate cancer risk, whereas intake of lycopene and tomato-based foods was weakly associated with a reduced risk. These results suggest that in contrast to the findings regarding many types of cancers, vegetables rich in beta-carotene are not protective against prostate cancer. However, lycopene from tomato-based foods was found to be associated with a small reduction in risk.

[1]  W. Stahl,et al.  Lycopene is more bioavailable from tomato paste than from fresh tomatoes. , 1997, The American journal of clinical nutrition.

[2]  J. Mann,et al.  Randomised controlled trial of effect of fruit and vegetable consumption on plasma concentrations of lipids and antioxidants , 1997, BMJ.

[3]  J. Potter,et al.  Vegetables, fruit, and cancer prevention: a review. , 1996, Journal of the American Dietetic Association.

[4]  D. Bostwick,et al.  cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. , 1996, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[5]  G A Colditz,et al.  Intake of carotenoids and retinol in relation to risk of prostate cancer. , 1995, Journal of the National Cancer Institute.

[6]  J. Blumberg Considerations of the scientific substantiation for antioxidant vitamins and beta-carotene in disease prevention. , 1995, The American journal of clinical nutrition.

[7]  D. Karyadi,et al.  Lack of improvement in vitamin A status with increased consumption of dark-green leafy vegetables , 1995, The Lancet.

[8]  D Feskanich,et al.  Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire. , 1993, Journal of the American Dietetic Association.

[9]  J M Holden,et al.  Carotenoid content of fruits and vegetables: an evaluation of analytic data. , 1993, Journal of the American Dietetic Association.

[10]  G. Block,et al.  Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. , 1992, Nutrition and cancer.

[11]  F. Davis,et al.  Dietary and serum carotenoids and cervical intraepithelial neoplasia , 2007, International journal of cancer.

[12]  L. Kolonel,et al.  Prostate cancer: a current perspective. , 1991, Epidemiologic reviews.

[13]  B. Polk,et al.  Serologic precursors of cancer. Retinol, carotenoids, and tocopherol and risk of prostate cancer. , 1990, Journal of the National Cancer Institute.

[14]  J. S. Morris,et al.  Selenium, Lycopene, α-Tocopherol, β-Carotene, Retinol, and Subsequent Bladder Cancer , 1989 .

[15]  P. Di Mascio,et al.  Lycopene as the most efficient biological carotenoid singlet oxygen quencher. , 1989, Archives of biochemistry and biophysics.

[16]  W. L. Beeson,et al.  Cohort study of diet, lifestyle, and prostate cancer in adventist men , 1989, Cancer.

[17]  J. S. Morris,et al.  Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. , 1989, Cancer research.

[18]  R. Johnston A revision of socio-economic indices for New Zealand , 1983 .